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• W4308985893 abstract "Abstract Background A crucial role for the immune system has been proposed in the establishment and progression of head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the cytokine and regulatory profiles of T cells in tumor draining lymph nodes (TDLNs) of patients with HNSCC. Results The frequencies of CD4 + TNF-α + and CD4 + TNF-α hi negatively were associated with poor prognostic factors such as LN involvement ( P = 0.015 and P = 0.019, respectively), stage of the disease ( P = 0.032 and P = 0.010, respectively) and tumor size ( P = 0.026 and P = 0.032, respectively). Frequencies of CD8 + IFN-γ + and CD8 + IFN-γ + TNF-α + T cells showed negative relationship with tumor grade ( P = 0.035 and P = 0.043, respectively). While, the frequencies of CD4 + IL-4 + , CD8 + IL-10 + , CD8 + IL-4 + T cells were higher in advanced stages of the disease ( P = 0.042, P = 0.041 and P = 0.030, respectively) and CD4 + IFN-γ + TNF-α − , CD8 + IL-4 + and CD8 + IFN-γ + TNF-α − T cells were higher in patients with larger tumor size ( P = 0.026 and P = 0.032, respectively). Negative associations were found between the frequencies of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 + CD127 low/− Treg cells and cancer stage ( P = 0.015 and P = 0.059). Conclusion This study shed more lights on the changes in immune profile of T cells in TDLNs of HNSCC. Larger tumor size and/or LN involvement were associated with lower frequencies of CD4 + TNF-α + , CD8 + IFN-γ + and CD8 + IFN-γ + TNF-α + but higher frequency of CD4 + IL-4 + T cells. Moreover, Foxp3 + Tregs correlated with good prognostic indicators." @default.
• W4308985893 created "2022-11-20" @default.
• W4308985893 creator A5010916793 @default.
• W4308985893 creator A5013236139 @default.
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• W4308985893 creator A5089421522 @default.
• W4308985893 date "2022-11-15" @default.
• W4308985893 modified "2023-10-09" @default.
• W4308985893 title "Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck" @default.
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• W4308985893 doi "https://doi.org/10.1186/s12865-022-00530-3" @default.
• W4308985893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36376825" @default.

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