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- W4309162203 abstract "Podoplanin (PDPN) is a small transmembrane mucin-like glycoprotein which is expressed on the surface of lymphatic endothelial cells, glomerular podocytes, type-I alveolar epithelial cells and some tumor cells. PDPN plays crucial function in variety of physiological and pathological processes such as embryonic development, immunoreaction, inflammation and cancer. C-type lectin-like receptor 2 (CLEC2) is mainly expressed on the platelet which specific ligand is PDPN. The interaction between PDPN and CLEC2 has received extensive attention. In this review, we summarized recent researches on the role of in sepsis and elaborated the possible mechanisms and some potential therapies for sepsis by targeting PDPN, which may provide theoretical basis for the mechanism and treatment of sepsis." @default.
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- W4309162203 date "2022-09-01" @default.
- W4309162203 modified "2023-09-30" @default.
- W4309162203 title "[Research progress on the mechanism of role of podoplanin in sepsis]." @default.
- W4309162203 doi "https://doi.org/10.3760/cma.j.cn121430-20211012-01473" @default.
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