FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309043072> ?p ?o ?g. }

• W4309043072 abstract "Reperfusion therapy after myocardial infarction may lead to myocardial injury, which can be complicated and exacerbated by diabetes. The existing therapeutic methods for myocardial ischemia-reperfusion injury (MIRI) in diabetic patients are not ideal. Oleoylethanolamide (OEA) has been found to have protective effects on diabetes and acute cerebral ischemia. This study aimed to determine whether OEA can alleviate MIRI in diabetic rats, and to explore the underlying mechanism. The model of diabetic rats with MIRI was established by blocking the left coronary artery for 30 min, followed by restoring blood flow stability for 120 min. The myocardial enzyme spectrum, area of MIRI, and expression levels of apoptosis-related proteins were detected. The results showed that OEA pretreatment could reduce myocardial infarction area, protect myocardial tissue structure, and reduce myocardial cell apoptosis in diabetic rats with MIRI. Meanwhile, the levels of creatine kinase (CK)-MB (CK-MB), lactate dehydrogenase (LDH), and malondialdehyde (MDA) were reduced, while superoxide dismutase (SOD) level was elevated. H9C2 cells were treated with high glucose and oxygen-glucose deprivation/reperfusion (OGD/R) to establish an in vitro model. Capsazepine (CPZ), an antagonist of transient receptor potential vanilloid subtype 1 (TRPV1), and LY294002, an inhibitor of PI3K, were used to treat H9C2 cells in vitro. Apoptosis level and the expression levels of apoptosis-related proteins were measured. It was found that OEA activated TRPV1 and the PI3K/Akt signaling pathway, downregulated the expression levels of apoptosis-related proteins (Bcl-2 and cleaved caspase-3), and ameliorated the apoptosis of H9C2 cells treated with high glucose and OGD/R. This study clarified that OEA, as a TRPV1 agonist, could reduce myocardial cell apoptosis by activating the PI3K/Akt signaling pathway in diabetic rats with MIRI. The findings may provide a theoretical basis for administration of OEA as a potential therapeutic agent into diabetic patients with MIRI." @default.
• W4309043072 created "2022-11-21" @default.
• W4309043072 creator A5008642497 @default.
• W4309043072 creator A5027514192 @default.
• W4309043072 creator A5036547657 @default.
• W4309043072 creator A5043717904 @default.
• W4309043072 creator A5058573916 @default.
• W4309043072 creator A5072441748 @default.
• W4309043072 creator A5077986890 @default.
• W4309043072 creator A5080815038 @default.
• W4309043072 creator A5088788712 @default.
• W4309043072 date "2022-11-14" @default.
• W4309043072 modified "2023-10-18" @default.
• W4309043072 title "OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1" @default.
• W4309043072 cites W1528863037 @default.
• W4309043072 cites W1578641739 @default.
• W4309043072 cites W1987163810 @default.
• W4309043072 cites W1991045646 @default.
• W4309043072 cites W2010560476 @default.
• W4309043072 cites W2041206033 @default.
• W4309043072 cites W2048813801 @default.
• W4309043072 cites W2051757080 @default.
• W4309043072 cites W2053171479 @default.
• W4309043072 cites W2091958169 @default.
• W4309043072 cites W2097199164 @default.
• W4309043072 cites W2098606100 @default.
• W4309043072 cites W2099770880 @default.
• W4309043072 cites W2101099418 @default.
• W4309043072 cites W2103809100 @default.
• W4309043072 cites W2147135453 @default.
• W4309043072 cites W2147791296 @default.
• W4309043072 cites W2153092921 @default.
• W4309043072 cites W2210151709 @default.
• W4309043072 cites W2211563060 @default.
• W4309043072 cites W2219247584 @default.
• W4309043072 cites W2469281193 @default.
• W4309043072 cites W2530261665 @default.
• W4309043072 cites W2531095143 @default.
• W4309043072 cites W2592604112 @default.
• W4309043072 cites W2605198151 @default.
• W4309043072 cites W2611499441 @default.
• W4309043072 cites W2737261996 @default.
• W4309043072 cites W2777913195 @default.
• W4309043072 cites W2793226202 @default.
• W4309043072 cites W2883206008 @default.
• W4309043072 cites W2891950099 @default.
• W4309043072 cites W2895354228 @default.
• W4309043072 cites W2900621847 @default.
• W4309043072 cites W2942365856 @default.
• W4309043072 cites W2963782277 @default.
• W4309043072 cites W2999693109 @default.
• W4309043072 cites W3001192917 @default.
• W4309043072 cites W3005104725 @default.
• W4309043072 cites W3007172221 @default.
• W4309043072 cites W3013096043 @default.
• W4309043072 cites W3034732421 @default.
• W4309043072 cites W3046432268 @default.
• W4309043072 cites W3048325393 @default.
• W4309043072 cites W3104507858 @default.
• W4309043072 cites W3176487105 @default.
• W4309043072 cites W3181877792 @default.
• W4309043072 cites W4224278124 @default.
• W4309043072 doi "https://doi.org/10.3389/fphar.2022.964475" @default.
• W4309043072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36452230" @default.
• W4309043072 hasPublicationYear "2022" @default.
• W4309043072 type Work @default.
• W4309043072 citedByCount "4" @default.
• W4309043072 countsByYear W43090430722023 @default.
• W4309043072 crossrefType "journal-article" @default.
• W4309043072 hasAuthorship W4309043072A5008642497 @default.
• W4309043072 hasAuthorship W4309043072A5027514192 @default.
• W4309043072 hasAuthorship W4309043072A5036547657 @default.
• W4309043072 hasAuthorship W4309043072A5043717904 @default.
• W4309043072 hasAuthorship W4309043072A5058573916 @default.
• W4309043072 hasAuthorship W4309043072A5072441748 @default.
• W4309043072 hasAuthorship W4309043072A5077986890 @default.
• W4309043072 hasAuthorship W4309043072A5080815038 @default.
• W4309043072 hasAuthorship W4309043072A5088788712 @default.
• W4309043072 hasBestOaLocation W43090430721 @default.
• W4309043072 hasConcept C126322002 @default.
• W4309043072 hasConcept C134018914 @default.
• W4309043072 hasConcept C155164980 @default.
• W4309043072 hasConcept C160145004 @default.
• W4309043072 hasConcept C170493617 @default.
• W4309043072 hasConcept C181199279 @default.
• W4309043072 hasConcept C185592680 @default.
• W4309043072 hasConcept C190283241 @default.
• W4309043072 hasConcept C2775838275 @default.
• W4309043072 hasConcept C2776108821 @default.
• W4309043072 hasConcept C2776151105 @default.
• W4309043072 hasConcept C2776912716 @default.
• W4309043072 hasConcept C2777318727 @default.
• W4309043072 hasConcept C2778401633 @default.
• W4309043072 hasConcept C2780071552 @default.
• W4309043072 hasConcept C2780114680 @default.
• W4309043072 hasConcept C36880943 @default.
• W4309043072 hasConcept C541997718 @default.
• W4309043072 hasConcept C55493867 @default.
• W4309043072 hasConcept C71924100 @default.
• W4309043072 hasConcept C75217442 @default.

• next