FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309011636> ?p ?o ?g. }

• W4309011636 endingPage "2137" @default.
• W4309011636 startingPage "2122" @default.
• W4309011636 abstract "Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide. Synaptophysin-like 2 (SYPL2) is a neuroendocrine-related protein highly expressed in skeletal muscle and the tongue. The involvement of SYPL2 in CRC, including its level of expression and function, has not been evaluated.To evaluate the correlations of SYPL2 expression with lymph node metastasis (LNM) and prognosis in patients with CRC.The levels of expression of SYPL2 in CRC and normal colorectal tissues were analyzed in multiple public and online databases. The associations between clinical variables and SYPL2 expression were evaluated statistically, and the associations between SYPL2 expression and prognosis in patients with CRC were analyzed using the Kaplan-Meier method and univariate/multivariate Cox regression analyses. SYPL2 expression was assessed in 20 paired CRC tissue and adjacent normal colorectal tissue samples obtained from Fuyang People's Hospital, and the associations between SYPL2 expression and the clinical characteristics of these patients were investigated. Correlations between the levels of expression of SYPL2 and key targeted genes were determined by Pearson's correlation analysis. The distribution of immune cells in these samples was calculated using the CIBERSORT algorithm. Gene set enrichment analysis (GSEA) was performed to evaluate the biofunction and pathways of SYPL2 in CRC.SYPL2 expression was significantly lower in CRC tissue samples than in normal colorectal tissue samples (P < 0.05). High SYPL2 levels in CRC tissues correlated significantly with LNM (P < 0.05) and a poorer patient prognosis, including significantly shorter overall survival (OS) [hazard ratio (HR) = 1.9, P < 0.05] and disease-free survival (HR = 1.6, P < 0.05). High SYPL2 expression was an independent risk factor for OS in both univariate (HR = 2.078, P = 0.014) and multivariate (HR = 1.754, P = 0.018) Cox regression analyses. In addition, SYPL2 expression correlated significantly with the expression of KDR (P < 0.0001, r = 0.47) and the BRAFV600E mutation (P < 0.05). Higher SYPL2 expression was associated with the enrichment of CD8 T-cells and M0 macrophages in the tumor microenvironment. GSEA revealed that SYPL2 was associated with the regulation of epithelial cell migration, vasculature development, pathways in cancer, and several vital tumor-related pathways.SYPL2 expression was lower in CRC tissue than in normal colorectal tissue. Higher SYPL2 expression in CRC was significantly associated with LNM and poorer survival." @default.
• W4309011636 created "2022-11-20" @default.
• W4309011636 creator A5002159311 @default.
• W4309011636 creator A5023005054 @default.
• W4309011636 creator A5027184984 @default.
• W4309011636 creator A5051162009 @default.
• W4309011636 date "2022-11-15" @default.
• W4309011636 modified "2023-09-30" @default.
• W4309011636 title "Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients" @default.
• W4309011636 cites W1990423062 @default.
• W4309011636 cites W2028807910 @default.
• W4309011636 cites W2052352402 @default.
• W4309011636 cites W2054737774 @default.
• W4309011636 cites W2068699402 @default.
• W4309011636 cites W2084205842 @default.
• W4309011636 cites W2119938514 @default.
• W4309011636 cites W2155492044 @default.
• W4309011636 cites W2507880739 @default.
• W4309011636 cites W2584455808 @default.
• W4309011636 cites W2737749184 @default.
• W4309011636 cites W2782675598 @default.
• W4309011636 cites W2889892812 @default.
• W4309011636 cites W2897301108 @default.
• W4309011636 cites W2953882293 @default.
• W4309011636 cites W2969669738 @default.
• W4309011636 cites W3009963727 @default.
• W4309011636 cites W3013389750 @default.
• W4309011636 cites W3033872896 @default.
• W4309011636 cites W3039450521 @default.
• W4309011636 cites W3039693333 @default.
• W4309011636 cites W3044737312 @default.
