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- W4309164812 abstract "Abstract: Immunotherapy has completely changed the treatment pattern of lung cancer and significantly prolonged the overall survival of patients, especially for advanced patients. However, a large number of lung cancer patients are unable to benefit from immunotherapy, which forces us to find new therapeutic targets to overcome drug resistance to immunotherapy. Cyclical GMP-AMP synthetase (cGAS) recognizes cytoplasmic DNA and promotes the formation of cyclical GMP-AMP (cGAMP), activates stimulator of interferon genes (STING), then induces the expression of varieties pro-inflammatory cytokines and chemokines, and then promotes the cross-presentation of dendritic cells (DCs) and initiates tumor-specific CD8+T cell response, showing great potential to overcome resistance and enhance antitumor immunity. In this review，we describe recent advances in the biological function，activation mode， and current applications of cGAS-STING pathway in lung cancer therapy. We also describe the mechanisms of the inactivation of cGAS-STING pathway in lung cancer cells， hoping to promote the progress of immunotherapy of lung cancer by targeting cGAS-STING pathway." @default.
- W4309164812 created "2022-11-24" @default.
- W4309164812 creator A5036291938 @default.
- W4309164812 creator A5049692788 @default.
- W4309164812 creator A5070332709 @default.
- W4309164812 date "2023-05-01" @default.
- W4309164812 modified "2023-09-30" @default.
- W4309164812 title "cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer" @default.
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- W4309164812 doi "https://doi.org/10.2174/1568009623666221115095114" @default.
- W4309164812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36380440" @default.
- W4309164812 hasPublicationYear "2023" @default.
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