Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309077431> ?p ?o ?g. }
- W4309077431 endingPage "116189" @default.
- W4309077431 startingPage "116189" @default.
- W4309077431 abstract "In the present work, we report the synthesis, structural characterization and in vitro biological evaluation of four mononuclear Cu(II) and Co(II) complexes 1–4 derived from the Schiff base ligand scaffolds L1 and L2. The synthesized complexes 1–4 were systematically characterized by various analytical and spectroscopic techniques (FTIR, EPR, UV–vis and sXRD). DFT calculations were performed to determine the structural, electronic and chemical properties of complexes 1–4 based on their respective HOMO and LUMO energy values. Hirshfeld surface analysis was carried out to examine the intermolecular interactions (CH···O, NH···H, Cl–H···H and OH···O) which define the stability of the crystal lattice. Furthermore, comparative in vitro DNA/BSA binding studies were carried out by employing various biophysical methods which revealed a higher binding propensity for the copper analogues. The antioxidant activity of complexes 1–4 was also evaluated against the free radical DPPH and the results demonstrated a better radical scavenging activity by the copper analogues. In addition, the cytotoxicity of the complexes was evaluated using an SRB assay against MDA–MB–231/HCC1806 (triple negative breast cancer cell lines) and HT–29 (colorectal cancer cell lines), which revealed remarkable cytotoxicity of complex 3 against the tested cancer cell lines. The toxicity profile of the complexes was also evaluated against VERO (normal kidney epithelial) cells, which validated their low toxicity behaviour." @default.
- W4309077431 created "2022-11-21" @default.
- W4309077431 creator A5009713147 @default.
- W4309077431 creator A5010103995 @default.
- W4309077431 creator A5036623558 @default.
- W4309077431 creator A5084938854 @default.
- W4309077431 creator A5086339878 @default.
- W4309077431 date "2023-01-01" @default.
- W4309077431 modified "2023-09-28" @default.
- W4309077431 title "Synthesis, structural characterization and in vitro cytotoxicity assessment of new mononuclear Cu(II) and Co(II) complexes against MDA–MB–231, HCC–1806 and HT–29 cancer cell lines" @default.
- W4309077431 cites W1752386006 @default.
- W4309077431 cites W1819645169 @default.
- W4309077431 cites W1852168664 @default.
- W4309077431 cites W1876035649 @default.
- W4309077431 cites W1913218312 @default.
- W4309077431 cites W1958849729 @default.
- W4309077431 cites W1967747500 @default.
- W4309077431 cites W1968068945 @default.
- W4309077431 cites W1969360633 @default.
- W4309077431 cites W1971326367 @default.
- W4309077431 cites W1975569863 @default.
- W4309077431 cites W1977857020 @default.
- W4309077431 cites W1978525989 @default.
- W4309077431 cites W1984883623 @default.
- W4309077431 cites W1985862762 @default.
- W4309077431 cites W1988306316 @default.
- W4309077431 cites W1991468027 @default.
- W4309077431 cites W1992768525 @default.
- W4309077431 cites W1993127104 @default.
- W4309077431 cites W1998483039 @default.
- W4309077431 cites W1998722626 @default.
- W4309077431 cites W2001976945 @default.
- W4309077431 cites W2004112993 @default.
- W4309077431 cites W2008664172 @default.
- W4309077431 cites W2009629022 @default.
- W4309077431 cites W2012076508 @default.
- W4309077431 cites W2012488984 @default.
- W4309077431 cites W2012775604 @default.
- W4309077431 cites W2012949016 @default.
- W4309077431 cites W2014286678 @default.
- W4309077431 cites W2023303881 @default.
- W4309077431 cites W2024031891 @default.
- W4309077431 cites W2025938842 @default.
- W4309077431 cites W2027542963 @default.
- W4309077431 cites W2029302577 @default.
- W4309077431 cites W2031444953 @default.
- W4309077431 cites W2040184556 @default.
- W4309077431 cites W2040282501 @default.
- W4309077431 cites W2042675162 @default.
- W4309077431 cites W2043761202 @default.
- W4309077431 cites W2044851985 @default.
- W4309077431 cites W2047190819 @default.
- W4309077431 cites W2056767189 @default.
- W4309077431 cites W2059205366 @default.
- W4309077431 cites W2059828654 @default.
- W4309077431 cites W2059841792 @default.
- W4309077431 cites W2061942755 @default.
- W4309077431 cites W2063765458 @default.
- W4309077431 cites W2064954921 @default.
- W4309077431 cites W2068509261 @default.
- W4309077431 cites W2075644244 @default.
- W4309077431 cites W2078170455 @default.
- W4309077431 cites W2083421040 @default.
- W4309077431 cites W2083481849 @default.
- W4309077431 cites W2093084777 @default.
- W4309077431 cites W2095084300 @default.
- W4309077431 cites W2097607581 @default.
- W4309077431 cites W2098116644 @default.
- W4309077431 cites W2103186652 @default.
- W4309077431 cites W2104017463 @default.
- W4309077431 cites W2111194038 @default.
- W4309077431 cites W2111570380 @default.
- W4309077431 cites W2112253518 @default.
- W4309077431 cites W2115359039 @default.
- W4309077431 cites W2116177049 @default.
- W4309077431 cites W2127395941 @default.
- W4309077431 cites W2135732933 @default.
- W4309077431 cites W2142787097 @default.
- W4309077431 cites W2145288842 @default.
- W4309077431 cites W2151011742 @default.
- W4309077431 cites W2156103494 @default.
- W4309077431 cites W2158534713 @default.
- W4309077431 cites W2267090133 @default.
- W4309077431 cites W2293355308 @default.
- W4309077431 cites W2295221315 @default.
- W4309077431 cites W2312599638 @default.
- W4309077431 cites W2325878452 @default.
- W4309077431 cites W2328004268 @default.
- W4309077431 cites W2334138351 @default.
- W4309077431 cites W2344984955 @default.
- W4309077431 cites W2416444049 @default.
- W4309077431 cites W2510886209 @default.
- W4309077431 cites W2605275930 @default.
- W4309077431 cites W2616262604 @default.
- W4309077431 cites W2729886235 @default.
- W4309077431 cites W2735783084 @default.
- W4309077431 cites W2772202981 @default.
- W4309077431 cites W2773844754 @default.