Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309043609> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4309043609 endingPage "465" @default.
- W4309043609 startingPage "460" @default.
- W4309043609 abstract "This study was designed to examine the effect of different dose of Pentostam administration in male albino mice as a model, todetermine their effect on some biochemical and heamatological parameters. 28 adult male of BALB/c wild mice aged 8- 12 weeks andweighing 25-39 gm were used and i.p. injected with 10mg/kg, 20mg/kg, and 40mg/kg pentostam in addition to a control group. After28 therapeutic days, blood sample were collected from each animal. The result of Biochemical Index of the serum obtained showedthat there were increase significant differences between different concentration doses on AST, ALT, ALP, Urea, Creatinine and BUNas compare to control group at (p >0.01). Conversely in case of Albumin and Total protein were the result showed decrease significantdifference between different concentration doses on this parameter as compare to control group of the same at (p> 0.01). while nosignificant differences between the different concentrations group of doses on Total bilirubin, where the F value was (1.00). The resultof Hematological Index of blood sample showed that there were decrease significant difference at (P ≤ 0.01-0.05) in hemoglobin, HCT,WBCs, LYM and MON concentration in the different concentrations dose of treatment as compared to control group. Conversely, forMCHC, NEU and EOS there were increase significant difference at (P ≤ 0.05-0.01) as compared to the control group. While nosignificant changes (P ≤ 0.0-01.05) in the parameters of RBCs, MCV, MCH, BAS count and Platelet were found when compared withcontrol animals. Biochemical and hematological evaluation pattern still an important role to evaluate drug toxicity. However, theresults of this study concluded that, different doses of Pentostam can cause hepatotoxicity and nephrotoxicity. Therefore, it will beimportant of change in anti-leishmanial regimen to reduce their side effect" @default.
- W4309043609 created "2022-11-21" @default.
- W4309043609 creator A5002746758 @default.
- W4309043609 creator A5009415905 @default.
- W4309043609 creator A5013519840 @default.
- W4309043609 creator A5047205023 @default.
- W4309043609 creator A5082366894 @default.
- W4309043609 date "2022-10-19" @default.
- W4309043609 modified "2023-10-18" @default.
- W4309043609 title "Biochemical And Heamatological Evaluation Pattern Of Pentostam- Induced Hepatotoxicity And Nephrotoxicity In Albino Mice" @default.
- W4309043609 doi "https://doi.org/10.47750/pnr.2022.13.s05.74" @default.
- W4309043609 hasPublicationYear "2022" @default.
- W4309043609 type Work @default.
- W4309043609 citedByCount "0" @default.
- W4309043609 crossrefType "journal-article" @default.
- W4309043609 hasAuthorship W4309043609A5002746758 @default.
- W4309043609 hasAuthorship W4309043609A5009415905 @default.
- W4309043609 hasAuthorship W4309043609A5013519840 @default.
- W4309043609 hasAuthorship W4309043609A5047205023 @default.
- W4309043609 hasAuthorship W4309043609A5082366894 @default.
- W4309043609 hasBestOaLocation W43090436091 @default.
- W4309043609 hasConcept C126189478 @default.
- W4309043609 hasConcept C126322002 @default.
- W4309043609 hasConcept C134018914 @default.
- W4309043609 hasConcept C140793950 @default.
- W4309043609 hasConcept C16685009 @default.
- W4309043609 hasConcept C2776125364 @default.
- W4309043609 hasConcept C2777513400 @default.
- W4309043609 hasConcept C2778917026 @default.
- W4309043609 hasConcept C2780306776 @default.
- W4309043609 hasConcept C29730261 @default.
- W4309043609 hasConcept C3018023364 @default.
- W4309043609 hasConcept C71924100 @default.
- W4309043609 hasConcept C86803240 @default.
- W4309043609 hasConceptScore W4309043609C126189478 @default.
- W4309043609 hasConceptScore W4309043609C126322002 @default.
- W4309043609 hasConceptScore W4309043609C134018914 @default.
- W4309043609 hasConceptScore W4309043609C140793950 @default.
- W4309043609 hasConceptScore W4309043609C16685009 @default.
- W4309043609 hasConceptScore W4309043609C2776125364 @default.
- W4309043609 hasConceptScore W4309043609C2777513400 @default.
- W4309043609 hasConceptScore W4309043609C2778917026 @default.
- W4309043609 hasConceptScore W4309043609C2780306776 @default.
- W4309043609 hasConceptScore W4309043609C29730261 @default.
- W4309043609 hasConceptScore W4309043609C3018023364 @default.
- W4309043609 hasConceptScore W4309043609C71924100 @default.
- W4309043609 hasConceptScore W4309043609C86803240 @default.
- W4309043609 hasLocation W43090436091 @default.
- W4309043609 hasOpenAccess W4309043609 @default.
- W4309043609 hasPrimaryLocation W43090436091 @default.
- W4309043609 hasRelatedWork W2031760864 @default.
- W4309043609 hasRelatedWork W2036439752 @default.
- W4309043609 hasRelatedWork W2181723302 @default.
- W4309043609 hasRelatedWork W2368382074 @default.
- W4309043609 hasRelatedWork W2993320796 @default.
- W4309043609 hasRelatedWork W3097582997 @default.
- W4309043609 hasRelatedWork W4205982474 @default.
- W4309043609 hasRelatedWork W4309043609 @default.
- W4309043609 hasRelatedWork W4366987516 @default.
- W4309043609 hasRelatedWork W3149989027 @default.
- W4309043609 isParatext "false" @default.
- W4309043609 isRetracted "false" @default.
- W4309043609 workType "article" @default.