Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308998416> ?p ?o ?g. }
- W4308998416 endingPage "017002" @default.
- W4308998416 startingPage "017002" @default.
- W4308998416 abstract "Abstract Multi-organ-on-a-chip devices have attracted extensive attention because they hold great potential for advancing drug discovery and development by recapitulating human physiological conditions. However, they often lack on-chip analytical technologies for the in situ non-invasive real-time monitoring of organ tissue responses to pharmaceutical compounds over extended durations. Here, we introduce the microfabrication of a multi-organ-on-a-chip by integrating two indispensable components into a polydimethylsiloxane (PDMS)-based microfluidic device: a pneumatic-actuated micropump to generate a circulation flow for organ-organ interaction and a parylene-insulated microelectrode array (MEA) for electrophysiological analysis. We demonstrated that the pumping performance of the micropump was sufficient for recapitulating the metabolite interaction, and the measured impedance magnitude was comparable to that of state-of-the-art MEA devices. The experimental results suggest that the present microfabrication has potential applications such as the measurement of electrophysiological parameters under recapitulating metabolite interaction, enabling more comprehensive drug testing in vitro." @default.
- W4308998416 created "2022-11-20" @default.
- W4308998416 creator A5006660708 @default.
- W4308998416 creator A5023126951 @default.
- W4308998416 creator A5064074469 @default.
- W4308998416 creator A5081234240 @default.
- W4308998416 creator A5090508999 @default.
- W4308998416 creator A5045184002 @default.
- W4308998416 date "2022-12-15" @default.
- W4308998416 modified "2023-09-29" @default.
- W4308998416 title "Microfabrication of polydimethylsiloxane–parylene hybrid microelectrode array integrated into a multi-organ-on-a-chip" @default.
- W4308998416 cites W1546671514 @default.
- W4308998416 cites W1612694341 @default.
- W4308998416 cites W1970473335 @default.
- W4308998416 cites W1977046933 @default.
- W4308998416 cites W1982759742 @default.
- W4308998416 cites W1992990797 @default.
- W4308998416 cites W1997218466 @default.
- W4308998416 cites W2010546163 @default.
- W4308998416 cites W2013520568 @default.
- W4308998416 cites W2024209309 @default.
- W4308998416 cites W2027910517 @default.
- W4308998416 cites W2031383358 @default.
- W4308998416 cites W2032115883 @default.
- W4308998416 cites W2034437976 @default.
- W4308998416 cites W2037660499 @default.
- W4308998416 cites W2039001850 @default.
- W4308998416 cites W2039045089 @default.
- W4308998416 cites W2046908617 @default.
- W4308998416 cites W2047881676 @default.
- W4308998416 cites W2050186707 @default.
- W4308998416 cites W2056429799 @default.
- W4308998416 cites W2071311642 @default.
- W4308998416 cites W2074826409 @default.
- W4308998416 cites W2079113065 @default.
- W4308998416 cites W2081152019 @default.
- W4308998416 cites W2082745694 @default.
- W4308998416 cites W2107542980 @default.
- W4308998416 cites W2114047305 @default.
- W4308998416 cites W2114997850 @default.
- W4308998416 cites W2116208923 @default.
- W4308998416 cites W2126012359 @default.
- W4308998416 cites W2126875247 @default.
- W4308998416 cites W2129884263 @default.
- W4308998416 cites W2135400595 @default.
- W4308998416 cites W2136682738 @default.
- W4308998416 cites W2136733158 @default.
- W4308998416 cites W2148366851 @default.
- W4308998416 cites W2153650331 @default.
- W4308998416 cites W2167287337 @default.
- W4308998416 cites W2169428322 @default.
- W4308998416 cites W2172838120 @default.
- W4308998416 cites W2275627638 @default.
- W4308998416 cites W2289031597 @default.
- W4308998416 cites W2339436037 @default.
- W4308998416 cites W241683524 @default.
- W4308998416 cites W2528336050 @default.
- W4308998416 cites W2529651509 @default.
- W4308998416 cites W2551814827 @default.
- W4308998416 cites W2601329859 @default.
- W4308998416 cites W2607163305 @default.
- W4308998416 cites W2618400336 @default.
- W4308998416 cites W2621842261 @default.
- W4308998416 cites W2738210390 @default.
- W4308998416 cites W2760380198 @default.
- W4308998416 cites W2765538948 @default.
- W4308998416 cites W2772233670 @default.
- W4308998416 cites W2791080218 @default.
- W4308998416 cites W2791453856 @default.
- W4308998416 cites W2793367223 @default.
- W4308998416 cites W2796074158 @default.
- W4308998416 cites W2799773965 @default.
- W4308998416 cites W2888088501 @default.
- W4308998416 cites W2892769345 @default.
- W4308998416 cites W2896198442 @default.
- W4308998416 cites W2901973720 @default.
- W4308998416 cites W2902240538 @default.
- W4308998416 cites W2902585499 @default.
- W4308998416 cites W2905693259 @default.
- W4308998416 cites W2909633774 @default.
- W4308998416 cites W2910246371 @default.
- W4308998416 cites W2912840511 @default.
- W4308998416 cites W2920104240 @default.
- W4308998416 cites W2922159564 @default.
- W4308998416 cites W2938384627 @default.
- W4308998416 cites W2981555985 @default.
- W4308998416 cites W2982621866 @default.
- W4308998416 cites W2995566971 @default.
- W4308998416 cites W2997687538 @default.
- W4308998416 cites W3011891279 @default.
- W4308998416 cites W3022294525 @default.
- W4308998416 cites W3042949185 @default.
- W4308998416 cites W3045243723 @default.
- W4308998416 cites W3087447424 @default.
- W4308998416 cites W3109472323 @default.
- W4308998416 cites W3121338058 @default.
- W4308998416 cites W3122854086 @default.
- W4308998416 cites W3127663283 @default.