Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309074407> ?p ?o ?g. }
- W4309074407 endingPage "317" @default.
- W4309074407 startingPage "310" @default.
- W4309074407 abstract "Natural products and their derivatives historically represent alternatives to conventional synthetic molecules for pharmacotherapy, ranging from cancer chemotherapeutics to cosmetic ingredients that exert anti-aging activities. Cellular senescence is considered a main driver of skin aging, yet natural products that target skin senescence in a specific manner are not thoroughly explored. Here, we performed a focused compound screen to identify natural products that exert anti-senescence effects. We found that Isatis tinctoria, woad extracts, displayed a senolytic effect on senescent human skin fibroblasts. Furthermore, treatment with woad extracts attenuated the expression of pro-inflammatory senescence-associated secretory phenotype (SASP), showing a senostatic activity. Intriguingly, woad extracts displayed only a marginal cytotoxic effect toward senescent human lung fibroblasts. Thus, our results reveal the potential activities of woad extracts for targeting skin senescence and suggest that woad extracts could be an attractive ingredient for cosmetics to prevent skin aging." @default.
- W4309074407 created "2022-11-21" @default.
- W4309074407 creator A5000519026 @default.
- W4309074407 creator A5001666589 @default.
- W4309074407 creator A5014130113 @default.
- W4309074407 creator A5055794885 @default.
- W4309074407 creator A5055966577 @default.
- W4309074407 creator A5079132836 @default.
- W4309074407 creator A5091385586 @default.
- W4309074407 date "2022-11-02" @default.
- W4309074407 modified "2023-09-26" @default.
- W4309074407 title "A focused natural compound screen reveals senolytic and senostatic effects of <i>Isatis tinctoria</i>" @default.
- W4309074407 cites W1033197108 @default.
- W4309074407 cites W1800944583 @default.
- W4309074407 cites W1910950086 @default.
- W4309074407 cites W1966803146 @default.
- W4309074407 cites W2010417927 @default.
- W4309074407 cites W2061765285 @default.
- W4309074407 cites W2115852450 @default.
- W4309074407 cites W2123454317 @default.
- W4309074407 cites W2126525177 @default.
- W4309074407 cites W2128807350 @default.
- W4309074407 cites W2140930678 @default.
- W4309074407 cites W2193792657 @default.
- W4309074407 cites W2210634983 @default.
- W4309074407 cites W2266290735 @default.
- W4309074407 cites W2342055991 @default.
- W4309074407 cites W2344541663 @default.
- W4309074407 cites W2605674430 @default.
- W4309074407 cites W2620914886 @default.
- W4309074407 cites W2653191228 @default.
- W4309074407 cites W2739438570 @default.
- W4309074407 cites W2768033029 @default.
- W4309074407 cites W2788548733 @default.
- W4309074407 cites W2788640168 @default.
- W4309074407 cites W2860743873 @default.
- W4309074407 cites W2908922892 @default.
- W4309074407 cites W2913976105 @default.
- W4309074407 cites W2918803269 @default.
- W4309074407 cites W2946521685 @default.
- W4309074407 cites W2988310131 @default.
- W4309074407 cites W2991705817 @default.
- W4309074407 cites W2996943768 @default.
- W4309074407 cites W2997403414 @default.
- W4309074407 cites W2999421965 @default.
- W4309074407 cites W3008488132 @default.
- W4309074407 cites W3010113588 @default.
- W4309074407 cites W3014179439 @default.
- W4309074407 cites W3036603151 @default.
- W4309074407 cites W3042236956 @default.
- W4309074407 cites W3048953874 @default.
- W4309074407 cites W3107344158 @default.
- W4309074407 cites W3119952098 @default.
- W4309074407 cites W3131649487 @default.
- W4309074407 cites W3149967641 @default.
- W4309074407 cites W3159538085 @default.
- W4309074407 cites W3173458376 @default.
- W4309074407 cites W3174662675 @default.
- W4309074407 cites W3184600740 @default.
- W4309074407 cites W3201635430 @default.
- W4309074407 cites W3215215441 @default.
- W4309074407 cites W4200531511 @default.
- W4309074407 doi "https://doi.org/10.1080/19768354.2022.2143895" @default.
- W4309074407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36605596" @default.
- W4309074407 hasPublicationYear "2022" @default.
- W4309074407 type Work @default.
- W4309074407 citedByCount "2" @default.
- W4309074407 countsByYear W43090744072023 @default.
- W4309074407 crossrefType "journal-article" @default.
- W4309074407 hasAuthorship W4309074407A5000519026 @default.
- W4309074407 hasAuthorship W4309074407A5001666589 @default.
- W4309074407 hasAuthorship W4309074407A5014130113 @default.
- W4309074407 hasAuthorship W4309074407A5055794885 @default.
- W4309074407 hasAuthorship W4309074407A5055966577 @default.
- W4309074407 hasAuthorship W4309074407A5079132836 @default.
- W4309074407 hasAuthorship W4309074407A5091385586 @default.
- W4309074407 hasBestOaLocation W43090744071 @default.
- W4309074407 hasConcept C104317684 @default.
- W4309074407 hasConcept C127716648 @default.
- W4309074407 hasConcept C16005928 @default.
- W4309074407 hasConcept C2909910311 @default.
- W4309074407 hasConcept C522857546 @default.
- W4309074407 hasConcept C55493867 @default.
- W4309074407 hasConcept C71924100 @default.
- W4309074407 hasConcept C86803240 @default.
- W4309074407 hasConcept C95444343 @default.
- W4309074407 hasConcept C98274493 @default.
- W4309074407 hasConceptScore W4309074407C104317684 @default.
- W4309074407 hasConceptScore W4309074407C127716648 @default.
- W4309074407 hasConceptScore W4309074407C16005928 @default.
- W4309074407 hasConceptScore W4309074407C2909910311 @default.
- W4309074407 hasConceptScore W4309074407C522857546 @default.
- W4309074407 hasConceptScore W4309074407C55493867 @default.
- W4309074407 hasConceptScore W4309074407C71924100 @default.
- W4309074407 hasConceptScore W4309074407C86803240 @default.
- W4309074407 hasConceptScore W4309074407C95444343 @default.
- W4309074407 hasConceptScore W4309074407C98274493 @default.
- W4309074407 hasFunder F4320322120 @default.