FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309103065> ?p ?o ?g. }

• W4309103065 abstract "Summary Peroxiredoxins (Prdx) utilize reversibly oxidized cysteine residues to reduce peroxides but also to promote H 2 O 2 signal transduction, including H 2 O 2 -induced activation of P38 MAPK. Prdx form H 2 O 2 -induced disulfide complexes with many proteins, including multiple kinases involved in P38 MAPK signaling. Here we show that a genetically-encoded fusion between Prdx and the P38 MAPK is sufficient to hyperactivate the kinase in yeast and human cells by a mechanism that does not require the H 2 O 2 -sensing cysteine of the Prdx. In yeast, we demonstrate that a P38-Prdx fusion protein compensates for the loss of a scaffold protein and upstream MAP3K kinase activity, driving entry into mitosis. Based on our findings, we propose that the H 2 O 2 -induced formation of Prdx-MAPK disulfide complexes provides a scaffold and signaling platform for MAPKK-MAPK signaling. The demonstration that formation of a complex with a Prdx can be sufficient to modify the activity of a kinase has broad implications for peroxide-based signal transduction in eukaryotes. Highlights P38-Prdx complexes increase P38 (Sty1/MAPK14) phosphorylation in yeast and human cells The S. pombe Prdx promotes transient thioredoxin-mediated oxidation of a MAPK tyrosine phosphatase P38-Prdx complexes increase P38(Sty1) activity by phosphatase and MAP3K-independent mechanisms P38-Prdx complexes increase the stability and phosphorylation of the S. pombe P38 MAPKK (Wis1) Non-canonical, H 2 O 2 -induced autophosphorylation contributes to activation of the Wis1 MAPKK" @default.
• W4309103065 created "2022-11-22" @default.
• W4309103065 creator A5000244740 @default.
• W4309103065 creator A5008222285 @default.
• W4309103065 creator A5015794327 @default.
• W4309103065 creator A5025660430 @default.
• W4309103065 creator A5039474581 @default.
• W4309103065 creator A5039944102 @default.
• W4309103065 creator A5053806482 @default.
• W4309103065 creator A5064470685 @default.
• W4309103065 creator A5091660937 @default.
• W4309103065 date "2022-11-15" @default.
• W4309103065 modified "2023-10-14" @default.
• W4309103065 title "A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms" @default.
• W4309103065 cites W1669539776 @default.
• W4309103065 cites W1964296070 @default.
• W4309103065 cites W1965909642 @default.
• W4309103065 cites W1975084717 @default.
• W4309103065 cites W1975189886 @default.
• W4309103065 cites W1979633995 @default.
• W4309103065 cites W1981786531 @default.
• W4309103065 cites W1991952977 @default.
• W4309103065 cites W1994500027 @default.
• W4309103065 cites W1997884577 @default.
• W4309103065 cites W2001991555 @default.
• W4309103065 cites W2007636933 @default.
• W4309103065 cites W2008144053 @default.
• W4309103065 cites W2012713600 @default.
• W4309103065 cites W2017789801 @default.
• W4309103065 cites W2018876412 @default.
• W4309103065 cites W2021773210 @default.
• W4309103065 cites W2023436768 @default.
• W4309103065 cites W2026030222 @default.
• W4309103065 cites W2027756065 @default.
• W4309103065 cites W2031729422 @default.
• W4309103065 cites W2032624656 @default.
• W4309103065 cites W2038862228 @default.
• W4309103065 cites W2041303655 @default.
• W4309103065 cites W2043513358 @default.
• W4309103065 cites W2043949158 @default.
• W4309103065 cites W2058881502 @default.
• W4309103065 cites W2060630008 @default.
• W4309103065 cites W2061472035 @default.
• W4309103065 cites W2062901635 @default.
• W4309103065 cites W2068697011 @default.
• W4309103065 cites W2079310705 @default.
• W4309103065 cites W2084567952 @default.
• W4309103065 cites W2085076729 @default.
• W4309103065 cites W2098039543 @default.
• W4309103065 cites W2100254469 @default.
• W4309103065 cites W2105405279 @default.
• W4309103065 cites W2106319995 @default.
• W4309103065 cites W2111586212 @default.
• W4309103065 cites W2116874572 @default.
• W4309103065 cites W2117909268 @default.
• W4309103065 cites W2126890082 @default.
• W4309103065 cites W2137749197 @default.
• W4309103065 cites W2144192813 @default.
• W4309103065 cites W2161408324 @default.
• W4309103065 cites W2165348821 @default.
• W4309103065 cites W2169919744 @default.
• W4309103065 cites W2290835444 @default.
• W4309103065 cites W2508503153 @default.
• W4309103065 cites W2530311451 @default.
• W4309103065 cites W2559778626 @default.
• W4309103065 cites W2602302233 @default.
• W4309103065 cites W2624994649 @default.
• W4309103065 cites W2674118028 @default.
• W4309103065 cites W2737301841 @default.
• W4309103065 cites W2778452486 @default.
• W4309103065 cites W2895044684 @default.
• W4309103065 cites W2980291105 @default.
• W4309103065 cites W2996405642 @default.
• W4309103065 cites W3000058993 @default.
• W4309103065 cites W3010908253 @default.
• W4309103065 cites W3027079541 @default.
• W4309103065 cites W3039594397 @default.
• W4309103065 cites W3089898280 @default.
• W4309103065 cites W3094568333 @default.
• W4309103065 cites W3122470240 @default.
• W4309103065 cites W3124959162 @default.
• W4309103065 cites W3153129524 @default.
• W4309103065 cites W3153200590 @default.
• W4309103065 cites W4225253450 @default.
• W4309103065 doi "https://doi.org/10.1101/2022.11.15.513554" @default.
• W4309103065 hasPublicationYear "2022" @default.
• W4309103065 type Work @default.
• W4309103065 citedByCount "0" @default.
• W4309103065 crossrefType "posted-content" @default.
• W4309103065 hasAuthorship W4309103065A5000244740 @default.
• W4309103065 hasAuthorship W4309103065A5008222285 @default.
• W4309103065 hasAuthorship W4309103065A5015794327 @default.
• W4309103065 hasAuthorship W4309103065A5025660430 @default.
• W4309103065 hasAuthorship W4309103065A5039474581 @default.
• W4309103065 hasAuthorship W4309103065A5039944102 @default.
• W4309103065 hasAuthorship W4309103065A5053806482 @default.
• W4309103065 hasAuthorship W4309103065A5064470685 @default.
• W4309103065 hasAuthorship W4309103065A5091660937 @default.
• W4309103065 hasBestOaLocation W43091030651 @default.
• W4309103065 hasConcept C11960822 @default.

• next