FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308993679> ?p ?o ?g. }

• W4308993679 endingPage "118" @default.
• W4308993679 startingPage "107" @default.
• W4308993679 abstract "Objectives To perform a systematic literature review (SLR) concerning the safety of synthetic(s) and biological (b) disease-modifying antirheumatic drugs (DMARDs) to inform the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis (RA). Methods SLR of observational studies comparing safety outcomes of any DMARD with another intervention in RA. A comparator group was required for inclusion. For treatments yet without, or limited, registry data, randomised controlled trials (RCTs) were used. Results Fifty-nine observational studies addressed the safety of DMARDs. Two studies (unclear risk of bias (RoB)) showed an increased risk of serious infections with bDMARDs compared with conventional synthetic (cs)DMARDs. Herpes zoster infections occurred more with JAKi than csDMARDs (adjusted HR (aHR): 3.66) and bDMARDs (aHR: 1.9–2.3) (four studies, two low RoB). The risk of malignancies was similar across bDMARDs (five studies) and with tofacitinib compared with bDMARDs (one study, low RoB). The risk of major adverse cardiovascular events (MACE) was similar with bDMARDs and tofacitinib (two studies, one low RoB). Thirty studies reported safety from RCTs, with one, designed to evaluate safety, showing that malignancies (HR (95% CI): 1.48 (1.04 to 2.09)) and MACE (HR (95% CI): 1.33 (0.91 to 1.94)) occurred numerically more frequently with tofacitinib (5 mg and 10 mg doses combined) than with TNFi in patients with cardiovascular risk factors. In this study, the risk of venous thromboembolism (VTE) was higher with tofacitinib 10 mg than with TNFi. Conclusion The safety profile of bDMARDs was further demonstrated. Whether the difference in incidence of malignancies, MACE and VTE between tofacitinib and TNFi applies to other JAKi needs further evaluation." @default.
• W4308993679 created "2022-11-20" @default.
• W4308993679 creator A5000282057 @default.
• W4308993679 creator A5000926745 @default.
• W4308993679 creator A5006070255 @default.
• W4308993679 creator A5020718006 @default.
• W4308993679 creator A5023213876 @default.
• W4308993679 creator A5036981821 @default.
• W4308993679 creator A5043612857 @default.
• W4308993679 creator A5053288231 @default.
• W4308993679 creator A5061411814 @default.
• W4308993679 creator A5076151386 @default.
• W4308993679 creator A5077554218 @default.
• W4308993679 creator A5080267247 @default.
• W4308993679 creator A5083314956 @default.
• W4308993679 creator A5085359664 @default.
• W4308993679 creator A5089158758 @default.
• W4308993679 creator A5090277186 @default.
• W4308993679 creator A5090753435 @default.
• W4308993679 date "2022-11-14" @default.
• W4308993679 modified "2023-10-17" @default.
• W4308993679 title "Safety of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis" @default.
• W4308993679 cites W1985018583 @default.
• W4308993679 cites W2062105256 @default.
• W4308993679 cites W2098923148 @default.
• W4308993679 cites W2117335168 @default.
• W4308993679 cites W2117847674 @default.
• W4308993679 cites W2122814783 @default.
• W4308993679 cites W2133701923 @default.
• W4308993679 cites W2163184895 @default.
• W4308993679 cites W2167939282 @default.
• W4308993679 cites W2169773326 @default.
• W4308993679 cites W2735120995 @default.
• W4308993679 cites W2770644848 @default.
• W4308993679 cites W2891623007 @default.
• W4308993679 cites W2895888657 @default.
• W4308993679 cites W2903783989 @default.
• W4308993679 cites W2906253210 @default.
• W4308993679 cites W2912182619 @default.
• W4308993679 cites W2913606374 @default.
• W4308993679 cites W2914900088 @default.
• W4308993679 cites W2922089356 @default.
• W4308993679 cites W2937720102 @default.
• W4308993679 cites W2941325135 @default.
• W4308993679 cites W2942777319 @default.
• W4308993679 cites W2942970564 @default.
• W4308993679 cites W2943342119 @default.
• W4308993679 cites W2946233321 @default.
• W4308993679 cites W2952905145 @default.
• W4308993679 cites W2953784119 @default.
• W4308993679 cites W2953786099 @default.
• W4308993679 cites W2961111920 @default.
• W4308993679 cites W2962938985 @default.
• W4308993679 cites W2965035961 @default.
• W4308993679 cites W2965540452 @default.
• W4308993679 cites W2966003866 @default.
• W4308993679 cites W2966045035 @default.
• W4308993679 cites W2968072409 @default.
• W4308993679 cites W2971086071 @default.
• W4308993679 cites W2974844397 @default.
• W4308993679 cites W2979726065 @default.
• W4308993679 cites W2980981440 @default.
• W4308993679 cites W2988297889 @default.
• W4308993679 cites W2991518720 @default.
• W4308993679 cites W2997321472 @default.
• W4308993679 cites W2999988802 @default.
• W4308993679 cites W3000382576 @default.
• W4308993679 cites W3005067674 @default.
• W4308993679 cites W3005232241 @default.
• W4308993679 cites W3011249803 @default.
• W4308993679 cites W3011894734 @default.
• W4308993679 cites W3016252363 @default.
• W4308993679 cites W3019692647 @default.
• W4308993679 cites W3021665373 @default.
• W4308993679 cites W3034380047 @default.
• W4308993679 cites W3041856700 @default.
• W4308993679 cites W3042809965 @default.
• W4308993679 cites W3043803789 @default.
• W4308993679 cites W3049141538 @default.
• W4308993679 cites W3067575571 @default.
• W4308993679 cites W3092992115 @default.
• W4308993679 cites W3093431278 @default.
• W4308993679 cites W3096804185 @default.
• W4308993679 cites W3096902844 @default.
• W4308993679 cites W3099218816 @default.
• W4308993679 cites W3118431063 @default.
• W4308993679 cites W3118646829 @default.
• W4308993679 cites W3121233650 @default.
• W4308993679 cites W3122335821 @default.
• W4308993679 cites W3124339251 @default.
• W4308993679 cites W3126428172 @default.
• W4308993679 cites W3126579487 @default.
• W4308993679 cites W3128990629 @default.
• W4308993679 cites W3133674083 @default.
• W4308993679 cites W3139515949 @default.
• W4308993679 cites W3152812963 @default.
• W4308993679 cites W3152890019 @default.
• W4308993679 cites W3153043519 @default.

• next