Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308989667> ?p ?o ?g. }
- W4308989667 endingPage "105595" @default.
- W4308989667 startingPage "105595" @default.
- W4308989667 abstract "Serotonin-1A receptor (5HT1AR) is highly expressed in corticolimbic regions and its deficit is associated with anxiety and depression. A similar reduction in 5HT1AR heterozygous knockout (Het) mice results in anxiety-like and increased stress-reactivity phenotypes. Here we describe immunological abnormalities in Het females, characterized by an activated state of innate and adaptive immune cells. Het males showed only limited immune dysregulation. Similar immune abnormalities were present in the genetically WT female (F1) but not male offspring of Het mothers, indicating sex-specific immune system abnormalities that are dependent on the mother's 5HT1AR deficit, known as maternal genetic effect or genetic nurture. Expression profiling of the maternal-fetal interface revealed reduced immune cell invasion to decidua and accelerated trophoblast migration. These data suggest that 5HT1AR deficit, by altering the maternal immune system and midgestational in utero environment, leads to sex-biased outcomes, predominantly immune dysregulation in the female and anxiety-like behavior in the male offspring." @default.
- W4308989667 created "2022-11-20" @default.
- W4308989667 creator A5001562111 @default.
- W4308989667 creator A5010634390 @default.
- W4308989667 creator A5042818928 @default.
- W4308989667 creator A5066264942 @default.
- W4308989667 creator A5072633613 @default.
- W4308989667 creator A5076697048 @default.
- W4308989667 creator A5081727838 @default.
- W4308989667 creator A5083357644 @default.
- W4308989667 creator A5083585022 @default.
- W4308989667 creator A5085378815 @default.
- W4308989667 date "2022-12-01" @default.
- W4308989667 modified "2023-09-26" @default.
- W4308989667 title "Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture" @default.
- W4308989667 cites W1496381585 @default.
- W4308989667 cites W1762430717 @default.
- W4308989667 cites W1987299915 @default.
- W4308989667 cites W1989259989 @default.
- W4308989667 cites W1994871447 @default.
- W4308989667 cites W1996019229 @default.
- W4308989667 cites W2002329350 @default.
- W4308989667 cites W2005133512 @default.
- W4308989667 cites W2008743836 @default.
- W4308989667 cites W2015076008 @default.
- W4308989667 cites W2015920061 @default.
- W4308989667 cites W2017097604 @default.
- W4308989667 cites W2022126078 @default.
- W4308989667 cites W2022654189 @default.
- W4308989667 cites W2022816995 @default.
- W4308989667 cites W2023101722 @default.
- W4308989667 cites W2024379900 @default.
- W4308989667 cites W2026736418 @default.
- W4308989667 cites W2032610103 @default.
- W4308989667 cites W2041257968 @default.
- W4308989667 cites W2050087878 @default.
- W4308989667 cites W2054219549 @default.
- W4308989667 cites W2057542824 @default.
- W4308989667 cites W2067006752 @default.
- W4308989667 cites W2070290419 @default.
- W4308989667 cites W2073255422 @default.
- W4308989667 cites W2075012323 @default.
- W4308989667 cites W2077121957 @default.
- W4308989667 cites W2078602533 @default.
- W4308989667 cites W2079063838 @default.
- W4308989667 cites W2081458788 @default.
- W4308989667 cites W2084035042 @default.
- W4308989667 cites W2086527370 @default.
- W4308989667 cites W2096822505 @default.
- W4308989667 cites W2100027531 @default.
- W4308989667 cites W2101822059 @default.
- W4308989667 cites W2101957891 @default.
- W4308989667 cites W2106885532 @default.
- W4308989667 cites W2112818206 @default.
- W4308989667 cites W2115182798 @default.
- W4308989667 cites W2122945456 @default.
- W4308989667 cites W2130463007 @default.
- W4308989667 cites W2131280315 @default.
- W4308989667 cites W2135514207 @default.
- W4308989667 cites W2143058377 @default.
- W4308989667 cites W2150090814 @default.
- W4308989667 cites W2152625378 @default.
- W4308989667 cites W2158271326 @default.
- W4308989667 cites W2159459394 @default.
- W4308989667 cites W2169466773 @default.
- W4308989667 cites W2292232356 @default.
- W4308989667 cites W2387625987 @default.
- W4308989667 cites W2503141921 @default.
- W4308989667 cites W2572551054 @default.
- W4308989667 cites W2592009433 @default.
- W4308989667 cites W2615409887 @default.
- W4308989667 cites W2735720719 @default.
- W4308989667 cites W2741178304 @default.
- W4308989667 cites W2766326990 @default.
- W4308989667 cites W2770085798 @default.
- W4308989667 cites W2788263670 @default.
- W4308989667 cites W2794765397 @default.
- W4308989667 cites W2799635660 @default.
- W4308989667 cites W2809244390 @default.
- W4308989667 cites W2894011049 @default.
- W4308989667 cites W2900144939 @default.
- W4308989667 cites W2941564859 @default.
- W4308989667 cites W3044190151 @default.
- W4308989667 cites W3094902985 @default.
- W4308989667 cites W3160146661 @default.
- W4308989667 cites W3162485228 @default.
- W4308989667 cites W3193171813 @default.
- W4308989667 cites W341404584 @default.
- W4308989667 cites W4210666981 @default.
- W4308989667 doi "https://doi.org/10.1016/j.isci.2022.105595" @default.
- W4308989667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36458257" @default.
- W4308989667 hasPublicationYear "2022" @default.
- W4308989667 type Work @default.
- W4308989667 citedByCount "1" @default.
- W4308989667 countsByYear W43089896672023 @default.
- W4308989667 crossrefType "journal-article" @default.
- W4308989667 hasAuthorship W4308989667A5001562111 @default.
- W4308989667 hasAuthorship W4308989667A5010634390 @default.