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- W4309102011 abstract "<b>Context:</b> The role of metabolic hormones, medicinal plants and their interrelationships in the control of human reproductive processes are poorly understood. <b>Aims:</b> To examine how leptin, obestatin and ginkgo (<i>Ginkgo biloba</i> L.) affect human ovarian hormone release. <b>Methods:</b> We analysed the influence of leptin and obestatin alone and in combination with ginkgo extract on cultured human ovarian granulosa cells. The release of progesterone (P), insulin-like growth factor I (IGF-I), oxytocin (OT) and prostaglandin F (PGF) were analysed by enzyme immunoassay and enzyme-linked immunosorbent assay. <b>Key results:</b> Leptin addition promoted the release of all the measured hormones. Obestatin stimulated the release of P, IGF-I and OT and inhibited PGF output. Ginkgo suppressed P, IGF-I and OT and promoted PGF release. Furthermore, ginkgo changed the stimulatory action of leptin on PGF to an inhibitory one. <b>Conclusions:</b> Leptin and obestatin are involved in the control of human ovarian hormone release and ginkgo influences their function. <b>Implications:</b> Leptin and obestatin could be useful as stimulators of human ovarian cell functions. The suppressive influence of ginkgo on ovarian function should lead to the development of ginkgo-containing drugs." @default.
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- W4309102011 date "2022-11-16" @default.
- W4309102011 modified "2023-09-28" @default.
- W4309102011 title "<i>Corrigendum to</i>: Direct action of leptin, obestatin and ginkgo on hormone release by luteinised human ovarian granulosa cells" @default.
- W4309102011 doi "https://doi.org/10.1071/rd22154_co" @default.
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