FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309109411> ?p ?o ?g. }

• W4309109411 abstract "ABSTRACT Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder linked to numerous rare, inherited and arising de novo genetic variants. ASD often co-occurs with attention-deficit hyperactivity disorder and epilepsy, which are associated with hyperexcitability of neurons. However, the physiological and molecular mechanisms underlying hyperexcitability in ASD remain poorly understood. Transient receptor potential canonical-6 (TRPC6) is a Ca 2+ -permeable cation channel that regulates store-operated calcium entry (SOCE) and is a candidate risk gene for ASD. Using human pluripotent stem cell (hPSC)-derived cortical neurons, single cell calcium imaging, and electrophysiological recording, we show that TRPC6 knockout (KO) reduces SOCE signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency. Our data provide evidence that reduction of SOCE by TRPC6 KO results in neuronal hyperexcitability, which we hypothesize is an important contributor to the cellular pathophysiology underlying hyperactivity in some ASD." @default.
• W4309109411 created "2022-11-22" @default.
• W4309109411 creator A5002882806 @default.
• W4309109411 creator A5004464420 @default.
• W4309109411 creator A5009735236 @default.
• W4309109411 creator A5035528777 @default.
• W4309109411 creator A5050285244 @default.
• W4309109411 creator A5054830010 @default.
• W4309109411 creator A5085015270 @default.
• W4309109411 creator A5090518250 @default.
• W4309109411 date "2022-11-14" @default.
• W4309109411 modified "2023-10-17" @default.
• W4309109411 title "Deletion of<i>TRPC6</i>, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells" @default.
• W4309109411 cites W1485297825 @default.
• W4309109411 cites W1486039058 @default.
• W4309109411 cites W1571662784 @default.
• W4309109411 cites W1981050975 @default.
• W4309109411 cites W2001917660 @default.
• W4309109411 cites W2007621703 @default.
• W4309109411 cites W2029949863 @default.
• W4309109411 cites W2033740326 @default.
• W4309109411 cites W2046694790 @default.
• W4309109411 cites W2052703460 @default.
• W4309109411 cites W2055479746 @default.
• W4309109411 cites W2063266096 @default.
• W4309109411 cites W2070832223 @default.
• W4309109411 cites W2073154969 @default.
• W4309109411 cites W2076127858 @default.
• W4309109411 cites W2082314612 @default.
• W4309109411 cites W2085287703 @default.
• W4309109411 cites W2095352259 @default.
• W4309109411 cites W2102278945 @default.
• W4309109411 cites W2114104545 @default.
• W4309109411 cites W2138207763 @default.
• W4309109411 cites W2138977668 @default.
• W4309109411 cites W2141224543 @default.
• W4309109411 cites W2148508607 @default.
• W4309109411 cites W2168853747 @default.
• W4309109411 cites W2240467006 @default.
• W4309109411 cites W2527696682 @default.
• W4309109411 cites W2562909145 @default.
• W4309109411 cites W2794362013 @default.
• W4309109411 cites W2812258346 @default.
• W4309109411 cites W2885986299 @default.
• W4309109411 cites W2895519165 @default.
• W4309109411 cites W2898554275 @default.
• W4309109411 cites W2917207851 @default.
• W4309109411 cites W2952538968 @default.
• W4309109411 cites W2969167159 @default.
• W4309109411 cites W2991559981 @default.
• W4309109411 cites W2997813281 @default.
• W4309109411 cites W3130943263 @default.
• W4309109411 cites W4214479707 @default.
• W4309109411 cites W4225270006 @default.
• W4309109411 cites W4245770531 @default.
• W4309109411 doi "https://doi.org/10.1101/2022.11.14.516407" @default.
• W4309109411 hasPublicationYear "2022" @default.
• W4309109411 type Work @default.
• W4309109411 citedByCount "0" @default.
• W4309109411 crossrefType "posted-content" @default.
• W4309109411 hasAuthorship W4309109411A5002882806 @default.
• W4309109411 hasAuthorship W4309109411A5004464420 @default.
• W4309109411 hasAuthorship W4309109411A5009735236 @default.
• W4309109411 hasAuthorship W4309109411A5035528777 @default.
• W4309109411 hasAuthorship W4309109411A5050285244 @default.
• W4309109411 hasAuthorship W4309109411A5054830010 @default.
• W4309109411 hasAuthorship W4309109411A5085015270 @default.
• W4309109411 hasAuthorship W4309109411A5090518250 @default.
• W4309109411 hasBestOaLocation W43091094111 @default.
• W4309109411 hasConcept C104317684 @default.
• W4309109411 hasConcept C107459253 @default.
• W4309109411 hasConcept C118552586 @default.
• W4309109411 hasConcept C128448793 @default.
• W4309109411 hasConcept C145103041 @default.
• W4309109411 hasConcept C155164980 @default.
• W4309109411 hasConcept C15744967 @default.
• W4309109411 hasConcept C169760540 @default.
• W4309109411 hasConcept C170493617 @default.
• W4309109411 hasConcept C205778803 @default.
• W4309109411 hasConcept C2778186239 @default.
• W4309109411 hasConcept C2778538070 @default.
• W4309109411 hasConcept C2779388368 @default.
• W4309109411 hasConcept C54355233 @default.
• W4309109411 hasConcept C86803240 @default.
• W4309109411 hasConceptScore W4309109411C104317684 @default.
• W4309109411 hasConceptScore W4309109411C107459253 @default.
• W4309109411 hasConceptScore W4309109411C118552586 @default.
• W4309109411 hasConceptScore W4309109411C128448793 @default.
• W4309109411 hasConceptScore W4309109411C145103041 @default.
• W4309109411 hasConceptScore W4309109411C155164980 @default.
• W4309109411 hasConceptScore W4309109411C15744967 @default.
• W4309109411 hasConceptScore W4309109411C169760540 @default.
• W4309109411 hasConceptScore W4309109411C170493617 @default.
• W4309109411 hasConceptScore W4309109411C205778803 @default.
• W4309109411 hasConceptScore W4309109411C2778186239 @default.
• W4309109411 hasConceptScore W4309109411C2778538070 @default.
• W4309109411 hasConceptScore W4309109411C2779388368 @default.
• W4309109411 hasConceptScore W4309109411C54355233 @default.
• W4309109411 hasConceptScore W4309109411C86803240 @default.
• W4309109411 hasLocation W43091094111 @default.

• next