Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308998436> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4308998436 endingPage "129067" @default.
- W4308998436 startingPage "129067" @default.
- W4308998436 abstract "A novel series of α7 nicotinic acetylcholine receptor (nAChR) modulators was designed and evaluated for antitussive activity in an in vivo guinea pig model of chemically induced cough. Compound 16 at all tested doses (9.5, 3 and 1 mg/kg) significantly (p < 0.01) reduced the cumulative number of coughs and showed similar results to a positive control (codeine at 30 mg/kg). Among three different administration routes (intraperitoneal, oral and inhalation), compound 16 exerted a significant antitussive effect in guinea pigs at an inhaled dose as low as 0.4 mg/kg (p < 0.05). α7 nAChR modulators may provide a novel, non-narcotic approach to therapy in patients with acute and chronic cough." @default.
- W4308998436 created "2022-11-20" @default.
- W4308998436 creator A5035691642 @default.
- W4308998436 creator A5050751302 @default.
- W4308998436 creator A5087038430 @default.
- W4308998436 creator A5088120914 @default.
- W4308998436 date "2023-01-01" @default.
- W4308998436 modified "2023-10-12" @default.
- W4308998436 title "Novel α7 nicotinic acetylcholine receptor modulators as potential antitussive agents" @default.
- W4308998436 cites W1908992399 @default.
- W4308998436 cites W1963597328 @default.
- W4308998436 cites W1964072039 @default.
- W4308998436 cites W1977367528 @default.
- W4308998436 cites W2026286337 @default.
- W4308998436 cites W2046775696 @default.
- W4308998436 cites W2061287334 @default.
- W4308998436 cites W2072012688 @default.
- W4308998436 cites W2168457138 @default.
- W4308998436 cites W2784297905 @default.
- W4308998436 cites W3037222642 @default.
- W4308998436 cites W3038746667 @default.
- W4308998436 cites W3047411841 @default.
- W4308998436 cites W3212249613 @default.
- W4308998436 cites W4238596965 @default.
- W4308998436 doi "https://doi.org/10.1016/j.bmcl.2022.129067" @default.
- W4308998436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395996" @default.
- W4308998436 hasPublicationYear "2023" @default.
- W4308998436 type Work @default.
- W4308998436 citedByCount "1" @default.
- W4308998436 countsByYear W43089984362023 @default.
- W4308998436 crossrefType "journal-article" @default.
- W4308998436 hasAuthorship W4308998436A5035691642 @default.
- W4308998436 hasAuthorship W4308998436A5050751302 @default.
- W4308998436 hasAuthorship W4308998436A5087038430 @default.
- W4308998436 hasAuthorship W4308998436A5088120914 @default.
- W4308998436 hasConcept C126322002 @default.
- W4308998436 hasConcept C150903083 @default.
- W4308998436 hasConcept C170493617 @default.
- W4308998436 hasConcept C185592680 @default.
- W4308998436 hasConcept C188987157 @default.
- W4308998436 hasConcept C207001950 @default.
- W4308998436 hasConcept C2775910092 @default.
- W4308998436 hasConcept C2777056448 @default.
- W4308998436 hasConcept C2778815084 @default.
- W4308998436 hasConcept C2779570518 @default.
- W4308998436 hasConcept C55493867 @default.
- W4308998436 hasConcept C71924100 @default.
- W4308998436 hasConcept C80161118 @default.
- W4308998436 hasConcept C86803240 @default.
- W4308998436 hasConcept C98274493 @default.
- W4308998436 hasConceptScore W4308998436C126322002 @default.
- W4308998436 hasConceptScore W4308998436C150903083 @default.
- W4308998436 hasConceptScore W4308998436C170493617 @default.
- W4308998436 hasConceptScore W4308998436C185592680 @default.
- W4308998436 hasConceptScore W4308998436C188987157 @default.
- W4308998436 hasConceptScore W4308998436C207001950 @default.
- W4308998436 hasConceptScore W4308998436C2775910092 @default.
- W4308998436 hasConceptScore W4308998436C2777056448 @default.
- W4308998436 hasConceptScore W4308998436C2778815084 @default.
- W4308998436 hasConceptScore W4308998436C2779570518 @default.
- W4308998436 hasConceptScore W4308998436C55493867 @default.
- W4308998436 hasConceptScore W4308998436C71924100 @default.
- W4308998436 hasConceptScore W4308998436C80161118 @default.
- W4308998436 hasConceptScore W4308998436C86803240 @default.
- W4308998436 hasConceptScore W4308998436C98274493 @default.
- W4308998436 hasLocation W43089984361 @default.
- W4308998436 hasLocation W43089984362 @default.
- W4308998436 hasOpenAccess W4308998436 @default.
- W4308998436 hasPrimaryLocation W43089984361 @default.
- W4308998436 hasRelatedWork W1570361834 @default.
- W4308998436 hasRelatedWork W1981881599 @default.
- W4308998436 hasRelatedWork W1983993763 @default.
- W4308998436 hasRelatedWork W2005226742 @default.
- W4308998436 hasRelatedWork W2077339822 @default.
- W4308998436 hasRelatedWork W2134416049 @default.
- W4308998436 hasRelatedWork W2356169571 @default.
- W4308998436 hasRelatedWork W3023630691 @default.
- W4308998436 hasRelatedWork W3126718520 @default.
- W4308998436 hasRelatedWork W4317639052 @default.
- W4308998436 hasVolume "80" @default.
- W4308998436 isParatext "false" @default.
- W4308998436 isRetracted "false" @default.
- W4308998436 workType "article" @default.