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- W4308996985 abstract "Numerous studies have highlighted the role of miRNA in the deformation and necrosis of cells of ovarian tissue caused by heat stress (HS), which ultimately affects ovarian function. Although the role of small RNAs has been investigated in alterations in ovarian tissue functioning in response to HS, the expression profile of ovarian miRNA has been explored to a lesser extent. In this study, female rabbits were subject to HS treatment by using electrical heater. The current work demonstrated that HS could significantly change physiological performance of female rabbits including body weight, rectal temperature and relative ovary weight, and significantly reduce serum IL-2, IL-8, CAT , and GSH-Px concentrations by enzyme-linked immunosorbent assay (ELISA) technique. As a result, an increase in apoptosis in ovarian cells, as well as unhealthy follicles, were observed by Hematoxylin-eosin (HE) and TUNEL staining. Additionally, small RNA-seq revealed changes in the miRNA expression profile of rabbit ovaries under HS. Five hundred fourteen miRNAs were obtained including known miRNAs 442 and novel miRNAs 72. Among these miRNAs, 23 miRNAs were significantly expressed under HS. Eleven differentially expressed miRNAs (DE miRNAs) and 9 their predicted targets were confirmed by qPCR, which were expected miRNA–mRNA negative regulation pattern. Among the DE miRNAs and targets, miR-141-39 may target COQ6 , miR-449a-5p and miR-34c-5p may control RFC5 and RTN2 together, miR-449a-5p may target ACADVL , miR-34c-5p potentially targets Bcl-2 and miR-196b-5p potentially regulates CASK and HOXB6 . Thus, the current work suggested the negative effects of HS on the ovarian tissue of female rabbits, and in conclusion these changes could be caused by decreased serum IL-2, IL-8, CAT and GSH-Px levels, increased ovarian apoptosis, and changed the expression of miRNAs." @default.
- W4308996985 created "2022-11-20" @default.
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- W4308996985 date "2022-11-14" @default.
- W4308996985 modified "2023-10-14" @default.
- W4308996985 title "Negative effects of heat stress on ovarian tissue in female rabbit" @default.
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- W4308996985 doi "https://doi.org/10.3389/fvets.2022.1009182" @default.
- W4308996985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36452142" @default.
- W4308996985 hasPublicationYear "2022" @default.
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