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- W4309078429 abstract "A series of novel 1-(β-coumarinyl)-1-(β-indolyl)-1-(α-thiophenyl)trifluoroethane derivatives 5aaa-5hdb were prepared by one-pot reaction from 3-(trifluoroacetyl)coumarin with indole and α-substituted thiophene. Their structures were confirmed by 1H NMR, 13C NMR, 19F NMR, HRMS and X-ray single crystal diffraction, and their antifungal activities against F. moniliforme, F. graminearum, F. oxysporum, R. solani and P. nicotianae were evaluated. The title compounds displayed significant to moderate in vitro antifungal activity when compared to the standard drug triadimefon. Among the synthesized compounds, compound 5bfa showed the highest inhibitor rate of 83.5 % at 0.500 mg/mL against R. solani, while compound 5ada displayed the highest inhibitor rate of 73.3 % at 0.500 mg/mL against F. graminearum." @default.
- W4309078429 created "2022-11-21" @default.
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- W4309078429 date "2022-11-01" @default.
- W4309078429 modified "2023-10-14" @default.
- W4309078429 title "Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene" @default.
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- W4309078429 doi "https://doi.org/10.1016/j.jscs.2022.101572" @default.
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