Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309046853> ?p ?o ?g. }
- W4309046853 abstract "Mechanosensitive channels of small conductance, found in many living organisms, open under elevated membrane tension and thus play crucial roles in biological response to mechanical stress. Amongst these channels, MscK is unique in that its activation also requires external potassium ions. To better understand this dual gating mechanism by force and ligand, we elucidate distinct structures of MscK along the gating cycle using cryo-electron microscopy. The heptameric channel comprises three layers: a cytoplasmic domain, a periplasmic gating ring, and a markedly curved transmembrane domain that flattens and expands upon channel opening, which is accompanied by dilation of the periplasmic ring. Furthermore, our results support a potentially unifying mechanotransduction mechanism in ion channels depicted as flattening and expansion of the transmembrane domain." @default.
- W4309046853 created "2022-11-21" @default.
- W4309046853 creator A5040603919 @default.
- W4309046853 creator A5046422599 @default.
- W4309046853 creator A5046789026 @default.
- W4309046853 creator A5056791108 @default.
- W4309046853 creator A5091542086 @default.
- W4309046853 date "2022-11-12" @default.
- W4309046853 modified "2023-10-14" @default.
- W4309046853 title "Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel" @default.
- W4309046853 cites W1622986665 @default.
- W4309046853 cites W174923884 @default.
- W4309046853 cites W1820162764 @default.
- W4309046853 cites W1967597269 @default.
- W4309046853 cites W1982193382 @default.
- W4309046853 cites W1999467960 @default.
- W4309046853 cites W2005311358 @default.
- W4309046853 cites W2005557006 @default.
- W4309046853 cites W2006904414 @default.
- W4309046853 cites W2007168806 @default.
- W4309046853 cites W2014573882 @default.
- W4309046853 cites W2014895510 @default.
- W4309046853 cites W2024012749 @default.
- W4309046853 cites W2033451549 @default.
- W4309046853 cites W2036145275 @default.
- W4309046853 cites W2048009063 @default.
- W4309046853 cites W2056248793 @default.
- W4309046853 cites W2083517980 @default.
- W4309046853 cites W2086354121 @default.
- W4309046853 cites W2090973569 @default.
- W4309046853 cites W2112956889 @default.
- W4309046853 cites W2124026197 @default.
- W4309046853 cites W2130269636 @default.
- W4309046853 cites W2139358212 @default.
- W4309046853 cites W2147577454 @default.
- W4309046853 cites W2147869016 @default.
- W4309046853 cites W2154714625 @default.
- W4309046853 cites W2159958561 @default.
- W4309046853 cites W2161200201 @default.
- W4309046853 cites W2167605506 @default.
- W4309046853 cites W2169859711 @default.
- W4309046853 cites W2170500849 @default.
- W4309046853 cites W2176614647 @default.
- W4309046853 cites W2178135303 @default.
- W4309046853 cites W2179432713 @default.
- W4309046853 cites W2180229411 @default.
- W4309046853 cites W2464564128 @default.
- W4309046853 cites W2516840689 @default.
- W4309046853 cites W2587625522 @default.
- W4309046853 cites W2760821868 @default.
- W4309046853 cites W2774142732 @default.
- W4309046853 cites W2779962245 @default.
- W4309046853 cites W2785150634 @default.
- W4309046853 cites W2890548660 @default.
- W4309046853 cites W2903534151 @default.
- W4309046853 cites W2953625349 @default.
- W4309046853 cites W2969725318 @default.
- W4309046853 cites W2996862388 @default.
- W4309046853 cites W3014163245 @default.
- W4309046853 cites W3044636025 @default.
- W4309046853 cites W3083406432 @default.
- W4309046853 cites W3108495343 @default.
- W4309046853 cites W3109143003 @default.
- W4309046853 cites W3127174478 @default.
- W4309046853 cites W3131760520 @default.
- W4309046853 cites W3135911884 @default.
- W4309046853 cites W3177828909 @default.
- W4309046853 cites W3182767159 @default.
- W4309046853 cites W3193177455 @default.
- W4309046853 cites W4224012209 @default.
- W4309046853 cites W4232393194 @default.
- W4309046853 cites W4253695859 @default.
- W4309046853 cites W4255264873 @default.
- W4309046853 doi "https://doi.org/10.1038/s41467-022-34737-0" @default.
- W4309046853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36371466" @default.
- W4309046853 hasPublicationYear "2022" @default.
- W4309046853 type Work @default.
- W4309046853 citedByCount "4" @default.
- W4309046853 countsByYear W43090468532023 @default.
- W4309046853 crossrefType "journal-article" @default.
- W4309046853 hasAuthorship W4309046853A5040603919 @default.
- W4309046853 hasAuthorship W4309046853A5046422599 @default.
- W4309046853 hasAuthorship W4309046853A5046789026 @default.
- W4309046853 hasAuthorship W4309046853A5056791108 @default.
- W4309046853 hasAuthorship W4309046853A5091542086 @default.
- W4309046853 hasBestOaLocation W43090468531 @default.
- W4309046853 hasConcept C104317684 @default.
- W4309046853 hasConcept C118892022 @default.
- W4309046853 hasConcept C12554922 @default.
- W4309046853 hasConcept C170493617 @default.
- W4309046853 hasConcept C181104049 @default.
- W4309046853 hasConcept C185592680 @default.
- W4309046853 hasConcept C190062978 @default.
- W4309046853 hasConcept C194544171 @default.
- W4309046853 hasConcept C201663137 @default.
- W4309046853 hasConcept C24530287 @default.
- W4309046853 hasConcept C4001165 @default.
- W4309046853 hasConcept C41625074 @default.
- W4309046853 hasConcept C50254741 @default.
- W4309046853 hasConcept C53465041 @default.