Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309176962> ?p ?o ?g. }
- W4309176962 abstract "Abstract Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amplification also exists; rather, they have a deleted region at chromosome arm 11q. Twenty-six miRNAs are located within the breakpoint region of chromosome 11q and have been checked for a possible involvement in development of neuroblastoma due to the genomic alteration. Target genes of these miRNAs are involved in pathways associated with cancer, including proliferation, apoptosis and DNA repair. We could show that miR-548l found within the 11q region is downregulated in neuroblastoma cell lines with 11q deletion or MYCN amplification. In addition, we showed that the restoration of miR-548l level in a neuroblastoma cell line led to a decreased proliferation of these cells as well as a decrease in the percentage of cells in the S phase. We also found that miR-548l overexpression suppressed cell viability and promoted apoptosis, while miR-548l knockdown promoted cell viability and inhibited apoptosis in neuroblastoma cells. Our results indicate that 11q-deleted neuroblastoma and MYCN amplified neuroblastoma coalesce by downregulating miR-548l." @default.
- W4309176962 created "2022-11-24" @default.
- W4309176962 creator A5027536269 @default.
- W4309176962 creator A5038083124 @default.
- W4309176962 creator A5059264497 @default.
- W4309176962 creator A5067000653 @default.
- W4309176962 creator A5074530744 @default.
- W4309176962 date "2022-11-17" @default.
- W4309176962 modified "2023-10-14" @default.
- W4309176962 title "Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells" @default.
- W4309176962 cites W144423133 @default.
- W4309176962 cites W1547168939 @default.
- W4309176962 cites W1595017365 @default.
- W4309176962 cites W1965948654 @default.
- W4309176962 cites W1974456225 @default.
- W4309176962 cites W1986522151 @default.
- W4309176962 cites W1992294689 @default.
- W4309176962 cites W1992890836 @default.
- W4309176962 cites W1992941735 @default.
- W4309176962 cites W2017199818 @default.
- W4309176962 cites W2026570544 @default.
- W4309176962 cites W2046623154 @default.
- W4309176962 cites W2079479637 @default.
- W4309176962 cites W2083381199 @default.
- W4309176962 cites W2085865585 @default.
- W4309176962 cites W2090090573 @default.
- W4309176962 cites W2092310019 @default.
- W4309176962 cites W2097055142 @default.
- W4309176962 cites W2103912979 @default.
- W4309176962 cites W2107277218 @default.
- W4309176962 cites W2112413714 @default.
- W4309176962 cites W2130979840 @default.
- W4309176962 cites W2132546867 @default.
- W4309176962 cites W2152026276 @default.
- W4309176962 cites W2152420890 @default.
- W4309176962 cites W2158010566 @default.
- W4309176962 cites W2159482845 @default.
- W4309176962 cites W2165801731 @default.
- W4309176962 cites W2167557255 @default.
- W4309176962 cites W2171398108 @default.
- W4309176962 cites W2192080449 @default.
- W4309176962 cites W2300230725 @default.
- W4309176962 cites W2534856436 @default.
- W4309176962 cites W2602561919 @default.
- W4309176962 cites W2606897931 @default.
- W4309176962 cites W2729833834 @default.
- W4309176962 cites W2736520162 @default.
- W4309176962 cites W2747877968 @default.
- W4309176962 cites W2771288493 @default.
- W4309176962 cites W2788562722 @default.
- W4309176962 cites W2795690442 @default.
- W4309176962 cites W2914525890 @default.
- W4309176962 cites W2915052615 @default.
- W4309176962 cites W2922046826 @default.
- W4309176962 cites W2944545583 @default.
- W4309176962 cites W2995379304 @default.
- W4309176962 cites W3009578565 @default.
- W4309176962 cites W3015444296 @default.
- W4309176962 cites W3015918863 @default.
- W4309176962 cites W3016712194 @default.
- W4309176962 cites W3089119463 @default.
- W4309176962 cites W3127223990 @default.
- W4309176962 cites W3158639418 @default.
- W4309176962 cites W4294216483 @default.
- W4309176962 cites W2769816719 @default.
- W4309176962 doi "https://doi.org/10.1038/s41598-022-24140-6" @default.
- W4309176962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36396668" @default.
- W4309176962 hasPublicationYear "2022" @default.
- W4309176962 type Work @default.
- W4309176962 citedByCount "0" @default.
- W4309176962 crossrefType "journal-article" @default.
- W4309176962 hasAuthorship W4309176962A5027536269 @default.
- W4309176962 hasAuthorship W4309176962A5038083124 @default.
- W4309176962 hasAuthorship W4309176962A5059264497 @default.
- W4309176962 hasAuthorship W4309176962A5067000653 @default.
- W4309176962 hasAuthorship W4309176962A5074530744 @default.
- W4309176962 hasBestOaLocation W43091769621 @default.
- W4309176962 hasConcept C104317684 @default.
- W4309176962 hasConcept C121608353 @default.
- W4309176962 hasConcept C145059251 @default.
- W4309176962 hasConcept C153911025 @default.
- W4309176962 hasConcept C173396325 @default.
- W4309176962 hasConcept C190283241 @default.
- W4309176962 hasConcept C206936463 @default.
- W4309176962 hasConcept C2776715637 @default.
- W4309176962 hasConcept C2781018059 @default.
- W4309176962 hasConcept C29537977 @default.
- W4309176962 hasConcept C2993561819 @default.
- W4309176962 hasConcept C30481170 @default.
- W4309176962 hasConcept C502942594 @default.
- W4309176962 hasConcept C54355233 @default.
- W4309176962 hasConcept C81885089 @default.
- W4309176962 hasConcept C86803240 @default.
- W4309176962 hasConceptScore W4309176962C104317684 @default.
- W4309176962 hasConceptScore W4309176962C121608353 @default.
- W4309176962 hasConceptScore W4309176962C145059251 @default.
- W4309176962 hasConceptScore W4309176962C153911025 @default.
- W4309176962 hasConceptScore W4309176962C173396325 @default.
- W4309176962 hasConceptScore W4309176962C190283241 @default.
- W4309176962 hasConceptScore W4309176962C206936463 @default.