Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309048321> ?p ?o ?g. }
- W4309048321 endingPage "445" @default.
- W4309048321 startingPage "436" @default.
- W4309048321 abstract "The therapeutic landscape of patients with breast cancer has changed significantly with the introduction of antibody-drug conjugates (ADCs). Although human epidermal growth factor receptor 2 (HER2) has been the centerpiece of ADC development, potentially any surface antigen with differential expression between tumor and normal cells may be suitable for targeting with ADCs. Exploration of new targets is critical to expand the fraction of patients who can benefit from ADCs. Sacituzumab govitecan, an anti-trophoblast cell surface antigen 2 ADC, is the only non-anti-HER2 ADC approved for breast cancer to date, with several novel ADCs directed against novel targets (e.g., HER3, LIV-1) at various stages of preclinical and clinical development. The aim of this review is to provide an overview of clinical trials investigating ADCs targeting novel antigens. We discuss the optimal characteristics of the target to be exploited in ADCs' design and potential future challenges in the evolving field of ADCs such as biomarker assessment, patient selection, and sequencing of ADCs." @default.
- W4309048321 created "2022-11-21" @default.
- W4309048321 creator A5003897511 @default.
- W4309048321 creator A5017374197 @default.
- W4309048321 creator A5065064948 @default.
- W4309048321 creator A5069049140 @default.
- W4309048321 creator A5081854007 @default.
- W4309048321 date "2022-11-01" @default.
- W4309048321 modified "2023-10-09" @default.
- W4309048321 title "Antibody-Drug Conjugates in Breast Cancer: What Is Beyond HER2?" @default.
- W4309048321 cites W1486001319 @default.
- W4309048321 cites W1975898060 @default.
- W4309048321 cites W1985566789 @default.
- W4309048321 cites W1990601892 @default.
- W4309048321 cites W2009031388 @default.
- W4309048321 cites W2010662888 @default.
- W4309048321 cites W2095911832 @default.
- W4309048321 cites W2097914739 @default.
- W4309048321 cites W2104024752 @default.
- W4309048321 cites W2112853929 @default.
- W4309048321 cites W2113735973 @default.
- W4309048321 cites W2118102300 @default.
- W4309048321 cites W2138095640 @default.
- W4309048321 cites W2139802796 @default.
- W4309048321 cites W2141731867 @default.
- W4309048321 cites W2152163220 @default.
- W4309048321 cites W2153769134 @default.
- W4309048321 cites W2159967578 @default.
- W4309048321 cites W2170574224 @default.
- W4309048321 cites W2196945941 @default.
- W4309048321 cites W2233888390 @default.
- W4309048321 cites W2314772071 @default.
- W4309048321 cites W2531217210 @default.
- W4309048321 cites W2555391732 @default.
- W4309048321 cites W2597045666 @default.
- W4309048321 cites W2616923195 @default.
- W4309048321 cites W2621871296 @default.
- W4309048321 cites W2760931533 @default.
- W4309048321 cites W2790194326 @default.
- W4309048321 cites W2793831611 @default.
- W4309048321 cites W2912488281 @default.
- W4309048321 cites W2913291709 @default.
- W4309048321 cites W2916220774 @default.
- W4309048321 cites W2917403028 @default.
- W4309048321 cites W2953684910 @default.
- W4309048321 cites W2970626931 @default.
- W4309048321 cites W2970782214 @default.
- W4309048321 cites W2978260261 @default.
- W4309048321 cites W2996630100 @default.
- W4309048321 cites W3013223671 @default.
- W4309048321 cites W3042224347 @default.
- W4309048321 cites W3086278271 @default.
- W4309048321 cites W3088059925 @default.
- W4309048321 cites W3123935228 @default.
- W4309048321 cites W3128485166 @default.
- W4309048321 cites W3130820437 @default.
- W4309048321 cites W3130879882 @default.
- W4309048321 cites W3131293147 @default.
- W4309048321 cites W3132982007 @default.
- W4309048321 cites W3148626437 @default.
- W4309048321 cites W3156985612 @default.
- W4309048321 cites W3159552494 @default.
- W4309048321 cites W3161117856 @default.
- W4309048321 cites W3169973594 @default.
- W4309048321 cites W3172514414 @default.
- W4309048321 cites W3196246553 @default.
- W4309048321 cites W3205002341 @default.
- W4309048321 cites W4205795557 @default.
- W4309048321 cites W4220884574 @default.
- W4309048321 cites W4223962346 @default.
- W4309048321 cites W4226051140 @default.
- W4309048321 cites W4226097966 @default.
- W4309048321 cites W4281629035 @default.
- W4309048321 cites W4281635388 @default.
- W4309048321 cites W4281640394 @default.
- W4309048321 cites W4281664688 @default.
- W4309048321 cites W4281824652 @default.
- W4309048321 cites W4289916338 @default.
- W4309048321 doi "https://doi.org/10.1097/ppo.0000000000000629" @default.
- W4309048321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36383906" @default.
- W4309048321 hasPublicationYear "2022" @default.
- W4309048321 type Work @default.
- W4309048321 citedByCount "3" @default.
- W4309048321 countsByYear W43090483212023 @default.
- W4309048321 crossrefType "journal-article" @default.
- W4309048321 hasAuthorship W4309048321A5003897511 @default.
- W4309048321 hasAuthorship W4309048321A5017374197 @default.
- W4309048321 hasAuthorship W4309048321A5065064948 @default.
- W4309048321 hasAuthorship W4309048321A5069049140 @default.
- W4309048321 hasAuthorship W4309048321A5081854007 @default.
- W4309048321 hasConcept C121608353 @default.
- W4309048321 hasConcept C126322002 @default.
- W4309048321 hasConcept C143998085 @default.
- W4309048321 hasConcept C147483822 @default.
- W4309048321 hasConcept C159654299 @default.
- W4309048321 hasConcept C203014093 @default.
- W4309048321 hasConcept C2777325958 @default.
- W4309048321 hasConcept C2779438470 @default.