Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309076306> ?p ?o ?g. }
- W4309076306 abstract "Abstract Lumpy skin disease (LSD) is a transboundary viral disease of cattle that causes substantial economic loss globally. There is no specific treatment and subunit vaccine for this disease to date. Reports of the global spread of this disease are worrisome. We designed a multi-epitope protein using an immunoinformatics approach in this study. We analyzed the proteome of LSDV and found 32 structural/surface proteins. Four of these 32 proteins were predicted as antigenic and non-homologous to bovine and highly conserved in 26 LSDV isolates. The predicted B-cell epitopes and CTL epitopes were stitched together with the help of an AAY linker leading to the formation of a multi-epitope protein. The in silico study revealed that the modeled subunit vaccine candidate and TLR4 receptor interact with high affinity. This interaction was also found to be stable using a molecular dynamics simulation study. Our study demonstrates a leap towards developing a subunit vaccine against LSD." @default.
- W4309076306 created "2022-11-21" @default.
- W4309076306 creator A5018803536 @default.
- W4309076306 creator A5053710272 @default.
- W4309076306 creator A5058555331 @default.
- W4309076306 creator A5074868247 @default.
- W4309076306 date "2022-11-12" @default.
- W4309076306 modified "2023-10-18" @default.
- W4309076306 title "Design of a multi-epitope protein as a subunit vaccine against lumpy skin disease using an immunoinformatics approach" @default.
- W4309076306 cites W1483162601 @default.
- W4309076306 cites W1499978168 @default.
- W4309076306 cites W1607931568 @default.
- W4309076306 cites W1887624773 @default.
- W4309076306 cites W1981264193 @default.
- W4309076306 cites W1986191025 @default.
- W4309076306 cites W1995866508 @default.
- W4309076306 cites W2005014362 @default.
- W4309076306 cites W2011850230 @default.
- W4309076306 cites W2012226492 @default.
- W4309076306 cites W2012625502 @default.
- W4309076306 cites W2014274241 @default.
- W4309076306 cites W2017946420 @default.
- W4309076306 cites W2032966566 @default.
- W4309076306 cites W2035014358 @default.
- W4309076306 cites W2052046406 @default.
- W4309076306 cites W2055043387 @default.
- W4309076306 cites W2056525120 @default.
- W4309076306 cites W2061096391 @default.
- W4309076306 cites W2076427028 @default.
- W4309076306 cites W2087663912 @default.
- W4309076306 cites W2102023232 @default.
- W4309076306 cites W2102367710 @default.
- W4309076306 cites W2113836667 @default.
- W4309076306 cites W2127322768 @default.
- W4309076306 cites W2131900949 @default.
- W4309076306 cites W2131965976 @default.
- W4309076306 cites W2133003848 @default.
- W4309076306 cites W2139915497 @default.
- W4309076306 cites W2140759397 @default.
- W4309076306 cites W2151460035 @default.
- W4309076306 cites W2151982298 @default.
- W4309076306 cites W2152770371 @default.
- W4309076306 cites W2165837267 @default.
- W4309076306 cites W2165869975 @default.
- W4309076306 cites W2170930106 @default.
- W4309076306 cites W2238899646 @default.
- W4309076306 cites W2283018908 @default.
- W4309076306 cites W2323889349 @default.
- W4309076306 cites W2397293145 @default.
- W4309076306 cites W2418729003 @default.
- W4309076306 cites W2572080171 @default.
- W4309076306 cites W2585451190 @default.
- W4309076306 cites W2752858517 @default.
- W4309076306 cites W2904817194 @default.
- W4309076306 cites W2933588544 @default.
- W4309076306 cites W2945172910 @default.
- W4309076306 cites W3007680806 @default.
- W4309076306 cites W3011853047 @default.
- W4309076306 cites W3017006167 @default.
- W4309076306 cites W3024849063 @default.
- W4309076306 cites W3028026747 @default.
- W4309076306 cites W3082464123 @default.
- W4309076306 cites W3171147556 @default.
- W4309076306 cites W3183508816 @default.
- W4309076306 cites W3202524175 @default.
- W4309076306 cites W4211196614 @default.
- W4309076306 cites W4250200907 @default.
- W4309076306 cites W4280538347 @default.
- W4309076306 cites W4281390237 @default.
- W4309076306 cites W4283313042 @default.
- W4309076306 cites W4285593338 @default.
- W4309076306 cites W4296698246 @default.
- W4309076306 doi "https://doi.org/10.1038/s41598-022-23272-z" @default.
- W4309076306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36371522" @default.
- W4309076306 hasPublicationYear "2022" @default.
- W4309076306 type Work @default.
- W4309076306 citedByCount "5" @default.
- W4309076306 countsByYear W43090763062023 @default.
- W4309076306 crossrefType "journal-article" @default.
- W4309076306 hasAuthorship W4309076306A5018803536 @default.
- W4309076306 hasAuthorship W4309076306A5053710272 @default.
- W4309076306 hasAuthorship W4309076306A5058555331 @default.
- W4309076306 hasAuthorship W4309076306A5074868247 @default.
- W4309076306 hasBestOaLocation W43090763061 @default.
- W4309076306 hasConcept C104292427 @default.
- W4309076306 hasConcept C104317684 @default.
- W4309076306 hasConcept C104397665 @default.
- W4309076306 hasConcept C147483822 @default.
- W4309076306 hasConcept C159047783 @default.
- W4309076306 hasConcept C195616568 @default.
- W4309076306 hasConcept C203014093 @default.
- W4309076306 hasConcept C2775905019 @default.
- W4309076306 hasConcept C2779026604 @default.
- W4309076306 hasConcept C2781241564 @default.
- W4309076306 hasConcept C54355233 @default.
- W4309076306 hasConcept C60644358 @default.
- W4309076306 hasConcept C70721500 @default.
- W4309076306 hasConcept C86803240 @default.
- W4309076306 hasConceptScore W4309076306C104292427 @default.
- W4309076306 hasConceptScore W4309076306C104317684 @default.