Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309153886> ?p ?o ?g. }
- W4309153886 endingPage "14129" @default.
- W4309153886 startingPage "14129" @default.
- W4309153886 abstract "In recent years, interest in non-coding RNAs as important physiological regulators has grown significantly. Their participation in the pathophysiology of cardiovascular diseases is extremely important. Circular RNA (circRNA) has been shown to be important in the development of heart failure. CircRNA is a closed circular structure of non-coding RNA fragments. They are formed in the nucleus, from where they are transported to the cytoplasm in a still unclear mechanism. They are mainly located in the cytoplasm or contained in exosomes. CircRNA expression varies according to the type of tissue. In the brain, almost 12% of genes produce circRNA, while in the heart it is only 9%. Recent studies indicate a key role of circRNA in cardiomyocyte hypertrophy, fibrosis, autophagy and apoptosis. CircRNAs act mainly by interacting with miRNAs through a sponge effect mechanism. The involvement of circRNA in the development of heart failure leads to the suggestion that they may be promising biomarkers and useful targets in the treatment of cardiovascular diseases. In this review, we will provide a brief introduction to circRNA and up-to-date understanding of their role in the mechanisms leading to the development of heart failure." @default.
- W4309153886 created "2022-11-24" @default.
- W4309153886 creator A5028374992 @default.
- W4309153886 creator A5042981707 @default.
- W4309153886 date "2022-11-16" @default.
- W4309153886 modified "2023-10-03" @default.
- W4309153886 title "Involvement of circRNAs in the Development of Heart Failure" @default.
- W4309153886 cites W1908289777 @default.
- W4309153886 cites W1913925477 @default.
- W4309153886 cites W1955400364 @default.
- W4309153886 cites W1966411071 @default.
- W4309153886 cites W1966557314 @default.
- W4309153886 cites W1976881265 @default.
- W4309153886 cites W1981726010 @default.
- W4309153886 cites W1989434611 @default.
- W4309153886 cites W1991430539 @default.
- W4309153886 cites W1993529637 @default.
- W4309153886 cites W1998056842 @default.
- W4309153886 cites W2001591494 @default.
- W4309153886 cites W2002958873 @default.
- W4309153886 cites W2028097684 @default.
- W4309153886 cites W2030968333 @default.
- W4309153886 cites W2038281107 @default.
- W4309153886 cites W2050862994 @default.
- W4309153886 cites W2054891772 @default.
- W4309153886 cites W2058301500 @default.
- W4309153886 cites W2058835062 @default.
- W4309153886 cites W2064165694 @default.
- W4309153886 cites W2086507603 @default.
- W4309153886 cites W2091210052 @default.
- W4309153886 cites W2100155969 @default.
- W4309153886 cites W2109393499 @default.
- W4309153886 cites W2109555634 @default.
- W4309153886 cites W2118340059 @default.
- W4309153886 cites W2127321192 @default.
- W4309153886 cites W2134943860 @default.
- W4309153886 cites W2136507361 @default.
- W4309153886 cites W2147922324 @default.
- W4309153886 cites W2166057024 @default.
- W4309153886 cites W2175910351 @default.
- W4309153886 cites W2259938310 @default.
- W4309153886 cites W2281344836 @default.
- W4309153886 cites W2290820108 @default.
- W4309153886 cites W2308368972 @default.
- W4309153886 cites W2346480860 @default.
- W4309153886 cites W2409907752 @default.
- W4309153886 cites W2503932051 @default.
- W4309153886 cites W2509738156 @default.
- W4309153886 cites W2511152819 @default.
- W4309153886 cites W2518166184 @default.
- W4309153886 cites W2530008209 @default.
- W4309153886 cites W2549172728 @default.
- W4309153886 cites W2572160591 @default.
- W4309153886 cites W2574939094 @default.
- W4309153886 cites W2596178227 @default.
- W4309153886 cites W2598176747 @default.
- W4309153886 cites W2606895029 @default.
- W4309153886 cites W2612061536 @default.
- W4309153886 cites W2613653038 @default.
- W4309153886 cites W2624872288 @default.
- W4309153886 cites W2735227331 @default.
- W4309153886 cites W2742090168 @default.
- W4309153886 cites W2754041968 @default.
- W4309153886 cites W2767378207 @default.
- W4309153886 cites W2783029521 @default.
- W4309153886 cites W2792347611 @default.
- W4309153886 cites W2792805849 @default.
- W4309153886 cites W2799410199 @default.
- W4309153886 cites W2799487719 @default.
- W4309153886 cites W2801595185 @default.
- W4309153886 cites W2888994119 @default.
- W4309153886 cites W2891534479 @default.
- W4309153886 cites W2897342629 @default.
- W4309153886 cites W2903434859 @default.
- W4309153886 cites W2906592796 @default.
- W4309153886 cites W2921096313 @default.
- W4309153886 cites W2922165799 @default.
- W4309153886 cites W2926044118 @default.
- W4309153886 cites W2927736677 @default.
- W4309153886 cites W2945525372 @default.
- W4309153886 cites W2949661550 @default.
- W4309153886 cites W2950463913 @default.
- W4309153886 cites W2951748044 @default.
- W4309153886 cites W2952235410 @default.
- W4309153886 cites W2952776850 @default.
- W4309153886 cites W2956625763 @default.
- W4309153886 cites W2965614518 @default.
- W4309153886 cites W2967458208 @default.
- W4309153886 cites W2974612830 @default.
- W4309153886 cites W2976391042 @default.
- W4309153886 cites W2986421215 @default.
- W4309153886 cites W2993174708 @default.
- W4309153886 cites W3000222929 @default.
- W4309153886 cites W3000498477 @default.
- W4309153886 cites W3013536544 @default.
- W4309153886 cites W3014947672 @default.
- W4309153886 cites W3016565860 @default.
- W4309153886 cites W3020855961 @default.