FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309047237> ?p ?o ?g. }

• W4309047237 endingPage "109524" @default.
• W4309047237 startingPage "109524" @default.
• W4309047237 abstract "Hirschsprung's disease (HD) is widely characterized by the absence of ganglion cells in the colon of infants and children resulting in a spectrum of diseases starting from constipation to intestinal obstruction. The disease can have a serious manifestation of Hirschsprung-associated enterocolitis which can lead to significant morbidity and even mortality. Presently the treatment includes surgical excision of the pathological segment of the colon. Identification of the segment requires histopathology and immunohistochemistry which is time-consuming and requires significant expertise of a pathologist. There is a gap in the management of the disease in the form of absence of suitable, sensitive, and efficient technologies to detect the pathological segment of the intestine, which could significantly reduce surgery duration in the operation theatre, as well as associated risks to patients. It, therefore, becomes a matter of extreme importance to develop a point-of-care platform for early and efficient identification of the occurrence of HD in neonates and older children during surgery. The present work reports on the development of an electrochemical enzymatic biosensor using anodized laser-induced graphene (aLIG) conjugated with acetylcholinesterase enzyme (AchE), for detection of HD as a function of acetylcholine – the key biomarker. The developed sensor was initially characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), while the sensor's analytical performance was assessed using CV. The sensor exhibited a limit of detection of 0.26 μM with a shelf life of 1 month, while remaining unperturbed in the presence of common interferants. The performance of the developed sensor was also examined in spiked serum samples and was observed to yield a high degree of linearity." @default.
• W4309047237 created "2022-11-21" @default.
• W4309047237 creator A5004185658 @default.
• W4309047237 creator A5005827170 @default.
• W4309047237 creator A5018576736 @default.
• W4309047237 creator A5019883065 @default.
• W4309047237 creator A5065261371 @default.
• W4309047237 date "2022-12-01" @default.
• W4309047237 modified "2023-09-30" @default.
• W4309047237 title "Design and development of an electroanalytical enzymatic sensor using anodized laser induced graphene for the management of Hirschsprung Disease" @default.
• W4309047237 cites W1634643886 @default.
• W4309047237 cites W1964031845 @default.
• W4309047237 cites W1964396660 @default.
• W4309047237 cites W1978181806 @default.
• W4309047237 cites W1978236157 @default.
• W4309047237 cites W1981537845 @default.
• W4309047237 cites W1999195208 @default.
• W4309047237 cites W2023298254 @default.
• W4309047237 cites W2036101544 @default.
• W4309047237 cites W2060775586 @default.
• W4309047237 cites W2101772940 @default.
• W4309047237 cites W2120890726 @default.
• W4309047237 cites W2333023959 @default.
• W4309047237 cites W2415469665 @default.
• W4309047237 cites W2463471113 @default.
• W4309047237 cites W2507186467 @default.
• W4309047237 cites W2600084354 @default.
• W4309047237 cites W2615936487 @default.
• W4309047237 cites W2621736863 @default.
• W4309047237 cites W2767546068 @default.
• W4309047237 cites W2768003536 @default.
• W4309047237 cites W2886486436 @default.
• W4309047237 cites W2889942653 @default.
• W4309047237 cites W2923923924 @default.
• W4309047237 cites W2978494669 @default.
• W4309047237 cites W2979483023 @default.
• W4309047237 cites W2991754063 @default.
• W4309047237 cites W3005767077 @default.
• W4309047237 cites W3011716238 @default.
• W4309047237 cites W3019042088 @default.
• W4309047237 cites W3025592436 @default.
• W4309047237 cites W3026239964 @default.
• W4309047237 cites W3102697520 @default.
• W4309047237 cites W3118434670 @default.
• W4309047237 cites W3152573503 @default.
• W4309047237 doi "https://doi.org/10.1016/j.diamond.2022.109524" @default.
• W4309047237 hasPublicationYear "2022" @default.
• W4309047237 type Work @default.
• W4309047237 citedByCount "0" @default.
• W4309047237 crossrefType "journal-article" @default.
• W4309047237 hasAuthorship W4309047237A5004185658 @default.
• W4309047237 hasAuthorship W4309047237A5005827170 @default.
• W4309047237 hasAuthorship W4309047237A5018576736 @default.
• W4309047237 hasAuthorship W4309047237A5019883065 @default.
• W4309047237 hasAuthorship W4309047237A5065261371 @default.
• W4309047237 hasConcept C126322002 @default.
• W4309047237 hasConcept C136229726 @default.
• W4309047237 hasConcept C147789679 @default.
• W4309047237 hasConcept C171250308 @default.
• W4309047237 hasConcept C17525397 @default.
• W4309047237 hasConcept C185592680 @default.
• W4309047237 hasConcept C192562407 @default.
• W4309047237 hasConcept C2781197716 @default.
• W4309047237 hasConcept C30080830 @default.
• W4309047237 hasConcept C52859227 @default.
• W4309047237 hasConcept C55493867 @default.
• W4309047237 hasConcept C7040849 @default.
• W4309047237 hasConcept C71924100 @default.
• W4309047237 hasConceptScore W4309047237C126322002 @default.
• W4309047237 hasConceptScore W4309047237C136229726 @default.
• W4309047237 hasConceptScore W4309047237C147789679 @default.
• W4309047237 hasConceptScore W4309047237C171250308 @default.
• W4309047237 hasConceptScore W4309047237C17525397 @default.
• W4309047237 hasConceptScore W4309047237C185592680 @default.
• W4309047237 hasConceptScore W4309047237C192562407 @default.
• W4309047237 hasConceptScore W4309047237C2781197716 @default.
• W4309047237 hasConceptScore W4309047237C30080830 @default.
• W4309047237 hasConceptScore W4309047237C52859227 @default.
• W4309047237 hasConceptScore W4309047237C55493867 @default.
• W4309047237 hasConceptScore W4309047237C7040849 @default.
• W4309047237 hasConceptScore W4309047237C71924100 @default.
• W4309047237 hasFunder F4320336200 @default.
• W4309047237 hasLocation W43090472371 @default.
• W4309047237 hasOpenAccess W4309047237 @default.
• W4309047237 hasPrimaryLocation W43090472371 @default.
• W4309047237 hasRelatedWork W2134948224 @default.
• W4309047237 hasRelatedWork W2137163290 @default.
• W4309047237 hasRelatedWork W2570068767 @default.
• W4309047237 hasRelatedWork W2758458810 @default.
• W4309047237 hasRelatedWork W2769077900 @default.
• W4309047237 hasRelatedWork W2896640114 @default.
• W4309047237 hasRelatedWork W2899084033 @default.
• W4309047237 hasRelatedWork W2957361663 @default.
• W4309047237 hasRelatedWork W3011755386 @default.
• W4309047237 hasRelatedWork W3111609763 @default.
• W4309047237 hasVolume "130" @default.
• W4309047237 isParatext "false" @default.
• W4309047237 isRetracted "false" @default.

• next