Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309076165> ?p ?o ?g. }
- W4309076165 abstract "Abstract LRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how LRRK2 mutations altered striatal physiology. While we found that both R1441C and G2019S mice displayed reduced nigrostriatal dopamine release, hypoexcitability in indirect-pathway striatal projection neurons, and alterations associated with an impaired striatal-dependent motor learning were observed only in the R1441C mice. We also showed that increased synaptic PKA activities in the R1441C and not G2019S mice underlie the specific alterations in motor learning deficits in the R1441C mice. In summary, our data argue that LRRK2 mutations’ impact on the striatum cannot be simply generalized. Instead, alterations in electrochemical, electrophysiological, molecular, and behavioral levels were distinct between LRRK2 mutations. Our findings offer mechanistic insights for devising and optimizing treatment strategies for PD patients." @default.
- W4309076165 created "2022-11-21" @default.
- W4309076165 creator A5006091776 @default.
- W4309076165 creator A5015371539 @default.
- W4309076165 creator A5034702634 @default.
- W4309076165 creator A5037843732 @default.
- W4309076165 creator A5064586683 @default.
- W4309076165 creator A5065174544 @default.
- W4309076165 creator A5066027781 @default.
- W4309076165 creator A5069359376 @default.
- W4309076165 creator A5073371993 @default.
- W4309076165 creator A5091387951 @default.
- W4309076165 date "2022-11-10" @default.
- W4309076165 modified "2023-09-30" @default.
- W4309076165 title "R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations" @default.
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