FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309082068> ?p ?o ?g. }

• W4309082068 endingPage "114014" @default.
• W4309082068 startingPage "114014" @default.
• W4309082068 abstract "Liver fibrosis is the result of a chronic pathological condition caused by the activation of hepatic stellate cells (HSCs), which induces the excessive deposition of extracellular matrix. Fibrogenesis is sustained by an exaggerated production of reactive oxidative species (ROS) by NADPH oxidases (NOXs), which are overactivated in hepatic inflammation. In this study, we investigated the antifibrotic properties of two phenolic compounds of natural origin, tyrosol (Tyr) and hydroxytyrosol (HTyr), known for their antioxidant and anti-inflammatory effects. We assessed Tyr and HTyr antifibrotic and antioxidant activity both in vitro, by a co-culture of LX2, HepG2 and THP1-derived Mϕ macrophages, set up to simulate the hepatic microenvironment, and in vivo, in a mouse model of liver fibrosis obtained by carbon tetrachloride treatment. We evaluated the mRNA and protein expression of profibrotic and oxidative markers (α-SMA, COL1A1, NOX1/4) by qPCR and/or immunocytochemistry or immunohistochemistry. The expression of selected miRNAs in mouse livers were measured by qPCR. Tyr and HTyr reduces fibrogenesis in vitro and in vivo, by downregulating all fibrotic markers. Notably, they also modulated oxidative stress by restoring the physiological levels of NOX1 and NOX4. In vivo, this effect was accompanied by a transcriptional regulation of inflammatory genes and of 2 miRNAs involved in the control of oxidative stress damage (miR-181-5p and miR-29b-3p). In conclusion, Tyr and HTyr exert antifibrotic and anti-inflammatory effects in preclinical in vitro and in vivo models of liver fibrosis, by modulating hepatic oxidative stress, representing promising candidates for further development." @default.
• W4309082068 created "2022-11-21" @default.
• W4309082068 creator A5003787003 @default.
• W4309082068 creator A5009735264 @default.
• W4309082068 creator A5013014262 @default.
• W4309082068 creator A5015811681 @default.
• W4309082068 creator A5017874146 @default.
• W4309082068 creator A5027631947 @default.
• W4309082068 creator A5032501131 @default.
• W4309082068 creator A5043534278 @default.
• W4309082068 creator A5054179969 @default.
• W4309082068 creator A5054823471 @default.
• W4309082068 creator A5059921142 @default.
• W4309082068 creator A5060460268 @default.
• W4309082068 creator A5072629039 @default.
• W4309082068 creator A5073783997 @default.
• W4309082068 creator A5084241153 @default.
• W4309082068 date "2023-01-01" @default.
• W4309082068 modified "2023-09-29" @default.
• W4309082068 title "The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs" @default.
• W4309082068 cites W1428284454 @default.
• W4309082068 cites W1479958405 @default.
• W4309082068 cites W1490817952 @default.
• W4309082068 cites W1572116485 @default.
• W4309082068 cites W1895601060 @default.
• W4309082068 cites W1986904544 @default.
• W4309082068 cites W2005119615 @default.
• W4309082068 cites W2008713912 @default.
• W4309082068 cites W2009519656 @default.
• W4309082068 cites W2014750930 @default.
• W4309082068 cites W2019646105 @default.
• W4309082068 cites W2028658650 @default.
• W4309082068 cites W2055420649 @default.
• W4309082068 cites W2077006626 @default.
• W4309082068 cites W2082015270 @default.
• W4309082068 cites W2085128107 @default.
• W4309082068 cites W2097527455 @default.
• W4309082068 cites W2124841074 @default.
• W4309082068 cites W2127401224 @default.
• W4309082068 cites W2133728748 @default.
• W4309082068 cites W2149003918 @default.
• W4309082068 cites W2159375447 @default.
• W4309082068 cites W2162439940 @default.
• W4309082068 cites W2169794895 @default.
• W4309082068 cites W2171036151 @default.
• W4309082068 cites W2191264975 @default.
• W4309082068 cites W2237475067 @default.
• W4309082068 cites W2412566760 @default.
• W4309082068 cites W2419581469 @default.
• W4309082068 cites W2549229677 @default.
• W4309082068 cites W2559513130 @default.
• W4309082068 cites W2728826798 @default.
• W4309082068 cites W2767860182 @default.
• W4309082068 cites W2883704382 @default.
• W4309082068 cites W2893314247 @default.
• W4309082068 cites W2945470910 @default.
• W4309082068 cites W2970047903 @default.
• W4309082068 cites W2981172093 @default.
• W4309082068 cites W3000251936 @default.
• W4309082068 cites W3014599953 @default.
• W4309082068 cites W3041116897 @default.
• W4309082068 cites W3041419400 @default.
• W4309082068 cites W3093031605 @default.
• W4309082068 cites W3171175047 @default.
• W4309082068 cites W3171585054 @default.
• W4309082068 cites W3203643970 @default.
• W4309082068 cites W3206460155 @default.
• W4309082068 cites W4210722034 @default.
• W4309082068 cites W4225125073 @default.
• W4309082068 cites W4295926462 @default.
• W4309082068 doi "https://doi.org/10.1016/j.biopha.2022.114014" @default.
• W4309082068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36379119" @default.
• W4309082068 hasPublicationYear "2023" @default.
• W4309082068 type Work @default.
• W4309082068 citedByCount "5" @default.
• W4309082068 countsByYear W43090820682023 @default.
• W4309082068 crossrefType "journal-article" @default.
• W4309082068 hasAuthorship W4309082068A5003787003 @default.
• W4309082068 hasAuthorship W4309082068A5009735264 @default.
• W4309082068 hasAuthorship W4309082068A5013014262 @default.
• W4309082068 hasAuthorship W4309082068A5015811681 @default.
• W4309082068 hasAuthorship W4309082068A5017874146 @default.
• W4309082068 hasAuthorship W4309082068A5027631947 @default.
• W4309082068 hasAuthorship W4309082068A5032501131 @default.
• W4309082068 hasAuthorship W4309082068A5043534278 @default.
• W4309082068 hasAuthorship W4309082068A5054179969 @default.
• W4309082068 hasAuthorship W4309082068A5054823471 @default.
• W4309082068 hasAuthorship W4309082068A5059921142 @default.
• W4309082068 hasAuthorship W4309082068A5060460268 @default.
• W4309082068 hasAuthorship W4309082068A5072629039 @default.
• W4309082068 hasAuthorship W4309082068A5073783997 @default.
• W4309082068 hasAuthorship W4309082068A5084241153 @default.
• W4309082068 hasBestOaLocation W43090820681 @default.
• W4309082068 hasConcept C134018914 @default.
• W4309082068 hasConcept C142724271 @default.
• W4309082068 hasConcept C150903083 @default.
• W4309082068 hasConcept C176891718 @default.
• W4309082068 hasConcept C185592680 @default.

• next