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- W4309046218 abstract "Summary Chimeric antigen receptor (CAR) T cells have emerged as effective strategy against B cell malignancies. Since the long manufacturing process limits patient accessability, short-term (st) CAR T cells are under investigation. Here, we evaluated CD19-CAR T cells 24 hours after exposure to lentiviral vectors. In co-culture with tumor cells and monocytes, stCAR T cells exhibited anti-tumoral activity and strong release of CRS-relevant cytokines (IL-6, IFN-γ, TNF-α, GM-CSF, IL-2, IL-10). When administered into tumor engrafted NSG-SGM3 mice, severe acute adverse events encompassing high body scoring, temperature and weight drop arised rapidly within 24 hours. Human (IFN-Y, TNF-α, IL-2, IL-10) and murine (MCP-1, IL-6, G-CSF) cytokines typical for severe cytokine release syndrome (CRS) were systemically elevated. Our data highlight potential safety risks of CAR T cells manufactured within short time and suggest simple models for their preclinical safety evaluation." @default.
- W4309046218 created "2022-11-21" @default.
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- W4309046218 date "2022-11-12" @default.
- W4309046218 modified "2023-09-26" @default.
- W4309046218 title "Early induction of cytokine release syndrome by rapidly generated CAR T cells in a preclinical mouse model" @default.
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- W4309046218 doi "https://doi.org/10.1101/2022.11.12.515207" @default.
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