FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308997802> ?p ?o ?g. }

• W4308997802 abstract "Progranulin has been considered to be a poor prognostic biomarker for some types of malignancies. However, the clinical significance of serum progranulin level and the prognostic value are still not explored in advanced stages of lung cancer. The current study investigates the prognostic significance of progranulin serum levels in advanced-stage non-small cell lung cancer (NSCLC) patients. This study involved 94 subjects (70 advanced-stage NSCLC patients and 24 healthy controls). Serum progranulin level was measured by enzyme-linked immunosorbent assay (ELISA) and was correlated with patient outcome. The association between circulating progranulin level and clinicopathological parameters was detected. Serum progranulin cut-off level predicting six-month survival was determined. Serum progranulin level was found significantly elevated in NSCLC patients than in the control group (p<0.001). We did not determine a significant difference between stage IIIB and stage IV NSCLC patients for serum progranulin levels (p=0.166). When we evaluated the laboratory parameters, only serum LDH level was found significantly correlated with serum progranulin level (p=0.043), also bone and liver metastasis showed a significant correlation with progranulin level (p=0.008 and p = 0.024, respectively). The cut-off level of serum progranulin in predicting six months of survival was determined as 16.03 ng/ml (AUC = 0.973, 95%Cl: 0.903-0.997, p<0.001) with 97.06% sensitivity and 88.89% specificity. Overall survival was determined shorter in patients with progranulin level ≥16 ng/ml than those with <16 ng/ml (p<0.001). Also, in the multivariate analysis using the Cox regression model serum progranulin level was found as an independent prognostic factor for NSCLC (p=0.001). Serum progranulin level may be a useful biomarker for predicting poor survival in advanced-stage NSCLC patients." @default.
• W4308997802 created "2022-11-20" @default.
• W4308997802 creator A5019800401 @default.
• W4308997802 creator A5028952467 @default.
• W4308997802 creator A5030816705 @default.
• W4308997802 creator A5068124899 @default.
• W4308997802 creator A5083932293 @default.
• W4308997802 date "2022-11-14" @default.
• W4308997802 modified "2023-10-18" @default.
• W4308997802 title "Can serum progranulin level be used as a prognostic biomarker in non-small cell lung cancer?" @default.
• W4308997802 cites W1549118814 @default.
• W4308997802 cites W1971016258 @default.
• W4308997802 cites W2063449452 @default.
• W4308997802 cites W2094706373 @default.
• W4308997802 cites W2107290336 @default.
• W4308997802 cites W2143500555 @default.
• W4308997802 cites W2251438188 @default.
• W4308997802 cites W2483451962 @default.
• W4308997802 cites W2508128724 @default.
• W4308997802 cites W2515969222 @default.
• W4308997802 cites W2558669106 @default.
• W4308997802 cites W2689907640 @default.
• W4308997802 cites W2747578239 @default.
• W4308997802 cites W2767914339 @default.
• W4308997802 cites W2894705949 @default.
• W4308997802 cites W2898386618 @default.
• W4308997802 cites W2971444951 @default.
• W4308997802 cites W2999417355 @default.
• W4308997802 cites W3016652041 @default.
• W4308997802 cites W3037163607 @default.
• W4308997802 cites W3132889141 @default.
• W4308997802 cites W3194782879 @default.
• W4308997802 cites W4206106951 @default.
• W4308997802 doi "https://doi.org/10.4081/monaldi.2022.2373" @default.
• W4308997802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36382807" @default.
• W4308997802 hasPublicationYear "2022" @default.
• W4308997802 type Work @default.
• W4308997802 citedByCount "0" @default.
• W4308997802 crossrefType "journal-article" @default.
• W4308997802 hasAuthorship W4308997802A5019800401 @default.
• W4308997802 hasAuthorship W4308997802A5028952467 @default.
• W4308997802 hasAuthorship W4308997802A5030816705 @default.
• W4308997802 hasAuthorship W4308997802A5068124899 @default.
• W4308997802 hasAuthorship W4308997802A5083932293 @default.
• W4308997802 hasBestOaLocation W43089978021 @default.
• W4308997802 hasConcept C121608353 @default.
• W4308997802 hasConcept C126322002 @default.
• W4308997802 hasConcept C142724271 @default.
• W4308997802 hasConcept C143998085 @default.
• W4308997802 hasConcept C146357865 @default.
• W4308997802 hasConcept C151730666 @default.
• W4308997802 hasConcept C2776256026 @default.
• W4308997802 hasConcept C2777714996 @default.
• W4308997802 hasConcept C2781197716 @default.
• W4308997802 hasConcept C55493867 @default.
• W4308997802 hasConcept C63363279 @default.
• W4308997802 hasConcept C71924100 @default.
• W4308997802 hasConcept C86803240 @default.
• W4308997802 hasConcept C90924648 @default.
• W4308997802 hasConceptScore W4308997802C121608353 @default.
• W4308997802 hasConceptScore W4308997802C126322002 @default.
• W4308997802 hasConceptScore W4308997802C142724271 @default.
• W4308997802 hasConceptScore W4308997802C143998085 @default.
• W4308997802 hasConceptScore W4308997802C146357865 @default.
• W4308997802 hasConceptScore W4308997802C151730666 @default.
• W4308997802 hasConceptScore W4308997802C2776256026 @default.
• W4308997802 hasConceptScore W4308997802C2777714996 @default.
• W4308997802 hasConceptScore W4308997802C2781197716 @default.
• W4308997802 hasConceptScore W4308997802C55493867 @default.
• W4308997802 hasConceptScore W4308997802C63363279 @default.
• W4308997802 hasConceptScore W4308997802C71924100 @default.
• W4308997802 hasConceptScore W4308997802C86803240 @default.
• W4308997802 hasConceptScore W4308997802C90924648 @default.
• W4308997802 hasLocation W43089978021 @default.
• W4308997802 hasLocation W43089978022 @default.
• W4308997802 hasOpenAccess W4308997802 @default.
• W4308997802 hasPrimaryLocation W43089978021 @default.
• W4308997802 hasRelatedWork W1967103478 @default.
• W4308997802 hasRelatedWork W2032912323 @default.
• W4308997802 hasRelatedWork W2348266771 @default.
• W4308997802 hasRelatedWork W2348529436 @default.
• W4308997802 hasRelatedWork W2354400911 @default.
• W4308997802 hasRelatedWork W2356105190 @default.
• W4308997802 hasRelatedWork W2372561159 @default.
• W4308997802 hasRelatedWork W2375344515 @default.
• W4308997802 hasRelatedWork W2390152934 @default.
• W4308997802 hasRelatedWork W2937519691 @default.
• W4308997802 isParatext "false" @default.
• W4308997802 isRetracted "false" @default.
• W4308997802 workType "article" @default.