FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308997383> ?p ?o ?g. }

• W4308997383 endingPage "982" @default.
• W4308997383 startingPage "972" @default.
• W4308997383 abstract "Due to the high prevalence of allergies and asthma, awareness about allergens and therapeutic use of functional foods and nutraceuticals have gained immense attention. Spirulina powder is being used as health-boosting and antioxidant agent against several ailments owing to its unique nutritional profile. Considering its antioxidant role, the current study was focused on exploring therapeutic role of spirulina against stress biomarkers in asthmatic model. To assess the therapeutic efficacy of spirulina against allergic asthma-specific oxidative stress biomarkers, a model feed trial was conducted and rats were divided into four groups (n = 10). G0-I (negative control), G0-II (positive control), whereas GI (spirulina) and G2 (salbutamol) served as treatment groups. Salbutamol is a chemical compound which is used in several antiallergic medicines because it works as bronchodilator. G2 group was given salbutamol for comparison of results. For asthma induction, rats were given intraperitoneal injection of ovalbumin on 7th, 14th, and 21st day. Treatment groups were given spirulina powder (500 mg/kg body weight) and salbutamol (1 mg/kg), respectively, after the induction of asthma. All three asthmatic groups were also exposed to cigarette smoke daily along with respective treatment for 4 weeks. Asthma induction caused an increase in total cell count in bronchioalveolar fluid (BALF), while spirulina treatment reduced total cells in BALF by 33.50% and salbutamol by 41.7%. Level of interleukins (IL) like IL-4 decreased by 33.32% & 48.56% in G1 and G2. Similarly, IL-5 and IL-13 levels reduced by 40.9% & 49.9% and 18.62% & 38.02%, respectively, in G1 and G2. Serum levels of Immunoglobin-E (Ig-E) declined by 29.70% and 52.82%, while histamine levels were 26.23% & 45.58% less at the end of study in comparison to positive control. Moreover, histological analysis of lung tissue revealed that both spirulina and salbutamol effectively reduced ovalbumin and cigarette smoke-induced moderate to severe necrosis, architectural changes, and congestion. It was concluded that salbutamol showed better results however, spirulina also effectively reduced mild to moderate allergic symptoms in dose-dependent manner. Nutraceutical and functional foods are considered helpful in mitigating oxidative stress-mediated health problems. Spirulina has its unique nutritional profile including phycobiliproteins, phytochemicals, and antioxidant vitamins which make it useful against several ailments. Considering its antioxidant role, current study was focused on exploring therapeutic efficacy of spirulina against stress biomarkers in asthmatic model. Outcomes of present research also demonstrated beneficial effect of spirulina in modulating allergic symptoms. In this regard, ancient concept of medicine food homology can be implemented and spirulina can be incorporated in food for additional benefits. However, further research regarding safety aspects is needed for its use in clinical practice for humans." @default.
• W4308997383 created "2022-11-20" @default.
• W4308997383 creator A5001838793 @default.
• W4308997383 creator A5012903339 @default.
• W4308997383 creator A5044676357 @default.
• W4308997383 creator A5064833255 @default.
• W4308997383 date "2022-11-14" @default.
• W4308997383 modified "2023-09-30" @default.
• W4308997383 title "Therapeutic efficacy of spirulina against ovalbumin and cigarette smoke‐induced asthma‐specific stress biomarkers in Sprague–Dawley rats" @default.
• W4308997383 cites W1903740479 @default.
• W4308997383 cites W1991764806 @default.
• W4308997383 cites W1992101256 @default.
• W4308997383 cites W2001660903 @default.
• W4308997383 cites W2008207679 @default.
• W4308997383 cites W2021718899 @default.
• W4308997383 cites W2025489767 @default.
• W4308997383 cites W2038379636 @default.
• W4308997383 cites W2038837580 @default.
• W4308997383 cites W2040535455 @default.
• W4308997383 cites W2048139865 @default.
• W4308997383 cites W2074756741 @default.
• W4308997383 cites W2078973301 @default.
