Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309179911> ?p ?o ?g. }
- W4309179911 endingPage "100917" @default.
- W4309179911 startingPage "100917" @default.
- W4309179911 abstract "Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover occurring in cancer cell proliferation. Though the role of folate as a causative versus protective agent in carcinogenesis is debated, several studies have indicated that the folate receptor (FR), notably subtype folate receptor alpha (FRα), could be a viable biomarker for diagnosis, progression, and prognosis. Several cancers, including gastrointestinal, gynecological, breast, lung, and squamous cell head and neck cancers overexpress FR and are currently under investigation to correlate receptor status to disease state. Traditional chemotherapies have included antifolate medications, such as methotrexate and pemetrexed, which generate anticancer activity during the synthesis phase of the cell cycle. Increasingly, the repertoire of pharmacotherapies is expanding to include FR as a target, with a heterogenous pool of directed therapies. Here we discuss the FR, expression and effect in cancer biology, and relevant pharmacologic inhibitors." @default.
- W4309179911 created "2022-11-24" @default.
- W4309179911 creator A5001476345 @default.
- W4309179911 creator A5023252433 @default.
- W4309179911 creator A5028977789 @default.
- W4309179911 creator A5053308469 @default.
- W4309179911 creator A5055054082 @default.
- W4309179911 creator A5064537232 @default.
- W4309179911 creator A5073965907 @default.
- W4309179911 date "2023-02-01" @default.
- W4309179911 modified "2023-10-01" @default.
- W4309179911 title "Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors" @default.
- W4309179911 cites W1011507567 @default.
- W4309179911 cites W112828355 @default.
- W4309179911 cites W12421426 @default.
- W4309179911 cites W1278072151 @default.
- W4309179911 cites W1955295242 @default.
- W4309179911 cites W1965256036 @default.
- W4309179911 cites W1965931924 @default.
- W4309179911 cites W1968051127 @default.
- W4309179911 cites W1969825132 @default.
- W4309179911 cites W1970829695 @default.
- W4309179911 cites W1971804824 @default.
- W4309179911 cites W1971894436 @default.
- W4309179911 cites W1972849029 @default.
- W4309179911 cites W1973108158 @default.
- W4309179911 cites W1974943840 @default.
- W4309179911 cites W1976971356 @default.
- W4309179911 cites W1978514556 @default.
- W4309179911 cites W1981271620 @default.
- W4309179911 cites W1981491101 @default.
- W4309179911 cites W1984328540 @default.
- W4309179911 cites W1985072203 @default.
- W4309179911 cites W1993231275 @default.
- W4309179911 cites W1998290168 @default.
- W4309179911 cites W2000858463 @default.
- W4309179911 cites W2000924275 @default.
- W4309179911 cites W2001119796 @default.
- W4309179911 cites W2005564022 @default.
- W4309179911 cites W2008807793 @default.
- W4309179911 cites W2009193838 @default.
- W4309179911 cites W2010868528 @default.
- W4309179911 cites W2013891780 @default.
- W4309179911 cites W2021432766 @default.
- W4309179911 cites W2024132257 @default.
- W4309179911 cites W2024856950 @default.
- W4309179911 cites W2025772696 @default.
- W4309179911 cites W2026865847 @default.
- W4309179911 cites W2027689392 @default.
- W4309179911 cites W2028776386 @default.
- W4309179911 cites W2038925947 @default.
- W4309179911 cites W2041110763 @default.
- W4309179911 cites W2042118791 @default.
- W4309179911 cites W2042493999 @default.
- W4309179911 cites W2043179683 @default.
- W4309179911 cites W2047574209 @default.
- W4309179911 cites W2049490668 @default.
- W4309179911 cites W2051052717 @default.
- W4309179911 cites W2051980540 @default.
- W4309179911 cites W2052078667 @default.
- W4309179911 cites W2053558130 @default.
- W4309179911 cites W2056450557 @default.
- W4309179911 cites W2060459188 @default.
- W4309179911 cites W2060882819 @default.
- W4309179911 cites W2064834559 @default.
- W4309179911 cites W2074544404 @default.
- W4309179911 cites W2076222693 @default.
- W4309179911 cites W2076541469 @default.
- W4309179911 cites W2077250280 @default.
- W4309179911 cites W2079082252 @default.
- W4309179911 cites W2083035675 @default.
- W4309179911 cites W2087675944 @default.
- W4309179911 cites W2092334961 @default.
- W4309179911 cites W2092721125 @default.
- W4309179911 cites W2097007428 @default.
- W4309179911 cites W2099725888 @default.
- W4309179911 cites W2101259585 @default.
- W4309179911 cites W2104182248 @default.
- W4309179911 cites W2109621565 @default.
- W4309179911 cites W2114230622 @default.
- W4309179911 cites W2122092859 @default.
- W4309179911 cites W2126864090 @default.
- W4309179911 cites W2133374918 @default.
- W4309179911 cites W2133786616 @default.
- W4309179911 cites W2138926750 @default.
- W4309179911 cites W2139761471 @default.
- W4309179911 cites W2140626944 @default.
- W4309179911 cites W2140853963 @default.
- W4309179911 cites W2148367564 @default.
- W4309179911 cites W2154669605 @default.
- W4309179911 cites W2156806290 @default.
- W4309179911 cites W2157203835 @default.
- W4309179911 cites W2159003771 @default.
- W4309179911 cites W2159905203 @default.
- W4309179911 cites W2167077543 @default.
- W4309179911 cites W2170664203 @default.
- W4309179911 cites W2179141110 @default.
- W4309179911 cites W2270628532 @default.