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• W4309030597 endingPage "103981" @default.
• W4309030597 startingPage "103981" @default.
• W4309030597 abstract "In wake of antimicrobial resistance (AMR), the present study evaluated the antimicrobial efficacy of chitosan-encapsulated Cecropin-A (1–7)-melittin-cell penetrating peptide (ENC CAMA-CPP) against multi-drug-resistant (MDR) Salmonella Enteritidis. The ENC CAMA-CPP synthesized by ionic gelation technique revealed a particle size of 597.5 ± 13.20 nm and zeta potential of 2.80 ± 0.12 mV. The functional groups including encapsulation confirmation and morphology were evident by Fourier transform infrared spectroscopy and scanning electron microscopy, respectively. On HPLC analysis, an encapsulation efficiency of 75.12 ± 1.52% was observed. Further, a pH-dependent sustained release along with a maximum release of 97% was evident at pH ≥ 8.0 up to 120 h. In vitro, ENC CAMA-CPP was found stable against protease enzymes (trypsin and proteinase K) and biological fluids (simulated gastric fluid and simulated intestinal fluid) and was also tested safe for sheep RBCs, mammalian cells, and beneficial lactobacilli. In the in vitro time-kill assay, ENC CAMA-CPP eliminated intracellular MDR S. Enteritidis at 12 h p.i., while in the in vivo Galleria mellonella larvae model, an improved survival rate, reduced bacterial count, with significant (p < 0.001) immunomodulatory effect and minimal cytotoxicity were evident for ENC CAMA-CPP. Overall, ENC CAMA-CPP appears to be a promising therapeutic candidate against MDR S. Enteritidis and warrants further validation in an appropriate animal model." @default.
• W4309030597 created "2022-11-21" @default.
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• W4309030597 date "2022-12-01" @default.
• W4309030597 modified "2023-10-01" @default.
• W4309030597 title "Antimicrobial efficacy of chitosan encapsulated Cecropin- A (1–7)- melittin-cell-penetrating peptide against multi-drug-resistant Salmonella Enteritidis" @default.
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• W4309030597 doi "https://doi.org/10.1016/j.jddst.2022.103981" @default.
• W4309030597 hasPublicationYear "2022" @default.
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