Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309149916> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4309149916 abstract "Abstract The retina has the greatest metabolic demand in the body particularly in dark adaptation when its sensitivity is enhanced. This requires an elevated levels of perfusion to sustain mitochondrial activity. However, mitochondrial performance declines with age leading to reduced adaptive ability. We assessed human retinal metabolism in vivo using broadband near-infrared spectroscopy (bNIRS), which records colour changes in mitochondria and blood as retinal metabolism shifts in response to changes in environmental luminance. We demonstrate a significant sustained rise in mitochondrial oxidative metabolism in the first 3 min of darkness in subjects under 50 years old. This was not seen in over 50s. Choroidal oxygenation declines in <50s as mitochondrial metabolism increases, but gradually rises in >50s. Significant group differences in blood oxygenation are apparent in the first 6 min, consistent with mitochondrial demand leading hemodynamic changes. A greater coupling between mitochondrial oxidative metabolism with hemodynamics is revealed in subjects older than 50, possibly due to reduced capacity in the older retina. Rapid in vivo assessment of retinal metabolism with bNIRS provides a route to understanding fundamental physiology and early identification of retinal disease before pathology is established." @default.
- W4309149916 created "2022-11-23" @default.
- W4309149916 creator A5066434934 @default.
- W4309149916 creator A5068293187 @default.
- W4309149916 creator A5085406999 @default.
- W4309149916 creator A5089232995 @default.
- W4309149916 date "2022-11-16" @default.
- W4309149916 modified "2023-09-23" @default.
- W4309149916 title "Watching the human retina breath in real time; the slowing of mitochondrial respiration with age in dark adaptation" @default.
- W4309149916 doi "https://doi.org/10.21203/rs.3.rs-2258694/v1" @default.
- W4309149916 hasPublicationYear "2022" @default.
- W4309149916 type Work @default.
- W4309149916 citedByCount "0" @default.
- W4309149916 crossrefType "posted-content" @default.
- W4309149916 hasAuthorship W4309149916A5066434934 @default.
- W4309149916 hasAuthorship W4309149916A5068293187 @default.
- W4309149916 hasAuthorship W4309149916A5085406999 @default.
- W4309149916 hasAuthorship W4309149916A5089232995 @default.
- W4309149916 hasBestOaLocation W43091499161 @default.
- W4309149916 hasConcept C105702510 @default.
- W4309149916 hasConcept C126322002 @default.
- W4309149916 hasConcept C134018914 @default.
- W4309149916 hasConcept C146957229 @default.
- W4309149916 hasConcept C169760540 @default.
- W4309149916 hasConcept C178853913 @default.
- W4309149916 hasConcept C182215343 @default.
- W4309149916 hasConcept C18903297 @default.
- W4309149916 hasConcept C2777093970 @default.
- W4309149916 hasConcept C2780827179 @default.
- W4309149916 hasConcept C28859421 @default.
- W4309149916 hasConcept C2994198108 @default.
- W4309149916 hasConcept C42407357 @default.
- W4309149916 hasConcept C55493867 @default.
- W4309149916 hasConcept C57600042 @default.
- W4309149916 hasConcept C62231903 @default.
- W4309149916 hasConcept C70289976 @default.
- W4309149916 hasConcept C71924100 @default.
- W4309149916 hasConcept C86803240 @default.
- W4309149916 hasConcept C95444343 @default.
- W4309149916 hasConceptScore W4309149916C105702510 @default.
- W4309149916 hasConceptScore W4309149916C126322002 @default.
- W4309149916 hasConceptScore W4309149916C134018914 @default.
- W4309149916 hasConceptScore W4309149916C146957229 @default.
- W4309149916 hasConceptScore W4309149916C169760540 @default.
- W4309149916 hasConceptScore W4309149916C178853913 @default.
- W4309149916 hasConceptScore W4309149916C182215343 @default.
- W4309149916 hasConceptScore W4309149916C18903297 @default.
- W4309149916 hasConceptScore W4309149916C2777093970 @default.
- W4309149916 hasConceptScore W4309149916C2780827179 @default.
- W4309149916 hasConceptScore W4309149916C28859421 @default.
- W4309149916 hasConceptScore W4309149916C2994198108 @default.
- W4309149916 hasConceptScore W4309149916C42407357 @default.
- W4309149916 hasConceptScore W4309149916C55493867 @default.
- W4309149916 hasConceptScore W4309149916C57600042 @default.
- W4309149916 hasConceptScore W4309149916C62231903 @default.
- W4309149916 hasConceptScore W4309149916C70289976 @default.
- W4309149916 hasConceptScore W4309149916C71924100 @default.
- W4309149916 hasConceptScore W4309149916C86803240 @default.
- W4309149916 hasConceptScore W4309149916C95444343 @default.
- W4309149916 hasLocation W43091499161 @default.
- W4309149916 hasOpenAccess W4309149916 @default.
- W4309149916 hasPrimaryLocation W43091499161 @default.
- W4309149916 hasRelatedWork W1990015538 @default.
- W4309149916 hasRelatedWork W2063441939 @default.
- W4309149916 hasRelatedWork W2090098702 @default.
- W4309149916 hasRelatedWork W2100971706 @default.
- W4309149916 hasRelatedWork W2406789889 @default.
- W4309149916 hasRelatedWork W2408940622 @default.
- W4309149916 hasRelatedWork W2412664293 @default.
- W4309149916 hasRelatedWork W2425321276 @default.
- W4309149916 hasRelatedWork W41716726 @default.
- W4309149916 hasRelatedWork W4382677828 @default.
- W4309149916 isParatext "false" @default.
- W4309149916 isRetracted "false" @default.
- W4309149916 workType "article" @default.