Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308997133> ?p ?o ?g. }
- W4308997133 abstract "Peripheral T cells express a diverse repertoire of antigen-specific receptors, which together protect against the full range of pathogens. In this context, the total repertoire of memory T cells which are maintained by trophic signals, long after pathogen clearance, is critical. Since these trophic factors include cytokines and self-peptide-MHC, both of which are available from endogenous antigen-presenting cells (APC), we hypothesized that enhancing APC numbers in vivo can be a viable strategy to amplify the population of memory T cells. We evaluated this by acutely treating intact mice with FMS-like tyrosine kinase 3 ligand (Flt3l), which promotes expansion of APCs. Here we report that this treatment allowed for, an expansion of effector-memory CD4+ and CD8+ T cells as well as an increase in their expression of KLRG1 and CD25. In the lymph nodes and spleen, the expansion was limited to a specific CD8 (CD44-low but CD62L-) subset. Functionally, this subset is distinct from naïve T cells and could produce significant amounts of effector cytokines upon restimulation. Taken together, these data suggest that the administration of Flt3L can impact both APC turnover as well as a corresponding flux of specific subsets of CD8+ T cells in an intact peripheral immune compartment." @default.
- W4308997133 created "2022-11-20" @default.
- W4308997133 creator A5013947551 @default.
- W4308997133 creator A5024859859 @default.
- W4308997133 creator A5050647164 @default.
- W4308997133 creator A5068129275 @default.
- W4308997133 creator A5091297121 @default.
- W4308997133 date "2022-11-14" @default.
- W4308997133 modified "2023-09-27" @default.
- W4308997133 title "Acute effects of FLT3L treatment on T cells in intact mice" @default.
- W4308997133 cites W1499607673 @default.
- W4308997133 cites W1508676807 @default.
- W4308997133 cites W154795380 @default.
- W4308997133 cites W1594591001 @default.
- W4308997133 cites W1601504908 @default.
- W4308997133 cites W174304716 @default.
- W4308997133 cites W1862322995 @default.
- W4308997133 cites W1960462362 @default.
- W4308997133 cites W1972511495 @default.
- W4308997133 cites W1972626855 @default.
- W4308997133 cites W1972776798 @default.
- W4308997133 cites W1973639800 @default.
- W4308997133 cites W1976199086 @default.
- W4308997133 cites W1985294654 @default.
- W4308997133 cites W1993525971 @default.
- W4308997133 cites W2003336545 @default.
- W4308997133 cites W2008366157 @default.
- W4308997133 cites W2012497305 @default.
- W4308997133 cites W2014161666 @default.
- W4308997133 cites W2022477357 @default.
- W4308997133 cites W2023500151 @default.
- W4308997133 cites W2024410915 @default.
- W4308997133 cites W2031537098 @default.
- W4308997133 cites W2033505817 @default.
- W4308997133 cites W2035335588 @default.
- W4308997133 cites W2036343152 @default.
- W4308997133 cites W2040370363 @default.
- W4308997133 cites W2046830231 @default.
- W4308997133 cites W2052683719 @default.
- W4308997133 cites W2055548320 @default.
- W4308997133 cites W2057698592 @default.
- W4308997133 cites W2058158581 @default.
- W4308997133 cites W2076766124 @default.
- W4308997133 cites W2084524844 @default.
- W4308997133 cites W2087739817 @default.
- W4308997133 cites W2088597221 @default.
- W4308997133 cites W2097400502 @default.
- W4308997133 cites W2100626956 @default.
- W4308997133 cites W2106648243 @default.
- W4308997133 cites W2122830690 @default.
- W4308997133 cites W2134916334 @default.
- W4308997133 cites W2142084466 @default.
- W4308997133 cites W2151222524 @default.
- W4308997133 cites W2151551667 @default.
- W4308997133 cites W2156831625 @default.
- W4308997133 cites W2163955606 @default.
- W4308997133 cites W2168028214 @default.
- W4308997133 cites W2169539795 @default.
- W4308997133 cites W2341604280 @default.
- W4308997133 cites W2343060625 @default.
- W4308997133 cites W2520453304 @default.
- W4308997133 cites W2562506237 @default.
- W4308997133 cites W2619094261 @default.
- W4308997133 cites W2772668082 @default.
- W4308997133 cites W2789026035 @default.
- W4308997133 cites W2795250078 @default.
- W4308997133 cites W2890668496 @default.
- W4308997133 cites W2900562404 @default.
- W4308997133 cites W2901221545 @default.
- W4308997133 cites W2950578975 @default.
- W4308997133 cites W3025214800 @default.
- W4308997133 cites W3033757442 @default.
- W4308997133 cites W3133959227 @default.
- W4308997133 cites W3164248521 @default.
- W4308997133 cites W3164499496 @default.
- W4308997133 cites W78744612 @default.
- W4308997133 doi "https://doi.org/10.1038/s41598-022-24126-4" @default.
- W4308997133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36376544" @default.
- W4308997133 hasPublicationYear "2022" @default.
- W4308997133 type Work @default.
- W4308997133 citedByCount "0" @default.
- W4308997133 crossrefType "journal-article" @default.
- W4308997133 hasAuthorship W4308997133A5013947551 @default.
- W4308997133 hasAuthorship W4308997133A5024859859 @default.
- W4308997133 hasAuthorship W4308997133A5050647164 @default.
- W4308997133 hasAuthorship W4308997133A5068129275 @default.
- W4308997133 hasAuthorship W4308997133A5091297121 @default.
- W4308997133 hasBestOaLocation W43089971331 @default.
- W4308997133 hasConcept C120642132 @default.
- W4308997133 hasConcept C129374314 @default.
- W4308997133 hasConcept C148125776 @default.
- W4308997133 hasConcept C154317977 @default.
- W4308997133 hasConcept C167672396 @default.
- W4308997133 hasConcept C202751555 @default.
- W4308997133 hasConcept C203014093 @default.
- W4308997133 hasConcept C2776090121 @default.
- W4308997133 hasConcept C2908647359 @default.
- W4308997133 hasConcept C55493867 @default.
- W4308997133 hasConcept C67662055 @default.
- W4308997133 hasConcept C71924100 @default.