Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309022577> ?p ?o ?g. }
- W4309022577 endingPage "122402" @default.
- W4309022577 startingPage "122402" @default.
- W4309022577 abstract "A significant contributor to cancer-related death globally is metastatic breast cancer. To reduce death rates, tumor-specific penetration and triggered drug release are crucial. Herein, targeted intracellular doxorubicin (Dox) delivery system was effectively prepared based on redox-sensitive hyaluronic acid-palmitoyl (HA-ss-PA) copolymers. The amphiphilic copolymers self-assembled into nano and showed outstanding drug-loading capacities and encapsulation efficiency for Dox. Micelles were stable under physiological conditions, but they quickly disintegrated in the presence of a reducing agent. The intracellular location of the fluorescent probe rhodamine b demonstrated that HA-ss-PA micelles are an efficient approach for drug delivery in breast cancer cells. Based on flow cytometry and live/dead assay, observations indicated that micelles induce apoptosis in both MCF-7 and MDA-MB-231 cells. In vivo evaluation in tumor-bearing mice confirmed that HA-ss-PA micelles exhibited excellent tumor-targeting activity. These findings imply that redox-sensitive HA-ss-PA micelles are promising candidates for use as intracellular delivery systems for hydrophobic anti-cancer drugs." @default.
- W4309022577 created "2022-11-21" @default.
- W4309022577 creator A5034780635 @default.
- W4309022577 creator A5081276472 @default.
- W4309022577 date "2022-12-01" @default.
- W4309022577 modified "2023-09-23" @default.
- W4309022577 title "Redox-Sensitive multifunctional hyaluronic acid-based nanomicelles with Fine-controlled anticancer drug release" @default.
- W4309022577 cites W1976073542 @default.
- W4309022577 cites W1985634815 @default.
- W4309022577 cites W2004680537 @default.
- W4309022577 cites W2054547205 @default.
- W4309022577 cites W2090520288 @default.
- W4309022577 cites W2157743198 @default.
- W4309022577 cites W2159490365 @default.
- W4309022577 cites W2161913128 @default.
- W4309022577 cites W2178109679 @default.
- W4309022577 cites W2272216542 @default.
- W4309022577 cites W2306682522 @default.
- W4309022577 cites W2421427208 @default.
- W4309022577 cites W2492805479 @default.
- W4309022577 cites W2586407709 @default.
- W4309022577 cites W2589269825 @default.
- W4309022577 cites W2605677864 @default.
- W4309022577 cites W2750717426 @default.
- W4309022577 cites W2791589691 @default.
- W4309022577 cites W2792385897 @default.
- W4309022577 cites W2801737525 @default.
- W4309022577 cites W2891351185 @default.
- W4309022577 cites W2904160357 @default.
- W4309022577 cites W2909344598 @default.
- W4309022577 cites W2912498912 @default.
- W4309022577 cites W2917676741 @default.
- W4309022577 cites W2924113246 @default.
- W4309022577 cites W2948008915 @default.
- W4309022577 cites W2964770151 @default.
- W4309022577 cites W2987465679 @default.
- W4309022577 cites W3007210350 @default.
- W4309022577 cites W3009714181 @default.
- W4309022577 cites W3010824984 @default.
- W4309022577 cites W3026635829 @default.
- W4309022577 cites W3048741752 @default.
- W4309022577 cites W3082261823 @default.
- W4309022577 cites W3088847182 @default.
- W4309022577 cites W3099846680 @default.
- W4309022577 cites W3123631538 @default.
- W4309022577 cites W3128646645 @default.
- W4309022577 cites W3137376641 @default.
- W4309022577 cites W3162924348 @default.
- W4309022577 cites W3168084424 @default.
- W4309022577 cites W3199367594 @default.
- W4309022577 cites W4200376172 @default.
- W4309022577 cites W4288045997 @default.
- W4309022577 cites W4288809652 @default.
- W4309022577 cites W865178568 @default.
- W4309022577 doi "https://doi.org/10.1016/j.ijpharm.2022.122402" @default.
- W4309022577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395923" @default.
- W4309022577 hasPublicationYear "2022" @default.
- W4309022577 type Work @default.
- W4309022577 citedByCount "5" @default.
- W4309022577 countsByYear W43090225772023 @default.
- W4309022577 crossrefType "journal-article" @default.
- W4309022577 hasAuthorship W4309022577A5034780635 @default.
- W4309022577 hasAuthorship W4309022577A5081276472 @default.
- W4309022577 hasConcept C11268172 @default.
- W4309022577 hasConcept C121608353 @default.
- W4309022577 hasConcept C12554922 @default.
- W4309022577 hasConcept C133936738 @default.
- W4309022577 hasConcept C150903083 @default.
- W4309022577 hasConcept C153911025 @default.
- W4309022577 hasConcept C178790620 @default.
- W4309022577 hasConcept C184651966 @default.
- W4309022577 hasConcept C185592680 @default.
- W4309022577 hasConcept C207001950 @default.
- W4309022577 hasConcept C2776694085 @default.
- W4309022577 hasConcept C2777529286 @default.
- W4309022577 hasConcept C2778589691 @default.
- W4309022577 hasConcept C2779820397 @default.
- W4309022577 hasConcept C2780035454 @default.
- W4309022577 hasConcept C2781303535 @default.
- W4309022577 hasConcept C501593827 @default.
- W4309022577 hasConcept C54355233 @default.
- W4309022577 hasConcept C553184892 @default.
- W4309022577 hasConcept C55493867 @default.
- W4309022577 hasConcept C79879829 @default.
- W4309022577 hasConcept C86803240 @default.
- W4309022577 hasConcept C96232424 @default.
- W4309022577 hasConcept C98274493 @default.
- W4309022577 hasConceptScore W4309022577C11268172 @default.
- W4309022577 hasConceptScore W4309022577C121608353 @default.
- W4309022577 hasConceptScore W4309022577C12554922 @default.
- W4309022577 hasConceptScore W4309022577C133936738 @default.
- W4309022577 hasConceptScore W4309022577C150903083 @default.
- W4309022577 hasConceptScore W4309022577C153911025 @default.
- W4309022577 hasConceptScore W4309022577C178790620 @default.
- W4309022577 hasConceptScore W4309022577C184651966 @default.
- W4309022577 hasConceptScore W4309022577C185592680 @default.
- W4309022577 hasConceptScore W4309022577C207001950 @default.
- W4309022577 hasConceptScore W4309022577C2776694085 @default.