Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309149915> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4309149915 abstract "Abstract (1) Background: Lung adenocarcinomas (LUAD) are the predominant lung non-small cell cancer subtype (NSCLC), accounting for approximately 50%. miR-183-5p from LUAD exosomes could promote the migration of LUAD and become a potential biomarker for LUAD; (2) Methods: Exosomes are enriched from LUAD BALF and A549 cancer cells to identify the role of miR-183-5p in LUAD by transmission electron microscopy, particle size analysis, and fluorescence microscope. TCGA and gene set enrichment analysis (GSEA) data sets are used to analyze the expression of miR-183-5p. q-PCR and Western blot are performed to the existence and the target of miR-183-5p. Wound healing and Transwell assays are conducted to explore the function of miR-183-5p in LUAD; (3) Results: We identify the particle size of BALF exosomes in LUAD patients and control groups through NTA and find BALF exosomes in LUAD patients promote the invasion and migration of LUAD cells and EMT process through Wound healing and Transwell assays. The analysis of sequencing data and the mining of TCGA data show that miR-183-5p is highly expressed in LUAD tissue and blood. It is further verified by q-PCR that compared with the control group, the expression of miR-183-5p in BALF secretion of LUAD patients is also upregulated. Furthermore, miR-183-5p could promote the migration of A549 cells and inhibit the expression of PTEN, as well as the BALF exosomes from LUAD patients through Wound healing and Transwell experiments; (4) Conclusions: LUAD BALF exosomes can promote the migration and EMT process of A549 cells by up-regulated miR-183-5p, which targets PTEN through exosome transport." @default.
- W4309149915 created "2022-11-23" @default.
- W4309149915 creator A5020603910 @default.
- W4309149915 creator A5042973046 @default.
- W4309149915 date "2022-11-16" @default.
- W4309149915 modified "2023-09-24" @default.
- W4309149915 title "LUAD BALF Exosomal miR-183-5p promoted the metastasis of NLCSC" @default.
- W4309149915 cites W1985458075 @default.
- W4309149915 cites W2109298880 @default.
- W4309149915 cites W2115277036 @default.
- W4309149915 cites W2121354606 @default.
- W4309149915 cites W2139000046 @default.
- W4309149915 cites W2155772921 @default.
- W4309149915 cites W2280881439 @default.
- W4309149915 cites W2626275255 @default.
- W4309149915 cites W2725377209 @default.
- W4309149915 cites W2766002642 @default.
- W4309149915 cites W2786250407 @default.
- W4309149915 cites W2807144840 @default.
- W4309149915 cites W2909952889 @default.
- W4309149915 cites W2984525836 @default.
- W4309149915 cites W3022292509 @default.
- W4309149915 cites W3089508433 @default.
- W4309149915 cites W3128646645 @default.
- W4309149915 cites W3130094341 @default.
- W4309149915 cites W3134783654 @default.
- W4309149915 cites W4210274138 @default.
- W4309149915 cites W4234236664 @default.
- W4309149915 cites W4243930828 @default.
- W4309149915 doi "https://doi.org/10.21203/rs.3.rs-2259140/v1" @default.
- W4309149915 hasPublicationYear "2022" @default.
- W4309149915 type Work @default.
- W4309149915 citedByCount "0" @default.
- W4309149915 crossrefType "posted-content" @default.
- W4309149915 hasAuthorship W4309149915A5020603910 @default.
- W4309149915 hasAuthorship W4309149915A5042973046 @default.
- W4309149915 hasBestOaLocation W43091499151 @default.
- W4309149915 hasConcept C104317684 @default.
- W4309149915 hasConcept C121608353 @default.
- W4309149915 hasConcept C126322002 @default.
- W4309149915 hasConcept C127561419 @default.
- W4309149915 hasConcept C143998085 @default.
- W4309149915 hasConcept C145059251 @default.
- W4309149915 hasConcept C203014093 @default.
- W4309149915 hasConcept C20518536 @default.
- W4309149915 hasConcept C2776256026 @default.
- W4309149915 hasConcept C2776415932 @default.
- W4309149915 hasConcept C2777609662 @default.
- W4309149915 hasConcept C2779013556 @default.
- W4309149915 hasConcept C2780269544 @default.
- W4309149915 hasConcept C2781182431 @default.
- W4309149915 hasConcept C502942594 @default.
- W4309149915 hasConcept C55493867 @default.
- W4309149915 hasConcept C62478195 @default.
- W4309149915 hasConcept C71924100 @default.
- W4309149915 hasConcept C81729549 @default.
- W4309149915 hasConcept C86554907 @default.
- W4309149915 hasConcept C86803240 @default.
- W4309149915 hasConcept C95444343 @default.
- W4309149915 hasConceptScore W4309149915C104317684 @default.
- W4309149915 hasConceptScore W4309149915C121608353 @default.
- W4309149915 hasConceptScore W4309149915C126322002 @default.
- W4309149915 hasConceptScore W4309149915C127561419 @default.
- W4309149915 hasConceptScore W4309149915C143998085 @default.
- W4309149915 hasConceptScore W4309149915C145059251 @default.
- W4309149915 hasConceptScore W4309149915C203014093 @default.
- W4309149915 hasConceptScore W4309149915C20518536 @default.
- W4309149915 hasConceptScore W4309149915C2776256026 @default.
- W4309149915 hasConceptScore W4309149915C2776415932 @default.
- W4309149915 hasConceptScore W4309149915C2777609662 @default.
- W4309149915 hasConceptScore W4309149915C2779013556 @default.
- W4309149915 hasConceptScore W4309149915C2780269544 @default.
- W4309149915 hasConceptScore W4309149915C2781182431 @default.
- W4309149915 hasConceptScore W4309149915C502942594 @default.
- W4309149915 hasConceptScore W4309149915C55493867 @default.
- W4309149915 hasConceptScore W4309149915C62478195 @default.
- W4309149915 hasConceptScore W4309149915C71924100 @default.
- W4309149915 hasConceptScore W4309149915C81729549 @default.
- W4309149915 hasConceptScore W4309149915C86554907 @default.
- W4309149915 hasConceptScore W4309149915C86803240 @default.
- W4309149915 hasConceptScore W4309149915C95444343 @default.
- W4309149915 hasLocation W43091499151 @default.
- W4309149915 hasOpenAccess W4309149915 @default.
- W4309149915 hasPrimaryLocation W43091499151 @default.
- W4309149915 hasRelatedWork W1975859778 @default.
- W4309149915 hasRelatedWork W2081501617 @default.
- W4309149915 hasRelatedWork W2086750497 @default.
- W4309149915 hasRelatedWork W2411027382 @default.
- W4309149915 hasRelatedWork W2542904087 @default.
- W4309149915 hasRelatedWork W2766741267 @default.
- W4309149915 hasRelatedWork W3032711261 @default.
- W4309149915 hasRelatedWork W3085616253 @default.
- W4309149915 hasRelatedWork W3128024900 @default.
- W4309149915 hasRelatedWork W3184603486 @default.
- W4309149915 isParatext "false" @default.
- W4309149915 isRetracted "false" @default.
- W4309149915 workType "article" @default.