Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309046822> ?p ?o ?g. }
- W4309046822 abstract "The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading to induction of a subset of interferon-induced proteins. We applied DSS (disuccinimidyl suberate) mediated cross-linking mass spectrometry (CLMS) to capture novel protein-protein interactions within the realm of interferon induced proteins. In addition to the expected interferon-induced proteins, we identified novel inter- and intra-molecular cross-linked adducts for the canonical interferon induced proteins, such as MX1, USP18, OAS3, and STAT1. We focused on orthogonal validation of a cohort of novel interferon-induced protein networks formed by the HLA-A protein (H2BFS-HLA-A-HMGA1) using co-immunoprecipitation assay, and further investigated them by molecular dynamics simulation. Conformational dynamics of the simulated protein complexes revealed several interaction sites that mirrored the interactions identified in the CLMS findings. Together, we showcase a proof-of-principle CLMS study to identify novel interferon-induced signaling complexes and anticipate broader use of CLMS to identify novel protein interaction dynamics within the tumour microenvironment." @default.
- W4309046822 created "2022-11-21" @default.
- W4309046822 creator A5002833815 @default.
- W4309046822 creator A5017020905 @default.
- W4309046822 creator A5019953619 @default.
- W4309046822 creator A5020550968 @default.
- W4309046822 creator A5020604432 @default.
- W4309046822 creator A5021077418 @default.
- W4309046822 creator A5033086342 @default.
- W4309046822 creator A5040400011 @default.
- W4309046822 creator A5053422355 @default.
- W4309046822 creator A5069004187 @default.
- W4309046822 creator A5081342927 @default.
- W4309046822 creator A5082767643 @default.
- W4309046822 creator A5087684273 @default.
- W4309046822 creator A5087875575 @default.
- W4309046822 date "2022-11-12" @default.
- W4309046822 modified "2023-09-30" @default.
- W4309046822 title "Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach" @default.
- W4309046822 cites W1503339982 @default.
- W4309046822 cites W1665929589 @default.
- W4309046822 cites W1953974801 @default.
- W4309046822 cites W1966078827 @default.
- W4309046822 cites W1972683642 @default.
- W4309046822 cites W1974667981 @default.
- W4309046822 cites W1985723042 @default.
- W4309046822 cites W1996130117 @default.
- W4309046822 cites W2015115860 @default.
- W4309046822 cites W2029475032 @default.
- W4309046822 cites W2029667189 @default.
- W4309046822 cites W2030739472 @default.
- W4309046822 cites W2031423498 @default.
- W4309046822 cites W2031913105 @default.
- W4309046822 cites W2032780125 @default.
- W4309046822 cites W2037199116 @default.
- W4309046822 cites W2040370905 @default.
- W4309046822 cites W2040783956 @default.
- W4309046822 cites W2052982889 @default.
- W4309046822 cites W2053455848 @default.
- W4309046822 cites W2058206747 @default.
- W4309046822 cites W2073621589 @default.
- W4309046822 cites W2078646756 @default.
- W4309046822 cites W2078844752 @default.
- W4309046822 cites W2100802864 @default.
- W4309046822 cites W2101505589 @default.
- W4309046822 cites W2102241905 @default.
- W4309046822 cites W2117521220 @default.
- W4309046822 cites W2119014922 @default.
- W4309046822 cites W2125887563 @default.
- W4309046822 cites W2128402485 @default.
- W4309046822 cites W2128702837 @default.
- W4309046822 cites W2132262459 @default.
- W4309046822 cites W2133402546 @default.
- W4309046822 cites W2136563039 @default.
- W4309046822 cites W2144206275 @default.
- W4309046822 cites W2151553287 @default.
- W4309046822 cites W2154164244 @default.
- W4309046822 cites W2158682956 @default.
- W4309046822 cites W2161818718 @default.
- W4309046822 cites W2169947232 @default.
- W4309046822 cites W2170776626 @default.
- W4309046822 cites W2263177460 @default.
- W4309046822 cites W2339763143 @default.
- W4309046822 cites W2410908789 @default.
- W4309046822 cites W2411300644 @default.
- W4309046822 cites W2487259150 @default.
- W4309046822 cites W2547803093 @default.
- W4309046822 cites W2586938873 @default.
- W4309046822 cites W2587027025 @default.
- W4309046822 cites W2782257977 @default.
- W4309046822 cites W2787693452 @default.
- W4309046822 cites W2895297687 @default.
- W4309046822 cites W2897056819 @default.
- W4309046822 cites W2897198327 @default.
- W4309046822 cites W2901258541 @default.
- W4309046822 cites W2904364223 @default.
- W4309046822 cites W2904658243 @default.
- W4309046822 cites W2918861759 @default.
- W4309046822 cites W2923177995 @default.
- W4309046822 cites W2927006335 @default.
- W4309046822 cites W3014819468 @default.
- W4309046822 cites W3018993583 @default.
- W4309046822 cites W3027960481 @default.
- W4309046822 cites W3039384063 @default.
- W4309046822 cites W3095583226 @default.
- W4309046822 cites W3095810975 @default.
- W4309046822 cites W3136259027 @default.
- W4309046822 cites W3157357317 @default.
- W4309046822 cites W3158276499 @default.
- W4309046822 cites W3164665275 @default.
- W4309046822 cites W3198585296 @default.
- W4309046822 cites W3211795435 @default.
- W4309046822 doi "https://doi.org/10.1038/s41598-022-21393-z" @default.
- W4309046822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36371414" @default.
- W4309046822 hasPublicationYear "2022" @default.
- W4309046822 type Work @default.
- W4309046822 citedByCount "1" @default.
- W4309046822 countsByYear W43090468222023 @default.
- W4309046822 crossrefType "journal-article" @default.
- W4309046822 hasAuthorship W4309046822A5002833815 @default.