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- W4308992953 abstract "Intra-tumoral immune cells promote the stemness of cancer stem cells (CSCs) in the tumor microenvironment (TME). CSCs promote tumor progression, relapse, and resistance to immunotherapy. Cancer stemness induces the expression of neoantigens and neo-properties in CSCs, creating an opportunity for targeted immunotherapies. Isolation of stem-like T cells or retaining stemness in T clonotypes strategies produces exhaustion-resistance T cells with superior re-expansion capacity and long-lasting responses after adoptive cell therapies. Stem cells-derived NK cells may be the next generation of NK cell products for immunotherapy. Here, we have reviewed mechanisms by which stemness factors modulated the immunoediting of the TME and summarized the potentials of CSCs in the development of immunotherapy regimens, including CAR-T cells, CAR-NK cells, cancer vaccines, and monoclonal antibodies. We have discussed the natural or genetically engineered stem-like T cells and stem cell-derived NK cells with increased cytotoxicity to tumor cells. Finally, we have provided a perspective on approaches that may improve the therapeutic efficacy of these novel adoptive cell-based products in targeting immunosuppressive TME." @default.
- W4308992953 created "2022-11-20" @default.
- W4308992953 creator A5013527852 @default.
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- W4308992953 creator A5040715170 @default.
- W4308992953 creator A5057765778 @default.
- W4308992953 creator A5068393808 @default.
- W4308992953 date "2023-02-01" @default.
- W4308992953 modified "2023-09-26" @default.
- W4308992953 title "Engaging stemness improves cancer immunotherapy" @default.
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