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- W4309091838 abstract "Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer, but it has nephrotoxic side effects leading to acute kidney injury and subsequently chronic kidney disease (CKD). Previous work has focused on acute kidney tubular injury induced by cisplatin, whereas the chronic sequelae post-injury has not been well-explored. In the present study, we established a kidney fibroblast model of CKD induced by repeated administration of cisplatin (RAC) as a clinically relevant model. In NRK-49F rat kidney fibroblasts, RAC upregulated α-smooth muscle actin (α-SMA) and fibronectin proteins, suggesting that RAC induces kidney fibroblast-to-myofibroblast transformation. RAC also enhanced cell size, including the cell attachment surface area, nuclear area, and cell volume. Furthermore, RAC induced p21 expression and senescence-associated β-galactosidase activity, suggesting that kidney fibroblasts exposed to RAC develop a senescent phenotype. Inhibition of p21 reduced cellular senescence, hypertrophy, and myofibroblast transformation induced by RAC. Intriguingly, after RAC, kidney fibroblasts were arrested at the G2/M phase. Repeated treatment with paclitaxel as an inducer of G2/M arrest upregulated p21, α-SMA, and fibronectin in the kidney fibroblasts. Taken together, these data suggest that RAC transforms kidney fibroblasts into myofibroblasts through G2/M arrest and cellular senescence." @default.
- W4309091838 created "2022-11-21" @default.
- W4309091838 creator A5004830252 @default.
- W4309091838 creator A5008602238 @default.
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- W4309091838 creator A5054761857 @default.
- W4309091838 date "2022-11-02" @default.
- W4309091838 modified "2023-10-18" @default.
- W4309091838 title "Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence" @default.
- W4309091838 cites W1501553071 @default.
- W4309091838 cites W1505584712 @default.
- W4309091838 cites W1539004296 @default.
- W4309091838 cites W1591236566 @default.
- W4309091838 cites W1965699247 @default.
- W4309091838 cites W1967880683 @default.
- W4309091838 cites W1973246225 @default.
- W4309091838 cites W1983097616 @default.
- W4309091838 cites W1983965827 @default.
- W4309091838 cites W1990815825 @default.
- W4309091838 cites W1995205742 @default.
- W4309091838 cites W2004809264 @default.
- W4309091838 cites W2007950411 @default.
- W4309091838 cites W2008553572 @default.
- W4309091838 cites W2010345740 @default.
- W4309091838 cites W2011144569 @default.
- W4309091838 cites W2016318035 @default.
- W4309091838 cites W2029026343 @default.
- W4309091838 cites W2031459560 @default.
- W4309091838 cites W2032428064 @default.
- W4309091838 cites W2035115018 @default.
- W4309091838 cites W2035685698 @default.
- W4309091838 cites W2039239477 @default.
- W4309091838 cites W2039592355 @default.
- W4309091838 cites W2040371936 @default.
- W4309091838 cites W2045388444 @default.
- W4309091838 cites W2052158179 @default.
- W4309091838 cites W205357504 @default.
- W4309091838 cites W2067299834 @default.
- W4309091838 cites W2068050227 @default.
- W4309091838 cites W2068287262 @default.
- W4309091838 cites W2070575025 @default.
- W4309091838 cites W2074983969 @default.
- W4309091838 cites W2077827444 @default.
- W4309091838 cites W2077967941 @default.
- W4309091838 cites W2080125477 @default.
- W4309091838 cites W2104770727 @default.
- W4309091838 cites W2106887481 @default.
- W4309091838 cites W2111450457 @default.
- W4309091838 cites W2114750406 @default.
- W4309091838 cites W2119983127 @default.
- W4309091838 cites W2122135456 @default.
- W4309091838 cites W2125855766 @default.
- W4309091838 cites W2129122050 @default.
- W4309091838 cites W2132402892 @default.
- W4309091838 cites W2135564059 @default.
- W4309091838 cites W2143349604 @default.
- W4309091838 cites W2143722415 @default.
- W4309091838 cites W2148556702 @default.
- W4309091838 cites W2156935689 @default.
- W4309091838 cites W2157033538 @default.
- W4309091838 cites W2178451514 @default.
- W4309091838 cites W2238319240 @default.
- W4309091838 cites W2314722778 @default.
- W4309091838 cites W2320766625 @default.
- W4309091838 cites W2337424574 @default.
- W4309091838 cites W2343423203 @default.
- W4309091838 cites W2411149830 @default.
- W4309091838 cites W2460256039 @default.
- W4309091838 cites W2547947654 @default.
- W4309091838 cites W2582602949 @default.
- W4309091838 cites W2606607751 @default.
- W4309091838 cites W2608199474 @default.
- W4309091838 cites W2617564874 @default.
- W4309091838 cites W2624008928 @default.
- W4309091838 cites W2738581806 @default.
- W4309091838 cites W2754332201 @default.
- W4309091838 cites W2808549672 @default.
- W4309091838 cites W2895160592 @default.
- W4309091838 cites W2896678910 @default.
- W4309091838 cites W2911928150 @default.
- W4309091838 cites W2947440773 @default.
- W4309091838 cites W2968770226 @default.
- W4309091838 cites W2970664220 @default.
- W4309091838 cites W2973873625 @default.
- W4309091838 cites W2977987787 @default.
- W4309091838 cites W2999464103 @default.
- W4309091838 cites W3012451273 @default.
- W4309091838 cites W3016622249 @default.
- W4309091838 cites W3121092566 @default.
- W4309091838 cites W3164010671 @default.
- W4309091838 cites W3172470241 @default.
- W4309091838 cites W4213050997 @default.
- W4309091838 cites W4221034800 @default.
- W4309091838 cites W4250210754 @default.
- W4309091838 cites W4280529518 @default.
- W4309091838 cites W4281702843 @default.
- W4309091838 cites W4292379725 @default.
- W4309091838 cites W4292546280 @default.