Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308992051> ?p ?o ?g. }
- W4308992051 abstract "Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis remain unclear. We evaluated a patient with progressive, refractory Corynespora cassiicola phaeohyphomycosis and found that he carried biallelic deleterious mutations in CLEC7A encoding the CARD9-coupled, β-glucan-binding receptor, Dectin-1. The patient's PBMCs failed to produce TNF-α and IL-1β in response to β-glucan and/or C. cassiicola. To confirm the cellular and molecular requirements for immunity against C. cassiicola, we developed a mouse model of this infection. Mouse macrophages required Dectin-1 and CARD9 for IL-1β and TNF-α production, which enhanced fungal killing in an interdependent manner. Deficiency of either Dectin-1 or CARD9 was associated with more severe fungal disease, recapitulating the human observation. Because these data implicated impaired Dectin-1 responses in susceptibility to phaeohyphomycosis, we evaluated 17 additional unrelated patients with severe forms of the infection. We found that 12 out of 17 carried deleterious CLEC7A mutations associated with an altered Dectin-1 extracellular C-terminal domain and impaired Dectin-1-dependent cytokine production. Thus, we show that Dectin-1 and CARD9 promote protective TNF-α- and IL-1β-mediated macrophage defense against C. cassiicola. More broadly, we demonstrate that human Dectin-1 deficiency may contribute to susceptibility to severe phaeohyphomycosis by certain dematiaceous fungi." @default.
- W4308992051 created "2022-11-20" @default.
- W4308992051 creator A5000756517 @default.
- W4308992051 creator A5001322752 @default.
- W4308992051 creator A5002368482 @default.
- W4308992051 creator A5002541699 @default.
- W4308992051 creator A5004410792 @default.
- W4308992051 creator A5005758779 @default.
- W4308992051 creator A5011787037 @default.
- W4308992051 creator A5015556123 @default.
- W4308992051 creator A5016048962 @default.
- W4308992051 creator A5016895895 @default.
- W4308992051 creator A5017008767 @default.
- W4308992051 creator A5017578103 @default.
- W4308992051 creator A5018617653 @default.
- W4308992051 creator A5018766597 @default.
- W4308992051 creator A5018910683 @default.
- W4308992051 creator A5022540272 @default.
- W4308992051 creator A5023237095 @default.
- W4308992051 creator A5023659191 @default.
- W4308992051 creator A5025290510 @default.
- W4308992051 creator A5026908064 @default.
- W4308992051 creator A5027587575 @default.
- W4308992051 creator A5028472018 @default.
- W4308992051 creator A5031546400 @default.
- W4308992051 creator A5036568474 @default.
- W4308992051 creator A5037133462 @default.
- W4308992051 creator A5037387913 @default.
- W4308992051 creator A5038614518 @default.
- W4308992051 creator A5039813701 @default.
- W4308992051 creator A5042790565 @default.
- W4308992051 creator A5043103500 @default.
- W4308992051 creator A5044250397 @default.
- W4308992051 creator A5045546326 @default.
- W4308992051 creator A5046154701 @default.
- W4308992051 creator A5047846938 @default.
- W4308992051 creator A5048480083 @default.
- W4308992051 creator A5059029427 @default.
- W4308992051 creator A5063867007 @default.
- W4308992051 creator A5064407806 @default.
- W4308992051 creator A5064575184 @default.
- W4308992051 creator A5065888325 @default.
- W4308992051 creator A5066572643 @default.
- W4308992051 creator A5067419317 @default.
- W4308992051 creator A5073973521 @default.
- W4308992051 creator A5074919264 @default.
- W4308992051 creator A5075884909 @default.
- W4308992051 creator A5075982168 @default.
- W4308992051 creator A5077081877 @default.
- W4308992051 creator A5079058557 @default.
- W4308992051 creator A5079932633 @default.
- W4308992051 creator A5079960913 @default.
- W4308992051 creator A5081638997 @default.
- W4308992051 creator A5082240161 @default.
- W4308992051 creator A5082458518 @default.
- W4308992051 creator A5082720864 @default.
- W4308992051 creator A5083356969 @default.
- W4308992051 creator A5084060683 @default.
- W4308992051 creator A5085021937 @default.
- W4308992051 creator A5089792719 @default.
- W4308992051 creator A5089970205 @default.
- W4308992051 date "2022-11-15" @default.
- W4308992051 modified "2023-10-06" @default.
- W4308992051 title "Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis" @default.
- W4308992051 cites W1846119031 @default.
- W4308992051 cites W1967286461 @default.
- W4308992051 cites W1976672229 @default.
- W4308992051 cites W1997994303 @default.
- W4308992051 cites W1998903713 @default.
- W4308992051 cites W2009998721 @default.
- W4308992051 cites W2034453891 @default.
- W4308992051 cites W2038753879 @default.
- W4308992051 cites W2038850843 @default.
- W4308992051 cites W2040071356 @default.
- W4308992051 cites W2047001651 @default.
- W4308992051 cites W2065666266 @default.
- W4308992051 cites W2069166163 @default.
- W4308992051 cites W2071504008 @default.
- W4308992051 cites W2073900277 @default.
- W4308992051 cites W2092807701 @default.
- W4308992051 cites W2099053491 @default.
- W4308992051 cites W2099136629 @default.
- W4308992051 cites W2101233099 @default.
- W4308992051 cites W2101524137 @default.
- W4308992051 cites W2102426516 @default.
- W4308992051 cites W2108234281 @default.
- W4308992051 cites W2112698713 @default.
- W4308992051 cites W2112731526 @default.
- W4308992051 cites W2116481009 @default.
- W4308992051 cites W2119472512 @default.
- W4308992051 cites W2121687659 @default.
- W4308992051 cites W2124985265 @default.
- W4308992051 cites W2129113026 @default.
- W4308992051 cites W2150753599 @default.
- W4308992051 cites W2151554120 @default.
- W4308992051 cites W2155944224 @default.
- W4308992051 cites W2161446243 @default.
- W4308992051 cites W2163515200 @default.
- W4308992051 cites W2164500783 @default.
- W4308992051 cites W2165773179 @default.