FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309153007> ?p ?o ?g. }

• W4309153007 endingPage "14123" @default.
• W4309153007 startingPage "14123" @default.
• W4309153007 abstract "This study is preliminary to an experiment to be performed onboard the International Space Station (ISS) and on Earth to investigate how low gravity influences the healing of sutured human skin and vein wounds. Its objective was to ascertain whether these tissue explants could be maintained to be viable ex vivo for long periods of time, mimicking the experimental conditions onboard the ISS. We developed an automated tissue culture chamber, reproducing and monitoring the physiological tensile forces over time, and a culture medium enriched with serelaxin (60 ng/mL) and (Zn(PipNONO)Cl) (28 ng/mL), known to extend viability of explanted organs for transplantation. The results show that the human skin and vein specimens remained viable for more than 4 weeks, with no substantial signs of damage in their tissues and cells. As a further clue about cell viability, some typical events associated with wound repair were observed in the tissue areas close to the wound, namely remodeling of collagen fibers in the papillary dermis and of elastic fibers in the vein wall, proliferation of keratinocyte stem cells, and expression of the endothelial functional markers eNOS and FGF-2. These findings validate the suitability of this new ex vivo organ culture system for wound healing studies, not only for the scheduled space experiment but also for applications on Earth, such as drug discovery purposes." @default.
• W4309153007 created "2022-11-24" @default.
• W4309153007 creator A5001029921 @default.
• W4309153007 creator A5008940063 @default.
• W4309153007 creator A5013705163 @default.
• W4309153007 creator A5014310522 @default.
• W4309153007 creator A5026308376 @default.
• W4309153007 creator A5026884187 @default.
• W4309153007 creator A5035117130 @default.
• W4309153007 creator A5042319126 @default.
• W4309153007 creator A5051047944 @default.
• W4309153007 creator A5081462422 @default.
• W4309153007 creator A5082455512 @default.
• W4309153007 creator A5086190246 @default.
• W4309153007 creator A5086541070 @default.
• W4309153007 date "2022-11-16" @default.
• W4309153007 modified "2023-10-09" @default.
• W4309153007 title "Optimization of an Ex-Vivo Human Skin/Vein Model for Long-Term Wound Healing Studies. Ground Preparatory Activities for the ‘Suture in Space’ Experiment Onboard the International Space Station" @default.
• W4309153007 cites W1608217646 @default.
• W4309153007 cites W1973335152 @default.
• W4309153007 cites W1975318062 @default.
• W4309153007 cites W2004422966 @default.
• W4309153007 cites W2023034468 @default.
• W4309153007 cites W2033633688 @default.
• W4309153007 cites W2041144325 @default.
• W4309153007 cites W2042736312 @default.
• W4309153007 cites W2045232408 @default.
• W4309153007 cites W2061804518 @default.
• W4309153007 cites W2076270502 @default.
• W4309153007 cites W2077308147 @default.
• W4309153007 cites W2105397752 @default.
• W4309153007 cites W2110843783 @default.
• W4309153007 cites W2127903487 @default.
• W4309153007 cites W2149053785 @default.
• W4309153007 cites W2325727928 @default.
• W4309153007 cites W2546645949 @default.
• W4309153007 cites W2606062902 @default.
• W4309153007 cites W2746856644 @default.
• W4309153007 cites W2784479902 @default.
• W4309153007 cites W2790252994 @default.
• W4309153007 cites W2794165558 @default.
• W4309153007 cites W2969513073 @default.
• W4309153007 cites W3022186713 @default.
• W4309153007 cites W3080253574 @default.
• W4309153007 cites W4210504076 @default.
• W4309153007 cites W4220663279 @default.
• W4309153007 cites W4281615266 @default.
• W4309153007 cites W4301398373 @default.
• W4309153007 cites W90138934 @default.
• W4309153007 cites W2442255194 @default.
• W4309153007 doi "https://doi.org/10.3390/ijms232214123" @default.
• W4309153007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430601" @default.
• W4309153007 hasPublicationYear "2022" @default.
• W4309153007 type Work @default.
• W4309153007 citedByCount "2" @default.
• W4309153007 countsByYear W43091530072023 @default.
• W4309153007 crossrefType "journal-article" @default.
• W4309153007 hasAuthorship W4309153007A5001029921 @default.
• W4309153007 hasAuthorship W4309153007A5008940063 @default.
• W4309153007 hasAuthorship W4309153007A5013705163 @default.
• W4309153007 hasAuthorship W4309153007A5014310522 @default.
• W4309153007 hasAuthorship W4309153007A5026308376 @default.
• W4309153007 hasAuthorship W4309153007A5026884187 @default.
• W4309153007 hasAuthorship W4309153007A5035117130 @default.
• W4309153007 hasAuthorship W4309153007A5042319126 @default.
• W4309153007 hasAuthorship W4309153007A5051047944 @default.
• W4309153007 hasAuthorship W4309153007A5081462422 @default.
• W4309153007 hasAuthorship W4309153007A5082455512 @default.
• W4309153007 hasAuthorship W4309153007A5086190246 @default.
• W4309153007 hasAuthorship W4309153007A5086541070 @default.
• W4309153007 hasBestOaLocation W43091530071 @default.
• W4309153007 hasConcept C136229726 @default.
• W4309153007 hasConcept C141071460 @default.
• W4309153007 hasConcept C142724271 @default.
• W4309153007 hasConcept C150903083 @default.
• W4309153007 hasConcept C190567982 @default.
• W4309153007 hasConcept C207001950 @default.
• W4309153007 hasConcept C26291073 @default.
• W4309153007 hasConcept C2777074287 @default.
• W4309153007 hasConcept C2777327002 @default.
• W4309153007 hasConcept C2777624698 @default.
• W4309153007 hasConcept C2780269544 @default.
• W4309153007 hasConcept C2911091166 @default.
• W4309153007 hasConcept C49892992 @default.
• W4309153007 hasConcept C54355233 @default.
• W4309153007 hasConcept C71924100 @default.
• W4309153007 hasConcept C81885089 @default.
• W4309153007 hasConcept C86803240 @default.
• W4309153007 hasConceptScore W4309153007C136229726 @default.
• W4309153007 hasConceptScore W4309153007C141071460 @default.
• W4309153007 hasConceptScore W4309153007C142724271 @default.
• W4309153007 hasConceptScore W4309153007C150903083 @default.
• W4309153007 hasConceptScore W4309153007C190567982 @default.
• W4309153007 hasConceptScore W4309153007C207001950 @default.
• W4309153007 hasConceptScore W4309153007C26291073 @default.
• W4309153007 hasConceptScore W4309153007C2777074287 @default.
• W4309153007 hasConceptScore W4309153007C2777327002 @default.
• W4309153007 hasConceptScore W4309153007C2777624698 @default.

• next