Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309076183> ?p ?o ?g. }
- W4309076183 abstract "Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic mechanisms. Here we report an exceptionally large and evolutionarily conserved protein LPD-3 in C. elegans that mediates lipid trafficking to confer cold resilience. We identify lpd-3 mutants in a mutagenesis screen for genetic suppressors of the lipid desaturase FAT-7. LPD-3 bridges the endoplasmic reticulum (ER) and plasma membranes (PM), forming a structurally predicted hydrophobic tunnel for lipid trafficking. lpd-3 mutants exhibit abnormal phospholipid distribution, diminished FAT-7 abundance, organismic vulnerability to cold, and are rescued by Lecithin comprising unsaturated phospholipids. Deficient lpd-3 homologues in Zebrafish and mammalian cells cause defects similar to those observed in C. elegans. As mutations in BLTP1, the human orthologue of lpd-3, cause Alkuraya-Kucinskas syndrome, LPD-3 family proteins may serve as evolutionarily conserved highway bridges critical for ER-associated non-vesicular lipid trafficking and resilience to cold stress in eukaryotic cells." @default.
- W4309076183 created "2022-11-21" @default.
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- W4309076183 date "2022-11-10" @default.
- W4309076183 modified "2023-10-03" @default.
- W4309076183 title "A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience" @default.
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- W4309076183 doi "https://doi.org/10.1038/s41467-022-34450-y" @default.
- W4309076183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36357390" @default.
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