FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309165639> ?p ?o ?g. }

• W4309165639 abstract "Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS-targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are identified by screening. OXPHOS inhibition-sensitive cancer cells possess increased OXPHOS activity and silenced nicotinamide N-methyltransferase (NNMT) expression. NNMT expression negatively correlates with OXPHOS inhibition sensitivity and functionally downregulates the intracellular levels of S-adenosyl methionine (SAM). Expression of DNA methyltransferase 1 (DNMT1), a SAM consumer, positively correlates with OXPHOS inhibition sensitivity. NNMT overexpression and DNMT1 inhibition render OXPHOS inhibition-sensitive cancer cells resistant. Importantly, treatments of OXPHOS inhibitors (Gboxin and Berberine) hamper the growth of mouse tumor xenografts by OXPHOS inhibition sensitive but not resistant cancer cells. What's more, the retrospective study of 62 tumor samples from a clinical trial demonstrates that administration of Berberine reduces the tumor recurrence rate of NNMTlow /DNMT1high but not NNMThigh /DNMT1low colorectal adenomas (CRAs). These results thus reveal a critical role of the NNMT-DNMT1 axis in determining cancer cell reliance on mitochondrial OXPHOS and suggest that NNMT and DNMT1 are faithful biomarkers for OXPHOS-targeting cancer therapies." @default.
• W4309165639 created "2022-11-24" @default.
• W4309165639 creator A5000977982 @default.
• W4309165639 creator A5005381760 @default.
• W4309165639 creator A5005496208 @default.
• W4309165639 creator A5010479652 @default.
• W4309165639 creator A5013308419 @default.
• W4309165639 creator A5013736647 @default.
• W4309165639 creator A5020445531 @default.
• W4309165639 creator A5033729673 @default.
• W4309165639 creator A5039635290 @default.
• W4309165639 creator A5042323521 @default.
• W4309165639 creator A5051965484 @default.
• W4309165639 creator A5052864536 @default.
• W4309165639 creator A5054857538 @default.
• W4309165639 creator A5057537114 @default.
• W4309165639 creator A5064189236 @default.
• W4309165639 creator A5067071158 @default.
• W4309165639 creator A5072109131 @default.
• W4309165639 creator A5083674053 @default.
• W4309165639 date "2022-11-16" @default.
• W4309165639 modified "2023-10-17" @default.
• W4309165639 title "NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition" @default.
• W4309165639 cites W1519629411 @default.
• W4309165639 cites W1524437146 @default.
• W4309165639 cites W1550090658 @default.
• W4309165639 cites W169918989 @default.
• W4309165639 cites W1884906615 @default.
• W4309165639 cites W2006640374 @default.
• W4309165639 cites W2010179451 @default.
• W4309165639 cites W2014742651 @default.
• W4309165639 cites W2026198465 @default.
• W4309165639 cites W2032917789 @default.
• W4309165639 cites W2035010201 @default.
• W4309165639 cites W2037087042 @default.
• W4309165639 cites W2074572949 @default.
• W4309165639 cites W2093896423 @default.
• W4309165639 cites W2101045506 @default.
• W4309165639 cites W2114599216 @default.
• W4309165639 cites W2127829299 @default.
• W4309165639 cites W2129092167 @default.
• W4309165639 cites W2136905998 @default.
• W4309165639 cites W2142745453 @default.
• W4309165639 cites W2152656267 @default.
• W4309165639 cites W2156519214 @default.
• W4309165639 cites W2167319166 @default.
• W4309165639 cites W2174991333 @default.
• W4309165639 cites W2234115940 @default.
• W4309165639 cites W2465370157 @default.
• W4309165639 cites W2513105811 @default.
• W4309165639 cites W2607083489 @default.
• W4309165639 cites W2618870156 @default.
• W4309165639 cites W2758067903 @default.
• W4309165639 cites W2766704091 @default.
• W4309165639 cites W2791235391 @default.
• W4309165639 cites W2809675891 @default.
• W4309165639 cites W2909369603 @default.
• W4309165639 cites W2920394342 @default.
• W4309165639 cites W2942537534 @default.
• W4309165639 cites W2943984860 @default.
• W4309165639 cites W2968658941 @default.
• W4309165639 cites W2969222685 @default.
• W4309165639 cites W2972170432 @default.
• W4309165639 cites W2999960074 @default.
• W4309165639 cites W3010323140 @default.
• W4309165639 cites W3036426980 @default.
• W4309165639 cites W3041473917 @default.
• W4309165639 cites W3092457640 @default.
• W4309165639 cites W3101436145 @default.
• W4309165639 cites W3130039072 @default.
• W4309165639 cites W3165482261 @default.
• W4309165639 cites W3179084948 @default.
• W4309165639 cites W4309165639 @default.
• W4309165639 doi "https://doi.org/10.1002/advs.202202642" @default.
• W4309165639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36382559" @default.
• W4309165639 hasPublicationYear "2022" @default.
• W4309165639 type Work @default.
• W4309165639 citedByCount "6" @default.
• W4309165639 countsByYear W43091656392022 @default.
• W4309165639 countsByYear W43091656392023 @default.
• W4309165639 crossrefType "journal-article" @default.
• W4309165639 hasAuthorship W4309165639A5000977982 @default.
• W4309165639 hasAuthorship W4309165639A5005381760 @default.
• W4309165639 hasAuthorship W4309165639A5005496208 @default.
• W4309165639 hasAuthorship W4309165639A5010479652 @default.
• W4309165639 hasAuthorship W4309165639A5013308419 @default.
• W4309165639 hasAuthorship W4309165639A5013736647 @default.
• W4309165639 hasAuthorship W4309165639A5020445531 @default.
• W4309165639 hasAuthorship W4309165639A5033729673 @default.
• W4309165639 hasAuthorship W4309165639A5039635290 @default.
• W4309165639 hasAuthorship W4309165639A5042323521 @default.
• W4309165639 hasAuthorship W4309165639A5051965484 @default.
• W4309165639 hasAuthorship W4309165639A5052864536 @default.
• W4309165639 hasAuthorship W4309165639A5054857538 @default.
• W4309165639 hasAuthorship W4309165639A5057537114 @default.
• W4309165639 hasAuthorship W4309165639A5064189236 @default.
• W4309165639 hasAuthorship W4309165639A5067071158 @default.
• W4309165639 hasAuthorship W4309165639A5072109131 @default.
• W4309165639 hasAuthorship W4309165639A5083674053 @default.
• W4309165639 hasBestOaLocation W43091656391 @default.

• next