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• W4309084294 abstract "Migraines are prevalent and cause significant morbidity, decline in quality of life and healthcare costs universally. Treatment options are varied, but efficacy is limited. This review centers on Eptinezumab-jjmr, a humanized monoclonal specific to CGRP for the prevention of migraines in adults. Herein presented are the science and mechanism of action, indication and clinical evidence for use.Migraines are severe, recurrent headaches, which are either episodic or chronic in nature. The pain is severe, often accompanied by co-morbid symptoms, such as photophobia, phonophobia, nausea and emesis, and is limiting in nature. It is a prevalent disorder that causes significant, worldwide disability, morbidity, suffering, and costs.The pathophysiology of migraines is actively studied, though recent research points to an initiating event causing migraine generation, that is then propagated by other brain regions, a significant one being the trigeminocervical complex. This is driven by biochemical transmitters, chiefly CGRP. This discovery led to the development of CGRP-targeting drugs, including gepants (small molecular antagonists) and anti-CGRP antibodies, such as Eptinezumab-jjmr.Traditional therapy includes preventative and abortive treatment; however, adherence with preventative treatment has been historically poor, and certain types of abortive therapy carry risks and side effects that preclude them from a large patient population. Moreover, traditional therapy often falls short in migraine therapy. CGRP antagonist, including Eptinezumab, aims to cover the gaps in migraine therapy. We present here evidence to support the safe and effective use of Eptinezumab for the prevention of migraines.Migraines are a prevalent primary headache disorder causing significant morbidity worldwide. Traditional abortive and preventative treatments fall short for many patients. Eptinezumab is part of new generation of CGRP-targeting medications and has shown significant evidence to support its use for the prevention of migraines. Further research is required to properly compare eptinezumab with existing pharmacotherapy and update guidelines on the appropriate combinations of therapies that are not available and the correct patient selection for each." @default.
• W4309084294 created "2022-11-21" @default.
• W4309084294 creator A5007416355 @default.
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• W4309084294 date "2022-11-12" @default.
• W4309084294 modified "2023-09-27" @default.
• W4309084294 title "Eptinezumab-jjmr, a humanized monoclonal specific to Calcitonin Gene Related Peptide, for the preventive treatment of migraine in adults" @default.
• W4309084294 cites W1892375736 @default.
• W4309084294 cites W1963591991 @default.
• W4309084294 cites W1988662090 @default.
• W4309084294 cites W1995699180 @default.
• W4309084294 cites W2025168050 @default.
• W4309084294 cites W2032593044 @default.
• W4309084294 cites W2040594661 @default.
• W4309084294 cites W2043730163 @default.
• W4309084294 cites W2047041272 @default.
• W4309084294 cites W2047700866 @default.
• W4309084294 cites W2051131416 @default.
• W4309084294 cites W2068748307 @default.
• W4309084294 cites W2074192427 @default.
• W4309084294 cites W2087030391 @default.
• W4309084294 cites W2108682124 @default.
• W4309084294 cites W2111548432 @default.
• W4309084294 cites W2114736324 @default.
• W4309084294 cites W2123954268 @default.
• W4309084294 cites W2124879125 @default.
• W4309084294 cites W2129181629 @default.
• W4309084294 cites W2148445312 @default.
• W4309084294 cites W2158846562 @default.
• W4309084294 cites W2162942726 @default.
• W4309084294 cites W2249320580 @default.
• W4309084294 cites W2399750252 @default.
• W4309084294 cites W2463900009 @default.
• W4309084294 cites W2586533881 @default.
• W4309084294 cites W2589422507 @default.
• W4309084294 cites W2602005220 @default.
• W4309084294 cites W2766131383 @default.
• W4309084294 cites W2771927282 @default.
• W4309084294 cites W2789321599 @default.
• W4309084294 cites W2795835597 @default.
• W4309084294 cites W2801341258 @default.
• W4309084294 cites W2802215006 @default.
• W4309084294 cites W2802590373 @default.
• W4309084294 cites W2805078797 @default.
• W4309084294 cites W2806908169 @default.
• W4309084294 cites W2853108461 @default.
• W4309084294 cites W2894749823 @default.
• W4309084294 cites W2895868360 @default.
• W4309084294 cites W2898072840 @default.
• W4309084294 cites W2898958234 @default.
• W4309084294 cites W2899821434 @default.
• W4309084294 cites W2914996465 @default.
• W4309084294 cites W2916643799 @default.
• W4309084294 cites W2920919248 @default.
• W4309084294 cites W2922174162 @default.
• W4309084294 cites W2936553526 @default.
• W4309084294 cites W2937672623 @default.
• W4309084294 cites W2944957936 @default.
• W4309084294 cites W2955283194 @default.
• W4309084294 cites W2970706487 @default.
• W4309084294 cites W2970814103 @default.
• W4309084294 cites W2976147368 @default.
• W4309084294 cites W2976414363 @default.
• W4309084294 cites W2980478286 @default.
• W4309084294 cites W2982306342 @default.
• W4309084294 cites W2994136002 @default.
• W4309084294 cites W3007053288 @default.
• W4309084294 cites W3010985439 @default.
• W4309084294 cites W3012537592 @default.
• W4309084294 cites W3012707125 @default.
• W4309084294 cites W3013251859 @default.
• W4309084294 cites W3013502865 @default.
• W4309084294 cites W3014143604 @default.
• W4309084294 cites W3014413975 @default.
• W4309084294 cites W3016474276 @default.
• W4309084294 cites W3021848323 @default.
• W4309084294 cites W3023532405 @default.
• W4309084294 cites W3088648641 @default.
• W4309084294 cites W3089430347 @default.
• W4309084294 cites W3091538692 @default.
• W4309084294 cites W3092275911 @default.
• W4309084294 cites W3107691911 @default.
• W4309084294 cites W3123838670 @default.
• W4309084294 cites W4211090737 @default.
• W4309084294 cites W4235330493 @default.
• W4309084294 cites W4237416948 @default.
• W4309084294 cites W4244732427 @default.
• W4309084294 cites W4244823958 @default.
• W4309084294 cites W4293170930 @default.
• W4309084294 doi "https://doi.org/10.52965/001c.38439" @default.
• W4309084294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36381178" @default.
• W4309084294 hasPublicationYear "2022" @default.
• W4309084294 type Work @default.

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