• W4309011636 cites W3091900404 @default.
• W4309011636 cites W3092115627 @default.
• W4309011636 cites W3130224122 @default.
• W4309011636 cites W3134887329 @default.
• W4309011636 cites W3135981899 @default.
• W4309011636 cites W3148370335 @default.
• W4309011636 cites W3157185054 @default.
• W4309011636 cites W3159454489 @default.
• W4309011636 cites W3186080079 @default.
• W4309011636 cites W4206841660 @default.
• W4309011636 cites W4211121451 @default.
• W4309011636 cites W4211133582 @default.
• W4309011636 cites W4211199921 @default.
• W4309011636 cites W4244315786 @default.
• W4309011636 doi "https://doi.org/10.4251/wjgo.v14.i11.2122" @default.
• W4309011636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36438706" @default.
• W4309011636 hasPublicationYear "2022" @default.
• W4309011636 type Work @default.
• W4309011636 citedByCount "0" @default.
• W4309011636 crossrefType "journal-article" @default.
• W4309011636 hasAuthorship W4309011636A5002159311 @default.
• W4309011636 hasAuthorship W4309011636A5023005054 @default.
• W4309011636 hasAuthorship W4309011636A5027184984 @default.
• W4309011636 hasAuthorship W4309011636A5051162009 @default.
• W4309011636 hasBestOaLocation W43090116361 @default.
• W4309011636 hasConcept C10515644 @default.
• W4309011636 hasConcept C121608353 @default.
• W4309011636 hasConcept C126322002 @default.
• W4309011636 hasConcept C143998085 @default.
• W4309011636 hasConcept C144301174 @default.
• W4309011636 hasConcept C204232928 @default.
• W4309011636 hasConcept C207103383 @default.
• W4309011636 hasConcept C2777209535 @default.
• W4309011636 hasConcept C2779013556 @default.
• W4309011636 hasConcept C38180746 @default.
• W4309011636 hasConcept C44249647 @default.
• W4309011636 hasConcept C50382708 @default.
• W4309011636 hasConcept C526805850 @default.
• W4309011636 hasConcept C71924100 @default.
• W4309011636 hasConceptScore W4309011636C10515644 @default.
• W4309011636 hasConceptScore W4309011636C121608353 @default.
• W4309011636 hasConceptScore W4309011636C126322002 @default.
• W4309011636 hasConceptScore W4309011636C143998085 @default.
• W4309011636 hasConceptScore W4309011636C144301174 @default.
• W4309011636 hasConceptScore W4309011636C204232928 @default.
• W4309011636 hasConceptScore W4309011636C207103383 @default.
• W4309011636 hasConceptScore W4309011636C2777209535 @default.
• W4309011636 hasConceptScore W4309011636C2779013556 @default.
• W4309011636 hasConceptScore W4309011636C38180746 @default.
• W4309011636 hasConceptScore W4309011636C44249647 @default.
• W4309011636 hasConceptScore W4309011636C50382708 @default.
• W4309011636 hasConceptScore W4309011636C526805850 @default.
• W4309011636 hasConceptScore W4309011636C71924100 @default.
• W4309011636 hasIssue "11" @default.
• W4309011636 hasLocation W43090116361 @default.
• W4309011636 hasLocation W43090116362 @default.
• W4309011636 hasLocation W43090116363 @default.
• W4309011636 hasOpenAccess W4309011636 @default.
• W4309011636 hasPrimaryLocation W43090116361 @default.
• W4309011636 hasRelatedWork W2056185445 @default.
• W4309011636 hasRelatedWork W2128245076 @default.
• W4309011636 hasRelatedWork W2150205536 @default.
• W4309011636 hasRelatedWork W2361700749 @default.
• W4309011636 hasRelatedWork W2375628929 @default.
• W4309011636 hasRelatedWork W2386134303 @default.
• W4309011636 hasRelatedWork W2405817813 @default.
• W4309011636 hasRelatedWork W2607758844 @default.

• next