Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309001048> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4309001048 endingPage "10" @default.
- W4309001048 startingPage "1" @default.
- W4309001048 abstract "The present study investigates and highlights the potency of tacrolimus (TAC) for effective vitiligo management using cubosome gel formulation. TAC-loaded cubosome formulations were prepared by using the ultrasonication technique. The central composite design (CCD) statistical design was employed for optimization of TAC-loaded cubosome based on responsible variables like particle size and entrapment efficiency. The optimized (F-14) TAC-loaded cubosome was subjected to physicochemical characterizations, including, particle size and zeta potential analysis, SEM, drug loading and drug release profiling assessment. SEM imaging confirmed spherical morphology of TAC loaded cubosome. Drug release percentage from cubosome was found to be with controlled drug release of 73% for 12 hour and release kinetics follows zero-order and Fickian diffusion mechanism. The optimized TAC-loaded cubosome formulation was incorporated in Carbopol 934 for the topical application of TAC-loaded cubosome gel (TAC-CG) for vitiligo. Therapeutic efficacy of TAC-CG for effective control of inflammation in vitiligo condition was assessed using monobenzene (60%) induced model of vitiligo using C57BL/6 mice. TAC-CG treatment exhibited a significant reduction in the depigmentation as a response when compared to that of the monobenzene-sensitized normal control mice." @default.
- W4309001048 created "2022-11-20" @default.
- W4309001048 creator A5005251502 @default.
- W4309001048 creator A5047691490 @default.
- W4309001048 creator A5051383960 @default.
- W4309001048 creator A5081179930 @default.
- W4309001048 date "2022-11-14" @default.
- W4309001048 modified "2023-10-16" @default.
- W4309001048 title "Formulation and characteristic evaluation of tacrolimus cubosomal gel for vitiligo" @default.
- W4309001048 cites W170267546 @default.
- W4309001048 cites W1989036377 @default.
- W4309001048 cites W1993720859 @default.
- W4309001048 cites W2012177545 @default.
- W4309001048 cites W2017035820 @default.
- W4309001048 cites W2019182129 @default.
- W4309001048 cites W2031095463 @default.
- W4309001048 cites W2054498917 @default.
- W4309001048 cites W2064697425 @default.
- W4309001048 cites W2070643173 @default.
- W4309001048 cites W2147584970 @default.
- W4309001048 cites W2157431305 @default.
- W4309001048 cites W2181409630 @default.
- W4309001048 cites W2197752658 @default.
- W4309001048 cites W2210405447 @default.
- W4309001048 cites W2333433465 @default.
- W4309001048 cites W2475913549 @default.
- W4309001048 cites W2493110603 @default.
- W4309001048 cites W2778213823 @default.
- W4309001048 cites W2792966670 @default.
- W4309001048 cites W2803243498 @default.
- W4309001048 cites W2891488942 @default.
- W4309001048 cites W2901476092 @default.
- W4309001048 cites W2918285535 @default.
- W4309001048 cites W2940058582 @default.
- W4309001048 cites W2940561760 @default.
- W4309001048 cites W3000591474 @default.
- W4309001048 cites W3012531490 @default.
- W4309001048 cites W3022951410 @default.
- W4309001048 cites W3087933272 @default.
- W4309001048 cites W3089977133 @default.
- W4309001048 cites W3113042459 @default.
- W4309001048 cites W3119859840 @default.
- W4309001048 cites W3131095989 @default.
- W4309001048 cites W3158275130 @default.
- W4309001048 cites W3158869560 @default.
- W4309001048 cites W3163021069 @default.
- W4309001048 cites W4223557378 @default.
- W4309001048 cites W4226111841 @default.
- W4309001048 cites W4226115320 @default.
- W4309001048 cites W4289203941 @default.
- W4309001048 doi "https://doi.org/10.1080/01932691.2022.2139716" @default.
- W4309001048 hasPublicationYear "2022" @default.
- W4309001048 type Work @default.
- W4309001048 citedByCount "2" @default.
- W4309001048 countsByYear W43090010482023 @default.
- W4309001048 crossrefType "journal-article" @default.
- W4309001048 hasAuthorship W4309001048A5005251502 @default.
- W4309001048 hasAuthorship W4309001048A5047691490 @default.
- W4309001048 hasAuthorship W4309001048A5051383960 @default.
- W4309001048 hasAuthorship W4309001048A5081179930 @default.
- W4309001048 hasBestOaLocation W43090010482 @default.
- W4309001048 hasConcept C147789679 @default.
- W4309001048 hasConcept C16005928 @default.
- W4309001048 hasConcept C185592680 @default.
- W4309001048 hasConcept C187530423 @default.
- W4309001048 hasConcept C2776972258 @default.
- W4309001048 hasConcept C2779980618 @default.
- W4309001048 hasConcept C71924100 @default.
- W4309001048 hasConcept C98274493 @default.
- W4309001048 hasConceptScore W4309001048C147789679 @default.
- W4309001048 hasConceptScore W4309001048C16005928 @default.
- W4309001048 hasConceptScore W4309001048C185592680 @default.
- W4309001048 hasConceptScore W4309001048C187530423 @default.
- W4309001048 hasConceptScore W4309001048C2776972258 @default.
- W4309001048 hasConceptScore W4309001048C2779980618 @default.
- W4309001048 hasConceptScore W4309001048C71924100 @default.
- W4309001048 hasConceptScore W4309001048C98274493 @default.
- W4309001048 hasLocation W43090010481 @default.
- W4309001048 hasLocation W43090010482 @default.
- W4309001048 hasOpenAccess W4309001048 @default.
- W4309001048 hasPrimaryLocation W43090010481 @default.
- W4309001048 hasRelatedWork W1490978052 @default.
- W4309001048 hasRelatedWork W1536350585 @default.
- W4309001048 hasRelatedWork W1555157092 @default.
- W4309001048 hasRelatedWork W1981205945 @default.
- W4309001048 hasRelatedWork W2021952861 @default.
- W4309001048 hasRelatedWork W2066464304 @default.
- W4309001048 hasRelatedWork W2637456622 @default.
- W4309001048 hasRelatedWork W4241512831 @default.
- W4309001048 hasRelatedWork W4363677409 @default.
- W4309001048 hasRelatedWork W4383114360 @default.
- W4309001048 isParatext "false" @default.
- W4309001048 isRetracted "false" @default.
- W4309001048 workType "article" @default.