FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309144619> ?p ?o ?g. }

• W4309144619 abstract "Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer.Five SNPs in GTF2H1 and four SNPs in RAD54L2 in 506 patients with lung cancer and 510 age-and gender-matched healthy controls were genotyped via the Agena MassARRAY platform. The influence of GTF2H1 and RAD54L2 polymorphisms on lung cancer susceptibility was assessed using logistic regression analysis by calculating odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).RAD54L2 rs9864693 GC genotype increased the risk of lung cancer (OR = 1.33, 95%CI: 1.01-1.77, p = 0.045). Stratified analysis found that associations of RAD54L2 rs11720298, RAD54L2 rs4687592, RAD54L2 rs9864693 and GTF2H1 rs4150667 with lung cancer risk were found in subjects aged ≤ 59 years. Precisely, a protective effect of RAD54L2 rs11720298 on the occurrence of lung cancer was observed in non-smokers and drinkers. GTF2H1 rs4150667 was associated with a decreased risk of lung cancer in subjects with BMI ≤ 24 kg/m2. RAD54L2 rs4687592 was associated with an increased risk of lung cancer in drinkers. In addition, GTF2H1 rs3802967 was associated with a reduced risk of lung squamous cell carcinoma.Our study first revealed that RAD54L2 rs9864693 was associated with an increased risk of lung cancer in the Chinese Han population. This study may increase the understanding of the effect of RAD54L2 and GTF2H1 polymorphisms on lung cancer occurrence." @default.
• W4309144619 created "2022-11-23" @default.
• W4309144619 creator A5010841768 @default.
• W4309144619 creator A5014390459 @default.
• W4309144619 creator A5036251125 @default.
• W4309144619 creator A5054119070 @default.
• W4309144619 creator A5063514061 @default.
• W4309144619 creator A5067515697 @default.
• W4309144619 creator A5067582073 @default.
• W4309144619 date "2022-11-16" @default.
• W4309144619 modified "2023-09-25" @default.
• W4309144619 title "Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population" @default.
• W4309144619 cites W1856707437 @default.
• W4309144619 cites W1974384166 @default.
• W4309144619 cites W1974618278 @default.
• W4309144619 cites W2002900988 @default.
• W4309144619 cites W2008970985 @default.
• W4309144619 cites W2012617905 @default.
• W4309144619 cites W2038684002 @default.
• W4309144619 cites W2072192494 @default.
• W4309144619 cites W2081375417 @default.
• W4309144619 cites W2106323628 @default.
• W4309144619 cites W2120891680 @default.
• W4309144619 cites W2132630169 @default.
• W4309144619 cites W2149208170 @default.
• W4309144619 cites W2170992955 @default.
• W4309144619 cites W2272984102 @default.
• W4309144619 cites W2281897355 @default.
• W4309144619 cites W2416200080 @default.
• W4309144619 cites W2433609234 @default.
• W4309144619 cites W2580112796 @default.
• W4309144619 cites W2781013518 @default.
• W4309144619 cites W2889646458 @default.
• W4309144619 cites W2891524375 @default.
• W4309144619 cites W2892858628 @default.
• W4309144619 cites W2894538486 @default.
• W4309144619 cites W2976462966 @default.
• W4309144619 doi "https://doi.org/10.1186/s12885-022-10303-1" @default.
• W4309144619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36384536" @default.
• W4309144619 hasPublicationYear "2022" @default.
• W4309144619 type Work @default.
• W4309144619 citedByCount "0" @default.
• W4309144619 crossrefType "journal-article" @default.
• W4309144619 hasAuthorship W4309144619A5010841768 @default.
• W4309144619 hasAuthorship W4309144619A5014390459 @default.
• W4309144619 hasAuthorship W4309144619A5036251125 @default.
• W4309144619 hasAuthorship W4309144619A5054119070 @default.
• W4309144619 hasAuthorship W4309144619A5063514061 @default.
• W4309144619 hasAuthorship W4309144619A5067515697 @default.
• W4309144619 hasAuthorship W4309144619A5067582073 @default.
• W4309144619 hasBestOaLocation W43091446191 @default.
• W4309144619 hasConcept C104317684 @default.
• W4309144619 hasConcept C121608353 @default.
• W4309144619 hasConcept C126322002 @default.
• W4309144619 hasConcept C135763542 @default.
• W4309144619 hasConcept C143998085 @default.
• W4309144619 hasConcept C153209595 @default.
• W4309144619 hasConcept C156957248 @default.
• W4309144619 hasConcept C2776256026 @default.
• W4309144619 hasConcept C2779372377 @default.
• W4309144619 hasConcept C2780140570 @default.
• W4309144619 hasConcept C2908647359 @default.
• W4309144619 hasConcept C54355233 @default.
• W4309144619 hasConcept C71924100 @default.
• W4309144619 hasConcept C86803240 @default.
• W4309144619 hasConcept C99454951 @default.
• W4309144619 hasConceptScore W4309144619C104317684 @default.
• W4309144619 hasConceptScore W4309144619C121608353 @default.
• W4309144619 hasConceptScore W4309144619C126322002 @default.
• W4309144619 hasConceptScore W4309144619C135763542 @default.
• W4309144619 hasConceptScore W4309144619C143998085 @default.
• W4309144619 hasConceptScore W4309144619C153209595 @default.
• W4309144619 hasConceptScore W4309144619C156957248 @default.
• W4309144619 hasConceptScore W4309144619C2776256026 @default.
• W4309144619 hasConceptScore W4309144619C2779372377 @default.
• W4309144619 hasConceptScore W4309144619C2780140570 @default.
• W4309144619 hasConceptScore W4309144619C2908647359 @default.
• W4309144619 hasConceptScore W4309144619C54355233 @default.
• W4309144619 hasConceptScore W4309144619C71924100 @default.
• W4309144619 hasConceptScore W4309144619C86803240 @default.
• W4309144619 hasConceptScore W4309144619C99454951 @default.
• W4309144619 hasIssue "1" @default.
• W4309144619 hasLocation W43091446191 @default.
• W4309144619 hasLocation W43091446192 @default.
• W4309144619 hasLocation W43091446193 @default.
• W4309144619 hasLocation W43091446194 @default.
• W4309144619 hasOpenAccess W4309144619 @default.
• W4309144619 hasPrimaryLocation W43091446191 @default.
• W4309144619 hasRelatedWork W1992586115 @default.
• W4309144619 hasRelatedWork W2012120628 @default.
• W4309144619 hasRelatedWork W2130084557 @default.
• W4309144619 hasRelatedWork W2135480374 @default.
• W4309144619 hasRelatedWork W2263513184 @default.
• W4309144619 hasRelatedWork W2414000003 @default.
• W4309144619 hasRelatedWork W2415131133 @default.
• W4309144619 hasRelatedWork W2783341158 @default.
• W4309144619 hasRelatedWork W2912603490 @default.
• W4309144619 hasRelatedWork W2958841296 @default.
• W4309144619 hasVolume "22" @default.
• W4309144619 isParatext "false" @default.

• next