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• W4308991645 abstract "C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display unexpected discordant effects between the shared traits which are translated into discordant associations with clinical outcomes in subsequent phenome-wide association studies. Our findings provide insights into shared mechanisms underlying inflammation and lipid metabolism, representing potential preventive and therapeutic targets." @default.
• W4308991645 created "2022-11-20" @default.
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• W4308991645 date "2022-11-14" @default.
• W4308991645 modified "2023-10-16" @default.
• W4308991645 title "Pleiotropic genetic architecture and novel loci for C-reactive protein levels" @default.
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• W4308991645 doi "https://doi.org/10.1038/s41467-022-34688-6" @default.
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