Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309067244> ?p ?o ?g. }
- W4309067244 abstract "Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in animal models of pathological pain. The actions of SPMs in acute and chronic itch are currently unknown. Recently, n-3 docosapentaenoic acid (DPA) was found to be a substrate for the biosynthesis of several novel families of SPMs and 3-oxa-PD1 n-3 DPA (3-oxa-PD1) is an oxidation-resistant metabolic stable analogue of the n-3 DPA-derived protectin D1 (PD1). In this article, we demonstrate that 3-oxa-PD1 effectively reduces both acute and chronic itch in mouse models. Intrathecal injection of 3-oxa-PD1 (100 ng) reduced acute itch induced by histamine, chloroquine, or morphine. Furthermore, intrathecal 3-oxa-PD1 effectively reduced chronic itch, induced by cutaneous T-cell lymphoma (CTCL), allergic contact dermatitis with dinitrofluorobenzene, and psoriasis by imiquimod. Intratumoral injection of 3-oxa-PD1 also suppressed CTCL-induced chronic itch. Strikingly, the antipruritic effect lasted for several weeks after 1-week intrathecal 3-oxa-PD1 treatment. Whole-cell recordings revealed significant increase in excitatory postsynaptic currents in spinal dorsal horn (SDH) neurons of CTCL mice, but this increase was blocked by 3-oxa-PD1. 3-oxa-PD1 further increased inhibitory postsynaptic currents in SDH neurons of CTCL mice. Cutaneous T-cell lymphoma increased the spinal levels of lipocalin-2 (LCN2), an itch mediator produced by astrocytes. 3-oxa-PD1 suppressed LCN2 production in CTCL mice and LCN2 secretion in astrocytes. Finally, CTCL-induced anxiety was alleviated by intrathecal 3-oxa-PD1. Our findings suggest that 3-oxa-PD1 potently inhibits acute and chronic itch through the regulation of excitatory or inhibitory synaptic transmission and astroglial LCN2 production. Therefore, stable SPM analogs such as 3-oxa-PD1 could be useful to treat pruritus associated with different skin injuries." @default.
- W4309067244 created "2022-11-21" @default.
- W4309067244 creator A5017163037 @default.
- W4309067244 creator A5029525374 @default.
- W4309067244 creator A5043761078 @default.
- W4309067244 creator A5064427328 @default.
- W4309067244 creator A5071546630 @default.
- W4309067244 creator A5090655358 @default.
- W4309067244 creator A5090993273 @default.
- W4309067244 date "2022-11-14" @default.
- W4309067244 modified "2023-09-23" @default.
- W4309067244 title "Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice" @default.
- W4309067244 cites W1490955806 @default.
- W4309067244 cites W1554222057 @default.
- W4309067244 cites W1556346244 @default.
- W4309067244 cites W1939997832 @default.
- W4309067244 cites W1951273690 @default.
- W4309067244 cites W1972780851 @default.
- W4309067244 cites W1982134608 @default.
- W4309067244 cites W1986892770 @default.
- W4309067244 cites W1988631520 @default.
- W4309067244 cites W1996634599 @default.
- W4309067244 cites W1997444760 @default.
- W4309067244 cites W1999682234 @default.
- W4309067244 cites W2004435536 @default.
- W4309067244 cites W2006767554 @default.
- W4309067244 cites W2015386261 @default.
- W4309067244 cites W2016087509 @default.
- W4309067244 cites W2024604676 @default.
- W4309067244 cites W2026535795 @default.
- W4309067244 cites W2030691041 @default.
- W4309067244 cites W2034102455 @default.
- W4309067244 cites W2051521434 @default.
- W4309067244 cites W2054124635 @default.
- W4309067244 cites W2059635921 @default.
- W4309067244 cites W2067182358 @default.
- W4309067244 cites W2067637071 @default.
- W4309067244 cites W2071289799 @default.
- W4309067244 cites W2072653944 @default.
- W4309067244 cites W2087004322 @default.
- W4309067244 cites W2090609282 @default.
- W4309067244 cites W2090722957 @default.
- W4309067244 cites W2096194006 @default.
- W4309067244 cites W2098799628 @default.
- W4309067244 cites W2109117252 @default.
- W4309067244 cites W2109879418 @default.
- W4309067244 cites W2117032899 @default.
- W4309067244 cites W2127493032 @default.
- W4309067244 cites W2128598867 @default.
- W4309067244 cites W2140005742 @default.
- W4309067244 cites W2146246868 @default.
- W4309067244 cites W2155524482 @default.
- W4309067244 cites W2156416313 @default.
- W4309067244 cites W2157340973 @default.
- W4309067244 cites W2157856809 @default.
- W4309067244 cites W2162465757 @default.
- W4309067244 cites W2177655369 @default.
- W4309067244 cites W2210741139 @default.
- W4309067244 cites W2236135063 @default.
- W4309067244 cites W2319317277 @default.
- W4309067244 cites W2340209045 @default.
- W4309067244 cites W2571213178 @default.
- W4309067244 cites W2602822324 @default.
- W4309067244 cites W2604624763 @default.
- W4309067244 cites W2623278488 @default.
- W4309067244 cites W2623469171 @default.
- W4309067244 cites W2743463442 @default.
- W4309067244 cites W2776648429 @default.
- W4309067244 cites W2788787807 @default.
- W4309067244 cites W2799273224 @default.
- W4309067244 cites W2883299124 @default.
- W4309067244 cites W2883360817 @default.
- W4309067244 cites W2884081766 @default.
- W4309067244 cites W2885694181 @default.
- W4309067244 cites W2885712658 @default.
- W4309067244 cites W2888968681 @default.
- W4309067244 cites W2944749860 @default.
- W4309067244 cites W2972641132 @default.
- W4309067244 cites W2973492017 @default.
- W4309067244 cites W2981634215 @default.
- W4309067244 cites W2989967963 @default.
- W4309067244 cites W2991754557 @default.
- W4309067244 cites W3033050557 @default.
- W4309067244 cites W3042215461 @default.
- W4309067244 cites W3046521611 @default.
- W4309067244 cites W3080211491 @default.
- W4309067244 cites W3081081363 @default.
- W4309067244 cites W3082774434 @default.
- W4309067244 cites W3096151566 @default.
- W4309067244 cites W3114045972 @default.
- W4309067244 cites W3128292268 @default.
- W4309067244 cites W3135548236 @default.
- W4309067244 cites W3149206400 @default.
- W4309067244 cites W3207028907 @default.
- W4309067244 cites W3214465289 @default.
- W4309067244 cites W4200260252 @default.
- W4309067244 cites W4200591287 @default.
- W4309067244 cites W4220984451 @default.
- W4309067244 cites W4224289809 @default.
- W4309067244 cites W4229000673 @default.