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- W4308991792 abstract "Gentamicin C1a and the minor isomer C2b have been reported to have favorable properties in terms of antibacterial activity and toxicity compared to the commercial mixture from which they have previously been isolated by preparative high-performance liquid chromatography. We report straightforward syntheses of both compounds from readily available sisomicin by selective oxidation of the side chain in ring I, hydrogenation of the double bond in ring I to give the 5′-epi series, inversion of configuration at position 5′ under thermodynamic conditions, and installation of the 6′-amino group by reductive amination." @default.
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- W4308991792 date "2022-11-14" @default.
- W4308991792 modified "2023-09-27" @default.
- W4308991792 title "Synthesis of Gentamicin Minor Components: Gentamicin C1a and Gentamicin C2b" @default.
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- W4308991792 doi "https://doi.org/10.1021/acs.orglett.2c03616" @default.
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