• W4308997383 cites W2084141237 @default.
• W4308997383 cites W2149778838 @default.
• W4308997383 cites W2184063809 @default.
• W4308997383 cites W2266256585 @default.
• W4308997383 cites W231941926 @default.
• W4308997383 cites W2415454315 @default.
• W4308997383 cites W2509592375 @default.
• W4308997383 cites W2548403041 @default.
• W4308997383 cites W2594033175 @default.
• W4308997383 cites W2604147277 @default.
• W4308997383 cites W2614172426 @default.
• W4308997383 cites W2779161023 @default.
• W4308997383 cites W2790257292 @default.
• W4308997383 cites W2793420729 @default.
• W4308997383 cites W2803216659 @default.
• W4308997383 cites W2803534177 @default.
• W4308997383 cites W2809788210 @default.
• W4308997383 cites W2888629654 @default.
• W4308997383 cites W2896667117 @default.
• W4308997383 cites W2917717428 @default.
• W4308997383 cites W2989614424 @default.
• W4308997383 cites W2996021383 @default.
• W4308997383 cites W2997933217 @default.
• W4308997383 cites W3003816710 @default.
• W4308997383 cites W3013888409 @default.
• W4308997383 cites W3035787046 @default.
• W4308997383 cites W3038721744 @default.
• W4308997383 cites W3093753665 @default.
• W4308997383 cites W3096202156 @default.
• W4308997383 cites W3109010169 @default.
• W4308997383 cites W3111084114 @default.
• W4308997383 cites W3116780284 @default.
• W4308997383 cites W3120744886 @default.
• W4308997383 cites W3120796552 @default.
• W4308997383 cites W3124332587 @default.
• W4308997383 cites W3132257148 @default.
• W4308997383 cites W3138955020 @default.
• W4308997383 cites W3140114979 @default.
• W4308997383 cites W3152671556 @default.
• W4308997383 cites W3153593728 @default.
• W4308997383 cites W3158467182 @default.
• W4308997383 cites W3173288318 @default.
• W4308997383 cites W4246070331 @default.
• W4308997383 doi "https://doi.org/10.1002/fsn3.3132" @default.
• W4308997383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36789047" @default.
• W4308997383 hasPublicationYear "2022" @default.
• W4308997383 type Work @default.
• W4308997383 citedByCount "0" @default.
• W4308997383 crossrefType "journal-article" @default.
• W4308997383 hasAuthorship W4308997383A5001838793 @default.
• W4308997383 hasAuthorship W4308997383A5012903339 @default.
• W4308997383 hasAuthorship W4308997383A5044676357 @default.
• W4308997383 hasAuthorship W4308997383A5064833255 @default.
• W4308997383 hasBestOaLocation W43089973831 @default.
• W4308997383 hasConcept C126322002 @default.
• W4308997383 hasConcept C178790620 @default.
• W4308997383 hasConcept C185592680 @default.
• W4308997383 hasConcept C203014093 @default.
• W4308997383 hasConcept C206139338 @default.
• W4308997383 hasConcept C207480886 @default.
• W4308997383 hasConcept C2776042228 @default.
• W4308997383 hasConcept C2776151105 @default.
• W4308997383 hasConcept C2776946954 @default.
• W4308997383 hasConcept C2777394947 @default.
• W4308997383 hasConcept C2778004101 @default.
• W4308997383 hasConcept C2779784034 @default.
• W4308997383 hasConcept C55493867 @default.
• W4308997383 hasConcept C556039675 @default.
• W4308997383 hasConcept C71924100 @default.
• W4308997383 hasConcept C8891405 @default.
• W4308997383 hasConcept C98274493 @default.
• W4308997383 hasConceptScore W4308997383C126322002 @default.
• W4308997383 hasConceptScore W4308997383C178790620 @default.
• W4308997383 hasConceptScore W4308997383C185592680 @default.
• W4308997383 hasConceptScore W4308997383C203014093 @default.
• W4308997383 hasConceptScore W4308997383C206139338 @default.

• next