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• W4308991978 abstract "Abstract Background Non-invasive brain stimulation methods for modulating brain activity via transcranial technologies like transcranial direct current stimulation (tDCS) are increasingly prevalent to investigate the relationship between modulated brain regions and stimulation outcomes. However, the inter-individual variability of tDCS has made it challenging to detect intervention effects at the group level. Collecting multiple modalities of magnetic resonance imaging data (i.e., structural and functional MRI) helps to investigate how dose-response ultimately shapes brain function in response to tDCS. Method We collected data in a randomized, triple-blind, sham-controlled trial with two parallel arms. Sixty participants with MUD were randomly assigned to sham or active tDCS (n=30 per group, 2 mA, 20 minutes, anode/cathode over F4/Fp1). Structural and functional MRI (including high-resolution T1 and T2-weighted MRI, resting-state fMRI, and methamphetamine cue-reactivity task with meth versus neutral cues) were collected immediately before and after tDCS. T1 and T2-weighted MRI data were used to generate head models for each individual to simulate electric fields. Associations between electric fields (dose) and changes in brain function (response) were investigated at four different levels: (1) voxel level, (2) regional level (atlas-based parcellation), (3) cluster level (active clusters in the contrast of interest), and (4) network level (both task-based and resting-state networks). Result At the (1) voxel-level, (2) regional level, and (3) cluster level, our results showed no significant correlation between changes in the functional activity and electric fields. However, (4) at the network level, a significant negative correlation was found between the electric field and ReHo in the default mode network (r=-0.46 (medium effect size), p corrected=0.018). For the network-level analysis of task-based fMRI data, frontoparietal connectivity showed a positive significant correlation with the electric field in the frontal stimulation site (r=0.41 (medium effect size), p corrected=0.03). Conclusion The proposed pipeline provides a methodological framework to analyze tDCS effects in terms of dose-response relationships at four different levels to directly link the electric field (dose) variability to the variability of the neural response to tDCS. The results suggest that network-based analysis might be a better approach to provide novel insights into the dependency of the neuromodulatory effects of tDCS on the brain’s regional current dose in each individual. Dose-response integration can be informative for dose optimization/customization or predictive/treatment-response biomarker extraction in future brain stimulation studies." @default.
• W4308991978 created "2022-11-20" @default.
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• W4308991978 date "2022-11-14" @default.
• W4308991978 modified "2023-10-16" @default.
• W4308991978 title "Dose-Response in Modulating Brain Function with Transcranial Direct Current Stimulation: From Local to Network Levels" @default.
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• W4308991978 doi "https://doi.org/10.1101/2022.11.08.22282088" @default.
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