Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308993382> ?p ?o ?g. }
- W4308993382 endingPage "e0277457" @default.
- W4308993382 startingPage "e0277457" @default.
- W4308993382 abstract "Background Type-II diabetes mellitus (T2DM) is a major risk factor for cognitive impairment. Protecting the brain environment against inflammation, and neurodegeneration, as well as preservation of the BBB veracity through modulating the crosstalk between insulin/AKT/GSK-3β and Wnt/β-catenin signaling, might introduce novel therapeutic targets. Purpose This study aimed at exploring the possible neuroprotective potential of vitamin D3 (VitD) and/or rosuvastatin (RSV) in T2DM-induced cognitive deficits. Methods T2DM was induced by a high-fat sucrose diet and a single streptozotocin (STZ) dose. Diabetic rats were allocated into a diabetic control and three groups treated with RSV (15 mg/kg/day, PO), VitD (500 IU/kg/day, PO), or their combination. Results Administration of VitD and/or RSV mitigated T2DM-induced metabolic abnormalities and restored the balance between the anti-inflammatory, IL 27 and the proinflammatory, IL 23 levels in the hippocampus. In addition, they markedly activated both the canonical and noncanonical Wnt/β-catenin cassettes with stimulation of their downstream molecular targets. VitD and/or RSV upregulated insulin and α7 nicotinic acetylcholine (α7nACh) receptors gene expression, as well as blood-brain barrier integrity markers including Annexin A1, claudin 3, and VE-cadherin. Also, they obliterated hippocampal ApoE-4 content, Tau hyperphosphorylation, and Aβ deposition. These biochemical changes were reflected as improved behavioral performance in Morris water maze and novel object recognition tests and restored hippocampal histological profile. Conclusion The current findings have accentuated the neuroprotective potential of VitD and RSV and provide new incentives to expand their use in T2DM-induced cognitive and memory decline. This study also suggests a superior benefit of combining both treatments over either drug alone." @default.
- W4308993382 created "2022-11-20" @default.
- W4308993382 creator A5009375333 @default.
- W4308993382 creator A5029873978 @default.
- W4308993382 creator A5032651673 @default.
- W4308993382 creator A5063803369 @default.
- W4308993382 date "2022-11-14" @default.
- W4308993382 modified "2023-09-26" @default.
- W4308993382 title "Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling" @default.
- W4308993382 cites W1533309927 @default.
- W4308993382 cites W1742641335 @default.
- W4308993382 cites W1819107323 @default.
- W4308993382 cites W1969344434 @default.
- W4308993382 cites W1980947593 @default.
- W4308993382 cites W198103589 @default.
- W4308993382 cites W1992431456 @default.
- W4308993382 cites W1995491925 @default.
- W4308993382 cites W2009874139 @default.
- W4308993382 cites W2011109341 @default.
- W4308993382 cites W2013952491 @default.
- W4308993382 cites W2017872978 @default.
- W4308993382 cites W2021222203 @default.
- W4308993382 cites W2029820081 @default.
- W4308993382 cites W2030190613 @default.
- W4308993382 cites W2031746740 @default.
- W4308993382 cites W2034932339 @default.
- W4308993382 cites W2036706062 @default.
- W4308993382 cites W2037380656 @default.
- W4308993382 cites W2049871798 @default.
- W4308993382 cites W2049971830 @default.
- W4308993382 cites W2057042201 @default.
- W4308993382 cites W2060521721 @default.
- W4308993382 cites W2065262114 @default.
- W4308993382 cites W2072252074 @default.
- W4308993382 cites W2083103946 @default.
- W4308993382 cites W2083884524 @default.
- W4308993382 cites W2084761782 @default.
- W4308993382 cites W2084884103 @default.
- W4308993382 cites W2091691811 @default.
- W4308993382 cites W2092615804 @default.
- W4308993382 cites W2094063510 @default.
- W4308993382 cites W2101129883 @default.
- W4308993382 cites W2104698018 @default.
- W4308993382 cites W2111598959 @default.
- W4308993382 cites W2122522567 @default.
- W4308993382 cites W2123416594 @default.
- W4308993382 cites W2135631433 @default.
- W4308993382 cites W2138819627 @default.
- W4308993382 cites W2147403614 @default.
- W4308993382 cites W2148922393 @default.
- W4308993382 cites W2150135472 @default.
- W4308993382 cites W2156224448 @default.
- W4308993382 cites W2164413420 @default.
- W4308993382 cites W2170864435 @default.
- W4308993382 cites W2244276231 @default.
- W4308993382 cites W2266173332 @default.
- W4308993382 cites W2298983808 @default.
- W4308993382 cites W2307324788 @default.
- W4308993382 cites W2404128804 @default.
- W4308993382 cites W2540109840 @default.
- W4308993382 cites W2562262699 @default.
- W4308993382 cites W2608076792 @default.
- W4308993382 cites W2732836268 @default.
- W4308993382 cites W2737994022 @default.
- W4308993382 cites W2770560974 @default.
- W4308993382 cites W2771830691 @default.
- W4308993382 cites W2773526606 @default.
- W4308993382 cites W2788794362 @default.
- W4308993382 cites W2789433391 @default.
- W4308993382 cites W2790346667 @default.
- W4308993382 cites W2792415059 @default.
- W4308993382 cites W2793678678 @default.
- W4308993382 cites W2804519474 @default.
- W4308993382 cites W2804775036 @default.
- W4308993382 cites W2811478046 @default.
- W4308993382 cites W2900218132 @default.
- W4308993382 cites W2900869166 @default.
- W4308993382 cites W2901104423 @default.
- W4308993382 cites W2905566223 @default.
- W4308993382 cites W2907270550 @default.
- W4308993382 cites W2945374467 @default.
- W4308993382 cites W2948305628 @default.
- W4308993382 cites W2953982330 @default.
- W4308993382 cites W2964682226 @default.
- W4308993382 cites W2977810401 @default.
- W4308993382 cites W2980342560 @default.
- W4308993382 cites W2991246038 @default.
- W4308993382 cites W2992128791 @default.
- W4308993382 cites W2992486783 @default.
- W4308993382 cites W2996772472 @default.
- W4308993382 cites W3004085449 @default.
- W4308993382 cites W3014463892 @default.
- W4308993382 cites W3017536446 @default.
- W4308993382 cites W3039540412 @default.
- W4308993382 cites W3045828365 @default.
- W4308993382 cites W3047509830 @default.
- W4308993382 cites W3048767440 @default.
- W4308993382 cites W3133566955 @default.