FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308995729> ?p ?o ?g. }

• W4308995729 abstract "Abstract The activation of M1-type macrophages are dominant cells secreting proinflammatory present within the inflamed synovium in the progression of osteoarthritis (OA). Increased oxidative stress, such as redundant ROS and hydrogen peroxide (H 2 O 2 ), are important factors in driving macrophages to polarize into M1 type. In this study, metal-polyphenol nanoformulations (Cu-Epigallocatechin-3-gallate (Cu-EGCG) nanosheets) were synthesized through the coordination interaction between EGCG and copper ions, which possess the antioxidant effect of EGCG and anti-inflammatory of Cu 2+ . Results showed that Cu-EGCG nanosheets are biocompatible and the Cu 2+ could be sustained released from the nanoparticles. Exhibiting multienzyme-like antioxidative activity, Cu-EGCG nanosheets could effectively scavenge the excessive intracellular ROS, leading to significantly decreased expression of the pro-inflammatory cytokines, which could reduce the expression of M1-type macrophages and exhibit excellent promotion on shifting macrophages to M2 phenotypes. Moreover, the secreted factor from the cell supernatant of Cu-EGCG treated macrophages exhibited anti-inflammatory potential in chondrocytes of inflamed synovial joints. This study suggests a novel strategy for OA therapy by using metal-polyphenol nanoformulations targeting macrophages." @default.
• W4308995729 created "2022-11-20" @default.
• W4308995729 creator A5000756717 @default.
• W4308995729 creator A5005788616 @default.
• W4308995729 creator A5006483197 @default.
• W4308995729 creator A5006592775 @default.
• W4308995729 creator A5014470814 @default.
• W4308995729 creator A5024257252 @default.
• W4308995729 creator A5070285748 @default.
• W4308995729 date "2022-11-14" @default.
• W4308995729 modified "2023-09-27" @default.
• W4308995729 title "Epigallocatechin-3-gallate (EGCG) based Metal-polyphenol nanoformulations alleviates chondrocytes inflammation by modulating synovial macrophages polarization" @default.
• W4308995729 cites W1966521314 @default.
• W4308995729 cites W1989276894 @default.
• W4308995729 cites W1989834585 @default.
• W4308995729 cites W2011928284 @default.
• W4308995729 cites W2031070839 @default.
• W4308995729 cites W2048134562 @default.
• W4308995729 cites W2062697678 @default.
• W4308995729 cites W2086771075 @default.
• W4308995729 cites W2090113481 @default.
• W4308995729 cites W2099489843 @default.
• W4308995729 cites W2104086585 @default.
• W4308995729 cites W2108201978 @default.
• W4308995729 cites W2142693119 @default.
• W4308995729 cites W2147593455 @default.
• W4308995729 cites W2155995107 @default.
• W4308995729 cites W2157929110 @default.
• W4308995729 cites W2159957679 @default.
• W4308995729 cites W2314405504 @default.
• W4308995729 cites W2398664613 @default.
• W4308995729 cites W2510495333 @default.
• W4308995729 cites W2550090579 @default.
• W4308995729 cites W2558559567 @default.
• W4308995729 cites W2786119245 @default.
• W4308995729 cites W2862130988 @default.
• W4308995729 cites W2887840888 @default.
• W4308995729 cites W2889101189 @default.
• W4308995729 cites W2903169176 @default.
• W4308995729 cites W2903246763 @default.
• W4308995729 cites W2947653511 @default.
• W4308995729 cites W2955927408 @default.
• W4308995729 cites W2971095732 @default.
• W4308995729 cites W2974242780 @default.
• W4308995729 cites W2996774074 @default.
• W4308995729 cites W3000734109 @default.
• W4308995729 cites W3002710359 @default.
• W4308995729 cites W3005714245 @default.
• W4308995729 cites W3033966010 @default.
• W4308995729 cites W3049488515 @default.
• W4308995729 cites W3093281616 @default.
• W4308995729 cites W3127107918 @default.
• W4308995729 cites W3130488554 @default.
• W4308995729 cites W3131190077 @default.
• W4308995729 cites W3168283422 @default.
• W4308995729 cites W3206332654 @default.
• W4308995729 doi "https://doi.org/10.21203/rs.3.rs-2247296/v1" @default.
• W4308995729 hasPublicationYear "2022" @default.
• W4308995729 type Work @default.
• W4308995729 citedByCount "0" @default.
• W4308995729 crossrefType "posted-content" @default.
• W4308995729 hasAuthorship W4308995729A5000756717 @default.
• W4308995729 hasAuthorship W4308995729A5005788616 @default.
• W4308995729 hasAuthorship W4308995729A5006483197 @default.
• W4308995729 hasAuthorship W4308995729A5006592775 @default.
• W4308995729 hasAuthorship W4308995729A5014470814 @default.
• W4308995729 hasAuthorship W4308995729A5024257252 @default.
• W4308995729 hasAuthorship W4308995729A5070285748 @default.
• W4308995729 hasBestOaLocation W43089957291 @default.
• W4308995729 hasConcept C13965031 @default.
• W4308995729 hasConcept C164027704 @default.
• W4308995729 hasConcept C185592680 @default.
• W4308995729 hasConcept C203014093 @default.
• W4308995729 hasConcept C2776914184 @default.
• W4308995729 hasConcept C2778004101 @default.
• W4308995729 hasConcept C2780295536 @default.
• W4308995729 hasConcept C502942594 @default.
• W4308995729 hasConcept C533411734 @default.
• W4308995729 hasConcept C55493867 @default.
• W4308995729 hasConcept C70899900 @default.
• W4308995729 hasConcept C71924100 @default.
• W4308995729 hasConcept C86803240 @default.
• W4308995729 hasConcept C95444343 @default.
• W4308995729 hasConceptScore W4308995729C13965031 @default.
• W4308995729 hasConceptScore W4308995729C164027704 @default.
• W4308995729 hasConceptScore W4308995729C185592680 @default.
• W4308995729 hasConceptScore W4308995729C203014093 @default.
• W4308995729 hasConceptScore W4308995729C2776914184 @default.
• W4308995729 hasConceptScore W4308995729C2778004101 @default.
• W4308995729 hasConceptScore W4308995729C2780295536 @default.
• W4308995729 hasConceptScore W4308995729C502942594 @default.
• W4308995729 hasConceptScore W4308995729C533411734 @default.
• W4308995729 hasConceptScore W4308995729C55493867 @default.
• W4308995729 hasConceptScore W4308995729C70899900 @default.
• W4308995729 hasConceptScore W4308995729C71924100 @default.
• W4308995729 hasConceptScore W4308995729C86803240 @default.
• W4308995729 hasConceptScore W4308995729C95444343 @default.
• W4308995729 hasLocation W43089957291 @default.
• W4308995729 hasOpenAccess W4308995729 @default.
• W4308995729 hasPrimaryLocation W43089957291 @default.

• next